Results 61 to 70 of about 18,795 (277)

Convertases other than furin cleave β‐secretase to its mature form [PDF]

, 2001
An aspartyl protease, Beta‐Site APP cleaving enzyme (BACE), was identified as the β‐secretase responsible for generating the Amyloid β protein that is believed to cause Alzheimer’s disease.
Council, Jenny E., Mallender, William, Onstead, Luisa, Pinnix, Inga, Roseberry, Beverly, Sambamurti, Kumar, Sucic, Joseph   +6 more
core   +1 more source

A case‐study of model‐informed drug development of a novel PCSK9 anti sense oligonucleotide. Part 1: First time in man to phase II

CPT: Pharmacometrics &Systems Pharmacology, Volume 11, Issue 12, Page 1569-1577, December 2022., 2022
Abstract Here, we show model‐informed drug development (MIDD) of a novel antisense oligonucleotide, targeting PCSK9 for treatment of hypocholesteremia. The case study exemplifies use of MIDD to analyze emerging data from an ongoing first‐in‐human study, utility of the US Food and Drug Administration MIDD pilot program to accelerate timelines ...
Jane Knöchel, Catarina Nilsson, Björn Carlsson, Linda Wernevik, Alexis Hofherr, Peter Gennemark, Rasmus Jansson‐Löfmark, Rikard Isaksson, Tina Rydén‐Bergsten, Bengt Hamrén, Dinko Rekić   +10 more
wiley   +1 more source

Sphingomyelinases D From Loxosceles Spider Venoms and Cell Membranes: Action on Lipid Rafts and Activation of Endogenous Metalloproteinases

Frontiers in Pharmacology, 2020
Loxosceles spider venom contains Sphingomyelinase D (SMase D), the key toxin causing pathology. SMase D hydrolyzes the main component of lipid rafts, sphingomyelin, which changes the membrane microenvironment resulting in the activation of endogenous ...
Priscila Hess Lopes, Carmen W. van den Berg, Denise V. Tambourgi   +2 more
doaj   +1 more source

The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model [PDF]

, 2009
BACKGROUND: The secretory basic amino acid-specific proprotein convertases (PCs) have often been associated with cancer/metastasis. By controlling the cleavage of cancer-associated proteins, PCs play key roles in multiple steps of cancer development ...
Annik Prat, Annik Prat, Nabil G Seidah, Rachid Essalmani, Xiaowei Sun   +4 more
core   +3 more sources

Inactivation of proprotein convertases in T cells inhibits PD-1 expression and creates a favorable immune microenvironment in colorectal cancer.

Cancer Research, 2019
Proprotein convertases (PCs) activate precursor proteins that play crucial roles in various cancers. In this study, we investigated whether protein convertase enzyme activity is required for expression of the checkpoint protein programmed cell death ...
M. Tomé, A. Pappalardo, F. Soulet, J. López, J. Olaizola, Yannick Léger, Marielle Dubreuil, Amandine Mouchard, D. Fessart, F. Delom, V. Pitard, D. Béchade, M. Fonck, J. Rosado, F. Ghiringhelli, J. Déchanet-Merville, I. Soubeyran, G. Siegfried, S. Evrard, A. Khatib   +19 more
semanticscholar   +1 more source

Development of enhanced furin inhibitors with reduced toxicity as potential broad spectrum antiviral drugs [PDF]

, 2022
At the beginning of the twentieth century, the focus of peptide research was largely on human signalling hormones. A breakthrough in the field of peptide therapeutics was the first medicinal application of insulin isolated from animal pancreas, which ...
Lam van, Thuy Van
core   +1 more source

Markers of neutrophil mediated inflammation associate with disturbed continuous electroencephalogram after out of hospital cardiac arrest

Acta Anaesthesiologica Scandinavica, Volume 67, Issue 1, Page 94-103, January 2023., 2023
Abstract Background Achieving an acceptable neurological outcome in cardiac arrest survivors remains challenging. Ischemia‐reperfusion injury induces inflammation, which may cause secondary neurological damage. We studied the association of ICU admission levels of inflammatory biomarkers with disturbed 48‐hour continuous electroencephalogram (cEEG ...
Pirkka T. Pekkarinen, Federico Carbone, Silvia Minetti, Davide Ramoni, Giuseppe Ristagno, Roberto Latini, Lauri Wihersaari, Kaj Blennow, Henrik Zetterberg, Jussi Toppila, Pekka Jakkula, Matti Reinikainen, Fabrizio Montecucco, Markus B. Skrifvars   +13 more
wiley   +1 more source

The Dual α-Amidation System in Scorpion Venom Glands

Toxins, 2019
Many peptides in scorpion venoms are amidated at their C-termini. This post-translational modification is paramount for the correct biological function of ion channel toxins and antimicrobial peptides, among others.
Gustavo Delgado-Prudencio, Lourival D. Possani, Baltazar Becerril, Ernesto Ortiz   +3 more
doaj   +1 more source

Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst [PDF]

, 2010
The CLIP biosensor reveals the spatiotemporal activity of the Nodal proprotein convertases Furin and Pace4 during embryonic ...
Arnold, Beck, Ben-Haim, Blanchet, Brennan, Brennan, Cobos-Correa, Collignon, Constam, Constam, Constam, Constam, Constam, Coppola, Daniel B. Constam, Daniel Mesnard, Dragulescu-Andrasi, Essalmani, Feige, Fugère, Hadjantonakis, Hobson, Jares-Erijman, Jean, Jiao, Keller, Klimpel, Komiyama, Mayer, Mesnard, Minchiotti, Nour, Roebroek, Seidah, St Germain, Szumska, Takahashi, Thomas, Tsuji, van Rheenen, VanEngelenburg, Varlet, Yan, Yang   +43 more
core   +2 more sources

Inhibitory Feature of the Proprotein Convertases Prosegments

Medicinal Chemistry, 2008
The proprotein convertases (PCs) are serine proteases involved in various physiological processes and their overactivity or inactivity has been linked to different disorders. PCs are responsible for the proteolytic processing of various polypeptide precursors.
Bontemps, Yannick, Lapierre, Marion, Siegfried, Geraldine, Calvo, Fabien, Khatib, Abdel-Majid   +4 more
openaire   +5 more sources