Acta Physiologica, Volume 241, Issue 7, July 2025.ABSTRACT Aim Timely myocardial reperfusion is essential for restoring blood flow to post‐ischemic tissue, thereby reducing cardiac injury and limiting infarct size. However, this process can paradoxically result in additional, irreversible myocardial damage, known as myocardial ischemia–reperfusion injury (MIRI).
Anna De Bartolo +3 more
wiley +1 more source
5-methyl-2-carboxamidepyrrole-based novel dual mPGES-1/sEH inhibitors as promising anticancer candidates. [PDF]
Arch Pharm (Weinheim)Colarusso E +13 more
europepmc +1 more source
p‐Cresol and p‐Cresyl Sulphate Boost Oxidative Stress: A Systematic Review of Recent Evidence
Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 1, July 2025.ABSTRACT Recent studies have emphasized the significant role of p‐cresol and its conjugated form, p‐cresyl sulphate (PCS), in enhancing oxidative stress, leading to potential detrimental effects on various biological systems. Both p‐cresol and PCS contribute to increased production of reactive oxygen species (ROS), which can result in tissue damage ...
Rinvil Renaldi +3 more
wiley +1 more source
Differential Gene and Protein Expressions Responsible for Vasomotor Signaling Provide Mechanistic Bases for the Opposite Flow-Induced Responses of Pre- and Post-Circle of Willis Arteries. [PDF]
Life (Basel)Nemeth Z, Eros K, Munkacsy G, Koller A.
europepmc +1 more source
Targeting Regulation of Macrophage to Treat Metabolic Disease: Role of Phytochemicals
Cell Proliferation, Volume 58, Issue 7, July 2025.One‐third of the world's population is affected by metabolic syndrome. Complicated pathogenesis and limited drugs cause the growing prevalence of metabolic syndrome. Macrophage‐mediated metaflammation is closely associated with the development of metabolic syndrome. The role of phytochemicals targeting macrophages in the treatment of metabolic syndrome
Zeting Ye +6 more
wiley +1 more source
Role of Nitric Oxide Synthases in Respiratory Health and Disease: Insights from Triple Nitric Oxide Synthases Knockout Mice. [PDF]
Int J Mol SciOgoshi T, Yatera K, Mukae H, Tsutsui M.
europepmc +1 more source
Pathogenesis of Melasma Explained
International Journal of Dermatology, Volume 64, Issue 7, Page 1201-1212, July 2025.Pathophysiology of melasma. ABSTRACT This review provides an in‐depth analysis of the pathophysiology of melasma and highlights recent studies that elucidate its underlying mechanisms. Given the prevalence of melasma, a thorough understanding of its pathogenesis is critical for the development of effective treatment strategies.
Lara Ali, Firas Al Niaimi
wiley +1 more source
Omega-6 polyunsaturated fatty acids and their metabolites: a potential targeted therapy for pulmonary hypertension. [PDF]
Respir ResWang J, Hu S, Xu Y, Wang T.
europepmc +1 more source