Results 81 to 90 of about 5,989 (280)

Reduced CB1 Cannabinoid Receptor Expression in Alzheimer's Disease and Transgenic Mouse Models

AGING MEDICINE, EarlyView.
CB1 receptor (CB1R) expression was significantly reduced in the hippocampus, medial frontal gyrus, and superior temporal gyrus of Alzheimer's patients. CB1R levels negatively correlated with amyloid‐β and tau pathology. In addition, CB1R expression was also reduced in the cortex of 5xFAD mice and in the hippocampus of Tg4‐42 mice.
Nike von Borcke, Amrei Vivian Purwien, Annik Steiert, Henrike Hasecke, Yvonne Bouter   +4 more
wiley   +1 more source

Composition‐Aware Cross‐Sectional Integration for Spatial Transcriptomics

Advanced Intelligent Discovery, EarlyView.
Multi‐section spatial transcriptomics demands coherent cell‐type deconvolution, domain detection, and batch correction, yet existing pipelines treat these tasks separately. FUSION unifies them within a composition‐aware latent framework, modeling reads as cell‐type–specific topics and clustering in embedding space.
Qishi Dong, Zijian Huang, Xuanwu Wang, Zhenghui Feng, Wei Liu, Bingding Huang   +5 more
wiley   +1 more source

3-D reconstruction of a human fetus with combined holoprosencephaly and cyclopia

Head & Face Medicine, 2009
Background The purpose of this study was to examine a human fetus with combined holoprosencephaly and cyclopia by means of histology and 3-D reconstruction to determine the internal structure and extent of the malformation.
Meiselbach Veronika, Arnold Wolfgang H
doaj   +1 more source

The 9th International RASopathies Symposium

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The RASopathies are a group of congenital disorders with overlapping clinical manifestations that are caused by pathogenic germline or early somatic variants that result in the hyperactivation of the RAS/mitogen‐activated protein kinase (MAPK) signaling pathway.
Pau Castel, Lisa Schoyer, Beth Stronach, Raya Bogdanova, Anton M. Bennett, Jaishri Blakeley, Miriam Bornhorst, Tammy Bowers, Saskia M. Brachmann, Emma Burkitt‐Wright, Kathryn Chatfield, Alessandro De Luca, Khalil El‐Chammas, Abdul Elkadri, John E. Fortunato, Bruce D. Gelb, Anne Goriely, Karen Gripp, Kassidy Grover, Lindsay Homan, Kenneth A. Kern, Maija Kiuru, Charles (Chuck) Lawson, Yong‐Seok Lee, Frank McCormick, Gina Ney, Cristina Nuevo‐Tapioles, Sara Pardej, Elizabeth I. Pierpont, Julia Plank, Nancy Ratner, Katherine A. Rauen, J. Elliott Robinson, Les Rogers, Sarah E. Sheppard, Keir Shiels, David Stevenson, Dagmar Tiemens, Matthew Traylor, K. Nicole Weaver, Marielle Yohe, Tamar Green   +41 more
wiley   +1 more source

Expression pattern of the thrombopoietin receptor (Mpl) in the murine central nervous system [PDF]

, 2010
Background Thrombopoietin (Thpo) and its receptor (Mpl), which regulate megakaryopoiesis, are expressed in the central nervous system (CNS), where Thpo is thought to exert pro-apoptotic effects on newly generated neurons.
Anna Ivanova, Jens Wuerfel, Juan Zhang, Olaf Hoffmann, Matthias Ballmaier, Christof Dame   +5 more
core   +1 more source

Construction of pathogenic Sec16a mutation mouse model using CRISPR/Cas9

Animal Models and Experimental Medicine, EarlyView.
Yaqiang Hu et al. engineered a pathogenic Sec16a mutant mouse model using CRISPR/Cas9 technology. They observed that the Sec16a mutant mice displayed diminished learning and memory capabilities, along with a limb‐clasping phenotype upon tail suspension.
Yaqiang Hu, Zhiyang Zeng, Xinyu Ming, Shuming Yin, Yuting Guan, Liangcai Gao, Dali Li   +6 more
wiley   +1 more source

Role for TGF-beta superfamily signaling in telencephalic GABAergic neuron development. [PDF]

