Extensive Basal Level Activation of Complement Mannose-Binding Lectin-Associated Serine Protease-3: Kinetic Modeling of Lectin Pathway Activation Provides Possible Mechanism [PDF]
, 2017 Serine proteases (SPs) are typically synthesized as precursors, termed proenzymes or zymogens, and the fully active form is produced via limited proteolysis by another protease or by autoactivation.
Dani, Ráhel +6 more
core +4 more sources
Urinary peptidomics analysis reveals proteases involved in diabetic nephropathy [PDF]
, 2017 Mechanisms underlying the onset and progression of nephropathy in diabetic patients are not fully elucidated. Deregulation of proteolytic systems is a known path leading to disease manifestation, therefore we hypothesized that proteases aberrantly ...
Bascands, Jean-Loup +15 more
core +2 more sources
Molecular evolution of PCSK family: Analysis of natural selection rate and gene loss.
PLoS ONE, 2021 Proprotein convertases subtilisin kexins are serine endoproteases, playing critical roles in the biological functions, including lipid, glucose, and bile acid metabolism, as well as cell proliferation, migration, and metastasis. Experimental studies have
Najmeh Parvaz, Zahra Jalali
doaj +2 more sources
Therapeutic potential of the Proprotein Convertase Subtilisin/Kexin family in vascular disease
Frontiers in Pharmacology, 2022 Proprotein convertase subtilisin/kexins (PCSKs) constitute a family of nine related proteases: PCSK1-7, MBTPS1, and PCSK9. Apart from PCSK9, little is known about PCSKs in cardiovascular disease. Here, we aimed to investigate the expression landscape and
Bianca E. Suur +19 more
doaj +1 more source
Genome-wide and molecular evolution analysis of the subtilase gene family in [PDF]
, 2014 Background Vitis vinifera (grape) is one of the most economically significant fruit crops in the world. The availability of the recently released grape genome sequence offers an opportunity to identify and analyze some important gene families in this ...
Cao, Jun +6 more
core +1 more source
A Molecular Sensor To Characterize Arenavirus Envelope Glycoprotein Cleavage by Subtilisin Kexin Isozyme 1/Site 1 Protease. [PDF]
, 2016 UNLABELLED: Arenaviruses are emerging viruses including several causative agents of severe hemorrhagic fevers in humans. The advent of next-generation sequencing technology has greatly accelerated the discovery of novel arenavirus species.
Bergeron, E. +7 more
core +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 859-868, April 2025.Abstract Aims Natriuretic peptide‐based pre‐heart failure screening has been proposed in recent guidelines. However, an effective strategy to identify screening targets from the general population, more than half of which are at risk for heart failure or pre‐heart failure, has not been well established.
Yuichiro Mori +5 more
wiley +1 more source
Brain-derived neurotrophic factor in megakaryocytes [PDF]
, 2016 The biosynthesis of endogenous BDNF has thus far been examined in neurons where it is expressed at very low levels, in an activity-dependent fashion. In humans, BDNF has long been known to accumulate in circulating platelets, at levels far higher than in
Barde, Yves-Alain +5 more
core +1 more source
Cell Reports, 2018 Summary: Furin trafficking, and that of related proprotein convertases (PCs), may regulate which substrates are accessible for endoproteolysis, but tools to directly test this hypothesis have been lacking.
Pierpaolo Ginefra +4 more
doaj +1 more source
The sequence flanking the N-terminus of the CLV3 peptide is critical for its cleavage and activity in stem cell regulation in Arabidopsis [PDF]
, 2013 The "Shakespeare Authorship Question"—regarding the identity of the poet-playwright—has been debated for over 150 years. Now, with the growing list of signatories to the "Declaration of Reasonable Doubt," the creation of a Master's Degree program in ...
Ting-Ting Xu +3 more
core +3 more sources