Simultaneous monitoring of the two coupled motors of a single FoF1-ATP synthase by three-color FRET using duty cycle-optimized triple-ALEX [PDF]
FoF1-ATP synthase is the enzyme that provides the 'chemical energy currency' adenosine triphosphate, ATP, for living cells. The formation of ATP is accomplished by a stepwise internal rotation of subunits within the enzyme. Briefly, proton translocation through the membrane-bound Fo part of ATP synthase drives a 10-step rotary motion of the ring of c ...
arxiv +1 more source
Broccoli and Arthritis: A Review
A dietary supplement of broccoli holds potential as a preventive measure against arthritis due to its widespread popularity, safety profile, and affordability. In this systematic review, we have compiled and summarized relevant literature regarding the effects of broccoli and its major bioactive components on arthritis, along with the underlying ...
Mingyuan Song+5 more
wiley +1 more source
Monitoring subunit rotation in single FRET-labeled FoF1-ATP synthase in an anti-Brownian electrokinetic trap [PDF]
FoF1-ATP synthase is the membrane protein catalyzing the synthesis of the 'biological energy currency' adenosine triphosphate (ATP). The enzyme uses internal subunit rotation for the mechanochemical conversion of a proton motive force to the chemical bond.
arxiv +1 more source
36 degree step size of proton-driven c-ring rotation in FoF1-ATP synthase [PDF]
Synthesis of the biological "energy currency molecule" adenosine triphosphate ATP is accomplished by FoF1-ATP synthase. In the plasma membrane of Escherichia coli, proton-driven rotation of a ring of 10 c subunits in the Fo motor powers catalysis in the F1 motor. While F1 uses 120 degree stepping, Fo models predict a step-by-step rotation of c subunits
arxiv
Optimized green fluorescent protein fused to FoF1-ATP synthase for single-molecule FRET using a fast anti-Brownian electrokinetic trap [PDF]
Observation times of freely diffusing single molecules in solution are limited by the photophysics of the attached fluorescence markers and by a small observation volume in the femtolitre range that is required for a sufficient signal-to-background ratio. To extend diffusion-limited observation times through a confocal detection volume, A. E. Cohen and
arxiv +1 more source
Nonsteroidal anti-inflammatory drugs ameliorate pain and fever by inhibiting cyclooxygenase (COX) and suppressing prostanoid formation. Microsomal prostaglandin E synthase-1 (mPGES-1) catalyzes formation of PGE2 from the COX product PGH2 and has emerged ...
Miao Wang+12 more
semanticscholar +1 more source
Prostaglandins are involved in the regulation of several reproductive processes such as ovulation, luteolysis, and establishment of pregnancy. Prostaglandin E2 (PGE2) appears to favor establishment of pregnancy in most mammals studied so far. The primary
J. Parent, M. Fortier
semanticscholar +1 more source
Asymmetry of rotational catalysis of single membrane-bound F0F1-ATP synthase [PDF]
Erroneous submission in violation of copyright removed by arXiv admin.
arxiv
Protein glycosylation in lung cancer from a mass spectrometry perspective
Abstract Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi+2 more
wiley +1 more source
Effect of Natural Polyphenols on Breast Cancer Chemoprevention and Treatment
Effect of Natural Polyphenols on Breast Cancer proliferation and progression. ABSTRACT Breast cancer is the most common type of malignancy among women worldwide. Significant achievements have been made in diagnostic tools and cancer treatments in the past decade; however, the complexity and heterogeneity of certain breast cancer subtypes often lead to ...
Marzia Sichetti+4 more
wiley +1 more source