The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions. [PDF]
J Biol Chem, 2013 The secretory proprotein convertase (PC) family comprises nine members: PC1/3, PC2, furin, PC4, PC5/6, PACE4, PC7, SKI-1/S1P, and PCSK9. The first seven PCs cleave their substrates at single or paired basic residues, and SKI-1/S1P cleaves its substrates ...
Seidah NG +3 more
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Mechanism of Fine-tuning pH Sensors in Proprotein Convertases: IDENTIFICATION OF A pH-SENSING HISTIDINE PAIR IN THE PROPEPTIDE OF PROPROTEIN CONVERTASE 1/3. [PDF]
J Biol Chem, 2015 Background: Propeptides regulate the organelle-specific, pH-dependent activation of proprotein convertases. Results: A histidine residue pair in the propeptide cooperatively defines the activation pH for proprotein convertase 1/3.
Williamson DM, Elferich J, Shinde U.
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Relative expression of proprotein convertases in rat ovaries during pregnancy. [PDF]
J Ovarian Res, 2013 BackgroundProprotein convertases are a family of serine proteinases that are related to bacterial subtilisin and yeast kexin. They are involved in posttranslational processing of the precursors of a vast number of cellular proteins. With the exception of
Kwok SC +3 more
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Hysteretic behavior of proprotein convertase 1/3 (PC1/3). [PDF]
PLoS ONE, 2011 The proprotein convertases (PCs) are calcium-dependent proteases responsible for processing precursor proteins into their active forms in eukariotes.
Marcelo Y Icimoto +9 more
doaj +6 more sources
The proprotein convertase furin in tumour progression [PDF]
International Journal of Cancer, 2017 Proprotein convertases are proteases that have been implicated in the activation of a wide variety of proteins. These proteins are generally synthesised as precursor proteins and require limited proteolysis for conversion into their mature bioactive counterparts.
Michele Bernasconi
exaly +5 more sources
Inhibition of proprotein convertases abrogates processing of the middle eastern respiratory syndrome coronavirus spike protein in infected cells but does not reduce viral infectivity. [PDF]
J Infect Dis, 2015 Middle East respiratory syndrome coronavirus (MERS-CoV) infection is associated with a high case-fatality rate, and the potential pandemic spread of the virus is a public health concern. The spike protein of MERS-CoV (MERS-S) facilitates viral entry into
Gierer S +9 more
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Repression of liver colorectal metastasis by the serpin Spn4A a naturally occurring inhibitor of the constitutive secretory proprotein convertases. [PDF]
Oncotarget, 2014 Liver is the most common site of metastasis from colorectal cancers, and liver of patients with liver colorectal metastasis have abnormal levels of the proprotein convertases (PCs).
Sfaxi F +9 more
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Implications of Proprotein Convertases in Ovarian Cancer Cell Proliferation and Tumor Progression: Insights for PACE4 as a Therapeutic Target. [PDF]
Transl Oncol, 2014 Proprotein convertases are a family of kexin-like serine proteases that process proteins at single and multiple basic residues. Among the predicted and identified PC substrates, an increasing number of proteins having functions in cancer progression ...
Longuespée R +10 more
europepmc +3 more sources
Prediction of proprotein convertase cleavage sites [PDF]
Protein Engineering, Design and Selection, 2004 Many secretory proteins and peptides are synthesized as inactive precursors that in addition to signal peptide cleavage undergo post-translational processing to become biologically active polypeptides. Precursors are usually cleaved at sites composed of single or paired basic amino acid residues by members of the subtilisin/kexin-like proprotein ...
Peter Duckert +2 more
openalex +4 more sources
Proprotein convertases: Key players in inflammation-related malignancies and metastasis. [PDF]
Cancer Lett, 2020 Siegfried G +3 more
europepmc +2 more sources