Results 21 to 30 of about 38,575 (293)

Furin is the major proprotein convertase required for KISS1-to-Kisspeptin processing. [PDF]

PLoS ONE, 2014
KISS1 is a broadly functional secreted proprotein that is then processed into small peptides, termed kisspeptins (KP). Since sequence analysis showed cleavage at KR or RR dibasic sites of the nascent protein, it was hypothesized that enzyme(s) belonging ...
Sitaram Harihar, Keke M Pounds, Tomoo Iwakuma, Nabil G Seidah, Danny R Welch   +4 more
doaj   +1 more source

Furin Regulates the Alveolarization of Neonatal Lungs in a Mouse Model of Hyperoxic Lung Injury

Biomolecules, 2023
Despite advances in treatment options, such as corticosteroid administration and less invasive respiratory support, bronchopulmonary dysplasia (BPD) remains an important prognostic factor in preterm infants.
Shin Kato, Osuke Iwata, Hiroyuki Kato, Satoko Fukaya, Yukari Imai, Shinji Saitoh   +5 more
doaj   +1 more source

Cationic Cell-Penetrating Peptides Are Potent Furin Inhibitors. [PDF]

PLoS ONE, 2015
Cationic cell-penetrating peptides have been widely used to enhance the intracellular delivery of various types of cargoes, such as drugs and proteins.
Bruno Ramos-Molina, Adam N Lick, Amir Nasrolahi Shirazi, Donghoon Oh, Rakesh Tiwari, Naglaa Salem El-Sayed, Keykavous Parang, Iris Lindberg   +7 more
doaj   +1 more source

New Insight Into Metformin-Induced Cholesterol-Lowering Effect Crosstalk Between Glucose and Cholesterol Homeostasis via ChREBP (Carbohydrate-Responsive Element-Binding Protein)-Mediated PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Regulation.

Arteriosclerosis, Thrombosis and Vascular Biology, 2021
OBJECTIVE Metformin, a first-line drug for treating individuals with type 2 diabetes, exerts beneficial effects on cholesterol-lowering, yet its precise mechanism has not been established.
Die Hu, Yanhong Guo, R. Wu, Tiannan Shao, Junke Long, Bilian Yu, Huilun Wang, Yonghong Luo, Haocheng Lu, Jifeng Zhang, Y. E. Chen, Daoquan Peng   +11 more
semanticscholar   +1 more source

Proprotein Convertase Subtilisin Kexin Type 9 Inhibitors Reduce Platelet Activation Modulating ox-LDL Pathways

International Journal of Molecular Sciences, 2021
Background: Proprotein convertase subtilisin kexin type 9 inhibitors (PCSK9i) lower LDL-cholesterol and slow atherosclerosis preventing cardiovascular events.
V. Cammisotto, F. Baratta, Valentina Castellani, S. Bartimoccia, C. Nocella, L. D’Erasmo, N. Cocomello, C. Barale, Roberto Scicali, A. Di Pino, S. Piro, M. del Ben, M. Arca, I. Russo, F. Purrello, R. Carnevale, F. Violi, D. Pastori, P. Pignatelli   +18 more
semanticscholar   +1 more source

Hysteretic behavior of proprotein convertase 1/3 (PC1/3). [PDF]

PLoS ONE, 2011
The proprotein convertases (PCs) are calcium-dependent proteases responsible for processing precursor proteins into their active forms in eukariotes.
Marcelo Y Icimoto, Nilana M Barros, Juliana C Ferreira, Marcelo F Marcondes, Douglas Andrade, Mauricio F Machado, Maria A Juliano, Wagner A Júdice, Luiz Juliano, Vitor Oliveira   +9 more
doaj   +1 more source

Sex difference in circulating PCSK9 and its clinical implications

Frontiers in Pharmacology, 2022
Proprotein convertase subtilisin kexin type 9 (PCSK9) is a proprotein convertase that increases plasma low-density lipoprotein cholesterol (LDL-C) levels by triggering the degradation of LDL receptors (LDLRs).
Fang Jia, Si-Fan Fei, De-Bing Tong, Cong Xue, Jian-Jun Li   +4 more
doaj   +1 more source

Proprotein Convertase Is the Highest-Level Activator of the Alternative Complement Pathway in the Blood

Journal of Immunology, 2021
Key Points MASP-3 circulates mainly as an active enzyme and activates pro–factor D. MASP-3 is activated by the proprotein convertase, PCSK6, in the blood. Our discovery links the complement and the proprotein convertase systems. Visual Abstract Factor D (
G. Oroszlán, Ráhel Dani, B. Végh, Dóra Varga, A. Acs, G. Pál, P. Závodszky, H. Farkas, P. Gál, J. Dobó   +9 more
semanticscholar   +1 more source

OFF-State-Specific Inhibition of the Proprotein Convertase Furin

ACS Chemical Biology, 2021
The pro-protein convertase furin is a highly specific serine protease involved in the proteolytic maturation of many proteins in the secretory pathway.
S. O. Dahms, Tanja Haider, G. Klebe, T. Steinmetzer, H. Brandstetter   +4 more
semanticscholar   +1 more source

Stroke Prevention With the PCSK9 (Proprotein Convertase Subtilisin-Kexin Type 9) Inhibitor Evolocumab Added to Statin in High-Risk Patients With Stable Atherosclerosis

Stroke, 2020
Supplemental Digital Content is available in the text. Background and Purpose— The PCSK9 (proprotein convertase subtilisin-kexin type 9) monoclonal antibody evolocumab lowered LDL (low-density lipoprotein) cholesterol by 59% to 0.8 (0.5–1.2) mmol/L and ...
R. Giugliano, T. Pedersen, J. Saver, P. Sever, A. Keech, E. Bohula, S. Murphy, S. Wasserman, Narimon Honarpour, Hong Wang, Armando Lira Pineda, M. Sabatine   +11 more
semanticscholar   +1 more source