Results 111 to 120 of about 71,694 (241)

Low‐Intensity Focused Ultrasound‐Responsive Nanobubbles Enhance Thrombus Targeting and Penetration for Highly Effective Thrombolytic Therapy

Small Structures, EarlyView.
Low‐intensity focused ultrasound (LIFU)‐responsive nanobubbles (PAF@M) specifically target thrombus sites and penetrate thrombi under LIFU stimulation. Meanwhile, the liquid–gas phase transition of perfluoropentane and the release of nitric oxide synergistically enhance ultrasonic cavitation to destroy thrombus structure, providing a safe and effective
Wenli Zhang, Maoyuan Sun, Lian Xu, Sijin Chen, Xiyue Rong, Junrui Wang, Jia Liu, Bo Liu, Jie Xu, Ying Luo, Qianying Du, Yi Wang, Yun Liu, Zhigang Wang, Haitao Ran, Dajing Guo   +15 more
wiley   +1 more source

Regulation of the microsomal prostaglandin E synthase‐1 in polarized mononuclear phagocytes and its constitutive expression in neutrophils

Journal of Leukocyte Biology, 2007
PGs are potent mediators of pain and inflammation. PGE synthases (PGES) catalyze the isomerization of PGH2 into PGE2. The microsomal (m)PGES‐1 isoform serves as an inducible PGES and is responsible for the production of PGE2, which mediates acute pain in
M. Mosca, N. Polentarutti, G. Mangano, C. Apicella, A. Doni, F. Mancini, M. De Bortoli, I. Coletta, L. Polenzani, G. Santoni, M. Sironi, A. Vecchi, A. Mantovani   +12 more
semanticscholar   +1 more source

Selection of best randomized controlled trials of Japanese Kampo medicines: Introduction of the trials and the hardships in their conduction

Traditional &Kampo Medicine, EarlyView.
Abstract Background More than 500 randomized controlled trials (RCTs) were selected from various databases by the evidence‐based medicine committee of the Japan Society for Oriental Medicine (JSOM). Their structured abstracts have been published in Japanese and English in “Evidence Reports of Kampo Treatment.” Methods From among these RCTs, “Kampo Best
Yoshiharu Motoo, Kazunari Tominaga, Hidekazu Suzuki, Toshimi Kaido, Chu Matsuda, Satoshi Morita, Toshiaki Kogure, Ichiro Arai, Kiichiro Tsutani   +8 more
wiley   +1 more source

Imaging cytochrome C oxidase and FoF1-ATP synthase in mitochondrial cristae of living human cells by FLIM and superresolution microscopy [PDF]

arXiv, 2017
Cytochrome C oxidase and FoF1-ATP synthase constitute complex IV and V, respectively, of the five membrane-bound enzymes in mitochondria comprising the respiratory chain. These enzymes are located in the inner mitochondrial membrane (IMM), which exhibits large invaginations called cristae.
arxiv  

Overexpression of Functionally Coupled Cyclooxygenase-2 and Prostaglandin E Synthase in Symptomatic Atherosclerotic Plaques as a Basis of Prostaglandin E ₂ -Dependent Plaque Instability [PDF]

, 2001
Francesco Cipollone, Cesaria Prontera, Barbara Pini, Matteo Marini, Maria Fazia, Domenico De Cesare, Annalisa Iezzi, S Ucchino, Gianfranco Boccoli, Vittorio Saba, Francesco Chiarelli, Franco Cuccurullo, Andrea Mezzetti   +12 more
openalex   +1 more source

Membrane-Bound Prostaglandin E Synthase-1-Mediated Prostaglandin E2 Production by Osteoblast Plays a Critical Role in Lipopolysaccharide-Induced Bone Loss Associated with Inflammation

Journal of Immunology, 2006
PGE2 acts as a potent stimulator of bone resorption in several disorders including osteoarthritis and periodontitis. Three PGE synthases (PGES) were isolated for PGE2 production, but which PGES has the major role in inflammatory bone resorption is still ...
Masaki Inada, Chiho Matsumoto, S. Uematsu, S. Akira, C. Miyaura   +4 more
semanticscholar   +1 more source

Emerging trends in the management of non‐obstructive azoospermia

UroPrecision, EarlyView.
Abstract Ten percent of infertile males have azoospermia, classified into obstructive and nonobstructive types, which require specific medical or surgical treatments. In nonobstructive azoospermia, advancements in microsurgery allow for effective sperm retrieval in about half of cases.
Mina Saad, Mohamed Alkabeer, Dina Abdelmonim, Sameh Fayek GamalElDin, Mohamed Wael Ragab   +4 more
wiley   +1 more source

Coexpression of Microsomal-Type Prostaglandin E Synthase with Cyclooxygenase-2 in Brain Endothelial Cells of Rats during Endotoxin-Induced Fever [PDF]

, 2001
Kanato Yamagata, Kiyoshi Matsumura, Wataru Inoue, Takuma Shiraki, Kyoko Suzuki, Shin Yasuda, Hiroko Sugiura, Chunyu Cao, Yasuyoshi Watanabe, Shígeo Kobayashi   +9 more
openalex   +1 more source

Lipopolysaccharide-Induced Increase of Prostaglandin E2 Is Mediated by Inducible Nitric Oxide Synthase Activation of the Constitutive Cyclooxygenase and Induction of Membrane-Associated Prostaglandin E Synthase1

Journal of Immunology, 2001
NO produced by the inducible NO synthase (NOS2) and prostanoids generated by the cyclooxygenase (COX) isoforms and terminal prostanoid synthases are major components of the host innate immune and inflammatory response.
Y. Devaux, C. Seguin, S. Grosjean, N. de Talancé, Viviane Camaeti, A. Burlet, F. Zannad, C. Meistelman, P. Mertes, D. Longrois   +9 more
semanticscholar   +1 more source

Microsomal Prostaglandin E Synthase Is Regulated by Proinflammatory Cytokines and Glucocorticoids in Primary Rheumatoid Synovial Cells [PDF]

, 2001
Dirk O. Stichtenoth, Staffan Thorén, Huimin Bian, Marc Peters‐Golden, Per‐Johan Jakobsson, Leslie J. Crofford   +5 more
openalex   +1 more source