Results 41 to 50 of about 78,509 (319)
Animals, 2019 Keel fracture has negative effects on the health and welfare of laying hens. We investigated effects of keel fracture on stress, inflammation, and the orexin system in laying hens.
Haidong Wei +8 more
doaj +1 more source
In Silico screening of nonsteroidal anti-inflammatory drugs and their combined action on Prostaglandin H Synthase-1 [PDF]
, 2010 The detailed kinetic model of Prostaglandin H Synthase-1 (PGHS-1) was applied to in silico screening of dose-dependencies for the different types of nonsteroidal anti-inflammatory drugs (NSAIDs), such as: reversible/irreversible, nonselective/selective ...
Demin, Oleg +5 more
core +4 more sources
Prostaglandin E synthase is regulated in postnatal mouse testis
Frontiers in Bioscience, 2012 Prostaglandins have important roles in the male reproductive system. In this study, we report on the distribution and regulation of cPGES during postnatal development of mouse testis. The expression of cPGES was weak in testis 5 days after birth and increased through the 10th and 15th day.
Weihua Kong +4 more
openaire +3 more sources
Vasoconstrictor prostanoids [PDF]
, 2010 In cardiovascular diseases and during aging, endothelial dysfunction is due in part to the release of endothelium-derived contracting factors that counteract the vasodilator effect of the nitric oxide.
Félétou, M, Huang, Y, Vanhoutte, PM
core +1 more source
Reproduction, 2009 To determine if changes in endometrial expression of the enzymes and receptors involved in prostaglandin (PG) synthesis and action might provide insights into the PGs involved in the initiation of decidualization, ovariectomized steroid-treated rats at ...
C. Gillio-Meina +4 more
semanticscholar +1 more source
Elevated microsomal prostaglandin‐E synthase‐1 in Alzheimer's disease [PDF]
Alzheimer's & Dementia, 2007 BackgroundThe proinflammatory prostaglandin E2 (PGE2) fluctuates over time in the cerebrospinal fluid of patients with Alzheimer's disease (AD), but the cerebral distribution and expression patterns of microsomal prostaglandin‐E synthase (mPGES)–1 have not been compared with those of normal human brains.MethodsMiddle frontal gyrus tissue from AD and ...
Sylvain Doré +3 more
openaire +3 more sources
Prostaglandins induce early growth response 1 transcription factor mediated microsomal prostaglandin E2 synthase up-regulation for colorectal cancer progression [PDF]
, 2016 Cyclooxygenase2 (COX2) has been associated with cell growth, invasiveness, tumor progression and metastasis of colorectal carcinomas. However, the downstream prostaglandin (PG)-PG receptor pathway involved in these effects is poorly characterized.
Fresno, Manuel, Stamatakis, Konstantinos
core +1 more source
Endothelial dysfunction: A strategic target in the treatment of hypertension? [PDF]
, 2010 Endothelial dysfunction is a common feature of hypertension, and it results from the imbalanced release of endothelium-derived relaxing factors (EDRFs; in particular, nitric oxide) and endothelium-derived contracting factors (EDCFs; angiotensin II ...
Tang, EHC, Vanhoutte, PM
core +1 more source
Journal of Endocrinology, 2006 Prostaglandin (PGE) 2 is the most common prostanoid and plays an important role in female reproduction. The aim of this study was to examine the expression and regulation of microsomal (m) PGE synthase (PGES)-1 and cytosolic (c) PGES in the mouse ovary ...
T. Sun +7 more
semanticscholar +1 more source
Inducible Prostaglandin E Synthase as a Pharmacological Target for Ischemic Stroke
Neurotherapeutics, 2022 As the inducible terminal enzyme for prostaglandin E2 (PGE2) synthesis, microsomal PGE synthase-1 (mPGES-1) contributes to neuroinflammation and secondary brain injury after cerebral ischemia via producing excessive PGE2. However, a proof of concept that mPGES-1 is a therapeutic target for ischemic stroke has not been established by a pharmacological ...
Lexiao Li +7 more
openaire +2 more sources