Results 61 to 70 of about 71,694 (241)

Myeloid cell microsomal prostaglandin E synthase-1 fosters atherogenesis in mice

Proceedings of the National Academy of Sciences of the United States of America, 2014
Significance Inhibitors of microsomal prostaglandin E synthase-1 (mPGES-1) are being developed as analgesics. Although global depletion of mPGES-1 suggests they will be less likely to confer a cardiovascular hazard than NSAIDs selective for inhibition of
Lihong Chen, Guangrui Yang, James Monslow, Leslie Todd, D. Cormode, Jun Tang, G. Grant, J. DeLong, S. Tang, J. Lawson, E. Puré, G. FitzGerald   +11 more
semanticscholar   +1 more source

The Encapsulation Strategies for Targeted Delivery of Probiotics in Preventing and Treating Colorectal Cancer: A Review

Advanced Science, EarlyView.
This work summarizes the efficacy and mechanisms of probiotics in CRC treatment, providing a comprehensive overview of various encapsulation methods such as microcapsules, hydrogels, single‐cell nanocoatings, and nanofibers for targeted probiotic delivery to inflammatory sites, with particular emphasis on the potential advantages of emerging single ...
Hao Zhong, Jin Jiang, Muhammad Hussain, Haoxuan Zhang, Ling Chen, Rongfa Guan   +5 more
wiley   +1 more source

Detecting substeps in the rotary motors of FoF1-ATP synthase by Hidden Markov Models [PDF]

, 2007
FoF1-ATP synthase is the enzyme that provides the 'chemical energy currency' adenosine triphosphate, ATP, for living cells. The formation of ATP is accomplished by a stepwise internal rotation of subunits within the enzyme. We monitor subunit rotation by a single-molecule fluorescence resonance energy transfer (FRET) approach using two fluorophores ...
arxiv   +1 more source

Expression profiles of interferon‐stimulated gene 15 and prostaglandin synthases in the ovine lymph nodes during early pregnancy

Molecular Reproduction and Development, 2018
Lymph nodes are distributed all over the body and are part of the lymphatic system. The interferon‐stimulated gene 15 kDa protein (ISG15) and prostaglandins (PGs) are involved in the establishment of pregnancy and are expressed in the uterus during early
Ling Yang, Qingkai Wang, Yong Liu, Leying Zhang, Wan Lv, Baolian Liu   +5 more
semanticscholar   +1 more source

Mechanical Biomimetic Nanocomposites for Multidimensional Treatment of Arterial Thrombosis

Advanced Science, EarlyView.
In this study, a mechanical biomimetic nanocomposite is developed, guided by photoacoustic imaging, to achieve highly efficient and safe thrombolysis through the synergistic effects of photothermal therapy and pharmacological intervention. Most notably, the nanoparticle improves the microenvironment of arterial thrombi, marked by high shear stress and ...
Ying Li, Qi Xiang, Yan Zhang, Fuxue Luo, Yunfang Wu, Haitao Ran, Yang Cao   +6 more
wiley   +1 more source

Monitoring the rotary motors of single FoF1-ATP synthase by synchronized multi channel TCSPC [PDF]

, 2007
Confocal time resolved single-molecule spectroscopy using pulsed laser excitation and synchronized multi channel time correlated single photon counting (TCSPC) provides detailed information about the conformational changes of a biological motor in real time.
arxiv   +1 more source

Modeling work-speed-accuracy trade-offs in a stochastic rotary machine [PDF]

Phys. Rev. E 101, 032110 (2020), 2019
Molecular machines are stochastic systems that catalyze the energetic processes keeping living cells alive and structured. Inspired by the examples of F1-ATP synthase and the bacterial flagellum, we present a minimal model of an externally driven stochastic rotary machine.
arxiv   +1 more source

Changes in the expression of prostaglandin E and F synthases at induced and spontaneous labour onset in the sheep.

Journal of Endocrinology, 2004
The differential production of prostaglandin (PG) F(2 alpha) and PGE(2) within the uterine compartment may play a role in controlling myometrial contraction. We hypothesized that the enzymes downstream of PG endoperoxide synthase-2 (PGHS-2) determine the
H. Palliser, G. Ooi, Jonathan J. Hirst, G. E. Rice, Nicole L. Dellios, Ruth M. Escalona, I. Young   +6 more
semanticscholar   +1 more source

Patchouli Ethanol Extract Pogostemon cablin Benth. Against Aging Profiles in Doxorubicin‐Induced 3T3‐L1 Fibroblast Cell Lines

AGING MEDICINE, EarlyView.
Pogostemon cablin Benth. (PCEE) is a promising antiaging agent that inhibits ROS, decreases the senescence‐associated β‐galactosidase (SA‐β‐gal) gene, and maintains telomere length in doxorubicin‐induced 3T3‐L1 fibroblast cells. The researchers extend their gratitude to www.freepik.com for providing Figure telomer.
Teguh Santoso, Astrid Feinisa Khairani, Muhammad Hasan Bashari, Julia Ramadhanti, Enny Rohmawati, Monika Pury Oktora, Hesti Lina Wiraswati   +6 more
wiley   +1 more source

Integrating Aggregate Materials and Machine Learning Algorithms: Advancing Detection of Pathogen‐Derived Extracellular Vesicles

Aggregate, EarlyView.
Pathogen‐derived extracellular vesicle detection: theoretical insights and advanced methodologies: This review explores the theoretical foundations and practical applications of pEV detection, emphasizing the challenges and innovative strategies involving novel aggregate materials and machine learning for enhanced diagnostic accuracy.
Lihan Lai, Yun Su, Cong Hu, Zehong Peng, Wei Xue, Liang Dong, Tony Y. Hu   +6 more
wiley   +1 more source