, 2010
Signaling mechanisms mediated by the Transforming Growth Factor-beta (TGF-beta) superfamily regulate a variety of developmental processes. Here we show that components of both bone morphogenetic protein/growth differentiation factor and TGF-beta/activin ...
Lee, Amie Y, Long, Jason E, Maira, Mario, Rubenstein, John LR, Stifani, Stefano   +4 more
core  

Schizencephaly—diagnostics and clinical dilemmas [PDF]

, 2015
Background Schizencephaly is an uncommon congenital disorder of cerebral cortical development. The defect is characterized by the presence of a cleft in the brain extending from the surface of the pia mater to the cerebral ventricles.
Agata Halabuda, Aleksandra Gergont, Lukasz Klasa, Lukasz Wyrobek, Olga Milczarek, Stanislaw Kwiatkowski   +5 more
core   +2 more sources

Scalp electroacupuncture targeting trigeminal nerve activation alleviates post‐traumatic stress disorder–induced depression and neuroinflammation in mice

Animal Models and Experimental Medicine, EarlyView.
Scalp electroacupuncture (SA) through activation of the trigeminal pathway exerts anti‐inflammatory, antidepressant, and anxiolytic effects in an animal model of post‐traumatic stress disorder induced by single prolonged stress. This suggests that SA is involved in neuroinflammation and changes in brain‐derived neurotrophic factor protein through the ...
Bombi Lee, Yoongeum Kim, Hyungjun Kim, Dae‐Hyun Hahm   +3 more
wiley   +1 more source

Emergence of neuronal diversity from patterning of telencephalic progenitors. [PDF]

, 2015
During central nervous system (CNS) development, hundreds of distinct neuronal subtypes are generated from a single layer of multipotent neuroepithelial progenitor cells.
Alexandre, Anderson, Andoniadou, Andoniadou, Andoniadou, Angevine, Anthony, Armentano, Assimacopoulos, Azim, Bachler, Backman, Balaskas, Batista-Brito, Bishop, Bishop, Borello, Borello, Borrell, Braun, Briscoe, Britanova, Brown, Bulchand, Bultje, Butt, Butt, Carlin, Caronia-Brown, Caviness, Chen, Chiang, Cho, Cholfin, Cholfin, Chou, Ciceri, Cohen, Corbin, Cubelos, Cubelos, Dong, Du, Durston, Ericson, Faedo, Faedo, Fairen, Fietz, Flames, Flandin, Fode, Fogarty, Fragkouli, Franco, Franco, Frantz, Fuccillo, Fukuchi-Shimogori, Gal, Gao, Garel, Gimeno, Gotz, Graybiel, Greig, Guillemot, Gunhaga, Gunhaga, Guo, Gutin, Hamasaki, Hansen, Harrison-Uy, Hasegawa, Hayhurst, Hevner, Hoch, Houart, Inoue, Kanatani, Kohtz, Kohwi, Korematsu, Kornack, Kowalczyk, Kreitzer, Kuschel, Kwan, Lagutin, Lavdas, Lehtinen, Liodis, Lopes, Lui, Luskin, Macdonald, Malatesta, Mangale, Marin, Martinez-Barbera, Maruoka, McEvilly, McWhirter, Miller, Miller, Miyoshi, Miyoshi, Mizutani, Molyneaux, Molyneaux, Monuki, Muzio, Muzio, Muzio, Nieto, O'Leary, O'Leary, O'Leary, O'Leary, O'Leary, Pattabiraman, Pei, Pilz, Rakic, Rakic, Rakic, Rallu, Rallu, Rash, Ribes, Sahara, Saulnier, Sessa, Sestan, Seuntjens, Shen, Shimamura, Shimogori, Shinya, Shitamukai, Sousa, Sousa, Stancik, Stenman, Storm, Subramanian, Sugitani, Sur, Sussel, Terakawa, Theil, Toresson, Toyoda, Valcanis, Vierbuchen, Vierbuchen, Waclaw, Walsh, Walshe, Wang, Weimann, Wichterle, Wichterle, Wonders, Wonders, Xie, Xu, Xu, Xuan, Yoon, Yu, Yu, Zembrzycki, Zhao, Zhao   +175 more
core   +3 more sources