Results 51 to 60 of about 5,923 (228)

Therapeutic potential of the Proprotein Convertase Subtilisin/Kexin family in vascular disease

Frontiers in Pharmacology, 2022
Proprotein convertase subtilisin/kexins (PCSKs) constitute a family of nine related proteases: PCSK1-7, MBTPS1, and PCSK9. Apart from PCSK9, little is known about PCSKs in cardiovascular disease. Here, we aimed to investigate the expression landscape and
Bianca E. Suur, Melody Chemaly, Moritz Lindquist Liljeqvist, Djordje Djordjevic, Djordje Djordjevic, Markus Stenemo, Otto Bergman, Eva Karlöf, Mariette Lengquist, Jacob Odeberg, Jacob Odeberg, Eva Hurt-Camejo, Eva Hurt-Camejo, Per Eriksson, Daniel F.J. Ketelhuth, Daniel F.J. Ketelhuth, Joy Roy, Ulf Hedin, Michael Nyberg, Ljubica Matic   +19 more
doaj   +1 more source

Urinary peptidomics analysis reveals proteases involved in diabetic nephropathy [PDF]

, 2017
Mechanisms underlying the onset and progression of nephropathy in diabetic patients are not fully elucidated. Deregulation of proteolytic systems is a known path leading to disease manifestation, therefore we hypothesized that proteases aberrantly ...
Bascands, Jean-Loup, Delles, Christian, Denis, Colette, Husi, Holger, Klein, Julie, Kontostathi, Georgia, Krochmal, Magdalena, Leierer, Johannes, Magalhães, Pedro, Makridakis, Manousos, Mayer, Gert, Mischak, Harald, Schanstra, Joost P., Vlahou, Antonia, Zoidakis, Jerome, Zürbig, Petra   +15 more
core   +2 more sources

Brain-derived neurotrophic factor in megakaryocytes [PDF]

, 2016
The biosynthesis of endogenous BDNF has thus far been examined in neurons where it is expressed at very low levels, in an activity-dependent fashion. In humans, BDNF has long been known to accumulate in circulating platelets, at levels far higher than in
Barde, Yves-Alain, Chacon-Fernandez, Pedro, Colzani, Maria, Ghevaert, Cedric, Moreau, Thomas, Sauberli, Katharina   +5 more
core   +1 more source

A Molecular Sensor To Characterize Arenavirus Envelope Glycoprotein Cleavage by Subtilisin Kexin Isozyme 1/Site 1 Protease. [PDF]

, 2016
UNLABELLED: Arenaviruses are emerging viruses including several causative agents of severe hemorrhagic fevers in humans. The advent of next-generation sequencing technology has greatly accelerated the discovery of novel arenavirus species.
Bergeron, E., Burri, D.J., da Palma, J.R., Khatib, A.M., Kunz, S., Oppliger, J., Pasquato, A., Spiropoulou, C.F.   +7 more
core   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Compartment-Specific Biosensors Reveal a Complementary Subcellular Distribution of Bioactive Furin and PC7

Cell Reports, 2018
Summary: Furin trafficking, and that of related proprotein convertases (PCs), may regulate which substrates are accessible for endoproteolysis, but tools to directly test this hypothesis have been lacking.
Pierpaolo Ginefra, Bruno G.H. Filippi, Prudence Donovan, Sylvain Bessonnard, Daniel B. Constam   +4 more
doaj   +1 more source

Genome-wide and molecular evolution analysis of the subtilase gene family in [PDF]

, 2014
Background Vitis vinifera (grape) is one of the most economically significant fruit crops in the world. The availability of the recently released grape genome sequence offers an opportunity to identify and analyze some important gene families in this ...
Cao, Jun, Han, Xi, Hu, Xiangyang, Huang, Jinling, NC DOCKS at East Carolina University, Yang, Yongping, Zhang, Ticao   +6 more
core   +1 more source

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

How the Prohormone Theory Solved Two Important Controversies in Hormonal and Neural Peptide Biosynthesis

Frontiers in Endocrinology, 2013
This Prohormone Theory was simultaneously proposed in 1967 by two independent groups using two different approaches and two experimental models. Donald Steiner, in elegant pulse-chase experiments, proposed the existence of proinsulin when he observed ...
Michel eChretien
doaj   +1 more source

Inhaled Angiopoietin‐Like 4 Antisense Oligonucleotide Therapy for Lung Injury and Fibrosis

Advanced Science, EarlyView.
Inhaled antisense oligonucleotides targeting ANGPTL4 attenuate inflammation, preserve barrier integrity, and reduce fibrosis in both infectious and sterile lung injury models. Integrated transcriptomic analysis reveals a conserved ANGPTL4‐regulated gene network coordinating hypoxic, inflammatory, apoptotic, and stress‐response pathways.
Haiyang Fan, Yuanyang Tan, Junhang Zhang, Xiaoya Liu, Jing Qu, Damien Chua, Hong Sheng Cheng, Joseph Han Sol Kim, Yu Xuan Liu, Changfei Qin, Yingzi Liu, Dezhi Li, Jikang Qiu, Mengshi Chi, Mingmin Bi, Qiwei Zhang, Yun Li, Masoumeh Motamedi Joibari, Stefan K Nilsson, Nguan Soon Tan, Yunping Fan, Liang Li   +21 more
wiley   +1 more source