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Prostaglandin pathways in equine myometrium regulations: endometrosis progression [PDF]
Frontiers in Veterinary ScienceIntroductionProstaglandins (PG) are important regulators of the myometrial contractility in mammals. Endometrosis, a condition characterized by morphological changes in the equine endometrium, also affects endometrial secretory function.
Katarzyna K. Piotrowska-Tomala +9 more
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Prostaglandin Endoperoxide H Synthases [PDF]
Journal of Biological Chemistry, 2007 The cyclooxygenase (COX) activity of prostaglandin endoperoxide H synthases (PGHSs) converts arachidonic acid and O2 to prostaglandin G2 (PGG2). PGHS peroxidase (POX) activity reduces PGG2 to PGH2. The first step in POX catalysis is formation of an oxyferryl heme radical cation (Compound I), which undergoes intramolecular electron transfer forming ...
Jiayan Liu +5 more
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Prostaglandin endoperoxide synthase contains an EGF‐like domain [PDF]
FEBS Letters, 1989 Prostaglandin endoperoxide synthase was subjected to the computer‐assisted homology search in the protein primary structure database, in order to investigate the regulation mechanism of the expression of prostaglandin endoperoxide synthase. As a result of that, it turned out that prostaglandin endoperoxide synthase shares sequence homology with ...
Hiroyuki Toh
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The orientation of prostaglandin endoperoxide synthases-1 and -2 in the endoplasmic reticulum.
Journal of Biological Chemistry, 1994 Prostaglandin endoperoxide H synthases (PGHS)-1 and -2 are integral membrane proteins of the endoplasmic reticulum (ER). The luminal versus cytoplasmic orientations of several epitopes of PGHS-1 and PGHS-2 were determined by immunocytofluorescent staining of cells following treatment with membrane-selective permeants.
James Otto, William L. Smith
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Unraveling the Mechanism of Xiaochaihu Granules in Alleviating Yeast-Induced Fever Based on Network Analysis and Experimental Validation [PDF]
PharmaceuticalsXiaochaihu granules (XCHG) are extensively used to treat fever. Nevertheless, the underlying mechanism remains elusive. This study aimed to explore the potential of XCHG in mitigating yeast-induced fever and the underlying metabolic pathways.
Xiuli Chen +10 more
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Association between two single nucleotide polymorphisms of the Prostaglandin-Endoperoxide Synthase 1 and 2 genes and cell proliferative prostatic diseases in Lebanon. [PDF]
OncotargetSheehan BJ +6 more
europepmc +2 more sources
Gynecology Obstetrics & Reproductive Medicine, 2021 Objective: To evaluate the correlation between the gene expression of prostaglandin-endoperoxide synthase-2 in the cumulus-oocyte complex with the level of prostaglandin-endoperoxide synthase-2 in follicular fluid and follicle diameter, oocyte ...
Goktan Kuspinar, Berrin Avcı
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Cyclooxygenase-2 expression in cervical cancer [PDF]
Vojnosanitetski Pregled, 2014 Background/Aim. Cyclooxygenase (COX) or prostaglandin H2 synthase is the first enzyme that catalyzes the first two steps in the biosynthesis of prostaglandins from arachidonic acid.
Mandić Aljoša +4 more
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Topography of the Prostaglandin Endoperoxide H2 Synthase-2 in Membranes [PDF]
Journal of Biological Chemistry, 2006 The topology of association of the monotopic protein cyclooxygenase-2 (COX-2) with membranes has been examined using EPR spectroscopy of spin-labeled recombinant human COX-2. Twenty-four mutants, each containing a single free cysteine substituted for an amino acid in the COX-2 membrane binding domain were expressed using the baculovirus system and ...
Zahra MirAfzali +3 more
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Nitro-fatty acids: novel anti-inflammatory lipid mediators
Brazilian Journal of Medical and Biological Research, 2013 Nitro-fatty acids are formed and detected in human plasma, cell membranes, and tissue, modulating metabolic as well as inflammatory signaling pathways.
H. Rubbo
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