Results 61 to 70 of about 5,923 (228)

The sequence flanking the N-terminus of the CLV3 peptide is critical for its cleavage and activity in stem cell regulation in Arabidopsis [PDF]

, 2013
The "Shakespeare Authorship Question"—regarding the identity of the poet-playwright—has been debated for over 150 years. Now, with the growing list of signatories to the "Declaration of Reasonable Doubt," the creation of a Master's Degree program in ...
Ting-Ting Xu, Xiu-Fen Song, Shi-Chao Ren, Chun-Ming Liu   +3 more
core   +3 more sources

Mouse Models of Human Proprotein Convertase Insufficiency

Endocrine Reviews, 2020
AbstractThe kexin-like proprotein convertases perform the initial proteolytic cleavages that ultimately generate a variety of different mature peptide and proteins, ranging from brain neuropeptides to endocrine peptide hormones, to structural proteins, among others.
Manita Shakya, Iris Lindberg
openaire   +3 more sources

The proprotein convertase furin in tumour progression [PDF]

International Journal of Cancer, 2017
Proprotein convertases are proteases that have been implicated in the activation of a wide variety of proteins. These proteins are generally synthesised as precursor proteins and require limited proteolysis for conversion into their mature bioactive counterparts.
Jaaks, Patricia, Bernasconi, Michele
openaire   +3 more sources

Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibition and Cancer Risk: Insights from a Large Propensity‐Matched Cohort Study

Clinical Pharmacology &Therapeutics, EarlyView.
Proprotein convertase subtilisin/kexin type 9 (PCSK9) monoclonal antibodies (mAbs) lower LDL cholesterol and may influence cancer through immunomodulatory pathways. However, their effect on human cancer incidence remains unknown. We conducted a retrospective, propensity score‐matched study (Clalit Health Services, Israel, 2010–2023) comparing PCSK9 ...
Inbar Nardi Agmon, Chen Gurevitz, Tzippy Shochat, Shiri Kushnir, Guy Witberg, Amos Levi, Dan Gilon, Ran Kornowski, Paaladinesh Thavendiranathan, Husam Abdel Qadir, Zaza Iakobishvili   +10 more
wiley   +1 more source

Biochemical characterization of proopiomelanocortin variants in human and owls [PDF]

, 2015
In humans the proopiomelanocortin (POMC) gene is located on the short arm of the chromosome 2 at the 23.3 position and encodes a 39kDa peptide with 241 amino acids. This peptide is the precursor of the proopiomelanocortin prohormone and it is produced in
SAINT-ROCH, A.
core  

Evaluation of genome-wide loci of iron metabolism in hereditary hemochromatosis identifies PCSK7 as a host risk factor of liver cirrhosis [PDF]

, 2016
Genome-wide association studies (GWAS) have revealed genetic determinants of iron metabolism, but correlation of these with clinical phenotypes is pending.
Aigner, Elmar, Arlt, Alexander, Becker, Thomas, Berg, Thomas, Boehm, Bernhard O., Braun, Felix, Buch, Stephan, D'Amato, Mauro, Datz, Christian, Dejaco, Christian, Erhart, Wiebke, Finkenstedt, Armin, Franke, Andre, Gallati, Sabina, Hampe, Jochen, Hinrichsen, Holger, Hultcrantz, Rolf, Kratzer, Wolfgang, Krawczak, Michael, Krones, Elisabeth, Lerch, Markus M., Mayerle, Julia, Nothnagel, Michael, Sahinbegovic, Enijad, Sarrazin, Christoph, Schafmayer, Clemens, Schaller, André, Sipos, Bence, Stadlmayr, Andreas, Stal, Per, Stickel, Felix, Strasser, Michael, Torkvist, Leif, Völzke, Henry, Zoller, Heinz, Zwerina, Jochen, Österreicher, Christoph   +36 more
core   +2 more sources

Proprotein convertase genes in Xenopus development [PDF]

Developmental Dynamics, 2005
AbstractProprotein convertases (PCs) are a family of serine endoproteases that proteolytically activate many precursor proteins within various secretory pathway compartments. Loss‐of‐function studies have demonstrated a critical role for these proteases in embryonic patterning and adult homeostasis, yet little is known about how substrate selectivity ...
Sylvia, Nelsen, Linnea, Berg, Crispin, Wong, Jan L, Christian   +3 more
openaire   +2 more sources

Machine learning‐based prediction of elevated N terminal pro brain natriuretic peptide among US general population

ESC Heart Failure, Volume 12, Issue 2, Page 859-868, April 2025.
Abstract Aims Natriuretic peptide‐based pre‐heart failure screening has been proposed in recent guidelines. However, an effective strategy to identify screening targets from the general population, more than half of which are at risk for heart failure or pre‐heart failure, has not been well established.
Yuichiro Mori, Shingo Fukuma, Kyohei Yamaji, Atsushi Mizuno, Naoki Kondo, Kosuke Inoue   +5 more
wiley   +1 more source

Comparative study of the binding pockets of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors

International Journal of Biological Sciences, 2010
Proprotein convertases are enzymes that proteolytically cleave protein precursors in the secretory pathway to yield functional proteins. Seven mammalian subtilisin/Kex2p-like proprotein convertases have been identified: furin, PC1, PC2, PC4, PACE4, PC5 ...
Sun Tian, Wu Jianhua
doaj  

Insights into the kinetics and dynamics of the furin-cleaved form of PCSK9

Journal of Lipid Research, 2021
Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates cholesterol metabolism by inducing the degradation of hepatic low density lipoprotein receptors (LDLRs). Plasma PCSK9 has 2 main molecular forms: a 62 kDa mature form (PCSK9_62) and a 55 kDa,
Carlota Oleaga, Joshua Hay, Emma Gurcan, Larry L. David, Paul A. Mueller, Hagai Tavori, Michael D. Shapiro, Nathalie Pamir, Sergio Fazio   +8 more
doaj   +1 more source