Results 41 to 50 of about 71,694 (241)

Signal pathways JNK and NF-κB, identified by global gene expression profiling, are involved in regulation of TNFα-induced mPGES-1 and COX-2 expression in gingival fibroblasts

BMC Genomics, 2010
Background Prostaglandin E2 (PGE2) is involved in several chronic inflammatory diseases including periodontitis, which causes loss of the gingival tissue and alveolar bone supporting the teeth. We have previously shown that tumor necrosis factor α (TNFα)
Modéer Thomas, Lundeberg Joakim, Lindberg Johan, Båge Tove, Yucel-Lindberg Tülay   +4 more
doaj   +1 more source

Inducible Prostaglandin E Synthase as a Pharmacological Target for Ischemic Stroke

Neurotherapeutics, 2022
As the inducible terminal enzyme for prostaglandin E2 (PGE2) synthesis, microsomal PGE synthase-1 (mPGES-1) contributes to neuroinflammation and secondary brain injury after cerebral ischemia via producing excessive PGE2. However, a proof of concept that mPGES-1 is a therapeutic target for ischemic stroke has not been established by a pharmacological ...
Lexiao Li, Nelufar Yasmen, Ruida Hou, Seyoung Yang, Jae Yeol Lee, Jiukuan Hao, Ying Yu, Jianxiong Jiang   +7 more
openaire   +3 more sources

Extensive Molecular Dynamics Simulations Disclosed the Stability of mPGES‐1 Enzyme and the Structural Role of Glutathione (GSH) Cofactor

Molecular Informatics, Volume 41, Issue 12, December 2022., 2022
Abstract A deep in silico investigation of various microsomal prostaglandin E2 synthase‐1 (mPGES‐1) protein systems is here reported using molecular dynamics (MD) simulations. Firstly, eight different proteins models (Models A−H) were built, starting from the active enzyme trimer system (Model A), namely that bound to three glutathione (GSH) cofactor ...
Simone Di Micco, Gianluigi Lauro, Giuseppe Bifulco   +2 more
wiley   +1 more source

Resveratrol inhibits prostaglandin formation in IL-1β-stimulated SK-N-SH neuronal cells

Journal of Neuroinflammation, 2009
Resveratrol, a polyphenol present in grapes and red wine, has been studied due to its vast pharmacological activity. It has been demonstrated that resveratrol inhibits production of inflammatory mediators in different in vitro and in vivo models.
Candelario-Jalil Eduardo, Bhatia Harsharan S, de Oliveira Antonio, Wendeburg Lena, Fiebich Bernd L   +4 more
doaj   +1 more source

Keel Fracture Causes Stress and Inflammatory Responses and Inhibits the Expression of the Orexin System in Laying Hens

Animals, 2019
Keel fracture has negative effects on the health and welfare of laying hens. We investigated effects of keel fracture on stress, inflammation, and the orexin system in laying hens.
Haidong Wei, Chun Li, Hongwei Xin, Shuang Li, Yanju Bi, Xiang Li, Jianhong Li, Runxiang Zhang, Jun Bao   +8 more
doaj   +1 more source

Prostaglandin E synthase is regulated in postnatal mouse testis

Frontiers in Bioscience, 2012
Prostaglandins have important roles in the male reproductive system. In this study, we report on the distribution and regulation of cPGES during postnatal development of mouse testis. The expression of cPGES was weak in testis 5 days after birth and increased through the 10th and 15th day.
Weihua Kong, Yi Du, Yanjun Zhang, Renwei Jing, Dengyu Wang   +4 more
openaire   +3 more sources

Expression patterns and role of prostaglandin-endoperoxide synthases, prostaglandin E synthases, prostacyclin synthase, prostacyclin receptor, peroxisome proliferator-activated receptor delta and retinoid x receptor alpha in rat endometrium during artificially-induced decidualization.

Reproduction, 2009
To determine if changes in endometrial expression of the enzymes and receptors involved in prostaglandin (PG) synthesis and action might provide insights into the PGs involved in the initiation of decidualization, ovariectomized steroid-treated rats at ...
C. Gillio-Meina, S. Phang, J. P. Mather, Brian S. Knight, T. Kennedy   +4 more
semanticscholar   +1 more source

Elevated microsomal prostaglandin‐E synthase‐1 in Alzheimer's disease [PDF]

Alzheimer's & Dementia, 2007
BackgroundThe proinflammatory prostaglandin E2 (PGE2) fluctuates over time in the cerebrospinal fluid of patients with Alzheimer's disease (AD), but the cerebral distribution and expression patterns of microsomal prostaglandin‐E synthase (mPGES)–1 have not been compared with those of normal human brains.MethodsMiddle frontal gyrus tissue from AD and ...
Sylvain Doré, Barbara J. Crain, Uzma A. Chaudhry, Hean Zhuang   +3 more
openaire   +3 more sources

Effect of omega‐3 polyunsaturated fatty acid supplementation on oxidative stress parameters and sex hormone levels of modern genotype sows

Veterinary Medicine and Science, Volume 9, Issue 1, Page 191-202, January 2023., 2023
In this study, we supplemented the diet of breeding sows either with omega‐6 (control) or omega‐3 (experimental) polyunsaturated fatty acids and examined their effects on the antioxidant system and hormone levels of the animals. In the blood levels of molecules indicating oxidative stress we experienced slight changes, but the feeding of omega‐3 fatty ...
Róbert Roszkos, Tamás Tóth, George Bazar, Hedvig Fébel, Miklós Mézes   +4 more
wiley   +1 more source

Diffusion properties of single FoF1-ATP synthases in a living bacterium unraveled by localization microscopy [PDF]

, 2012
FoF1-ATP synthases in Escherichia coli (E. coli) bacteria are membrane-bound enzymes which use an internal proton-driven rotary double motor to catalyze the synthesis of adenosine triphosphate (ATP). According to the 'chemiosmotic hypothesis', a series of proton pumps generate the necessary pH difference plus an electric potential across the bacterial ...
arxiv   +1 more source