Frontiers in Neurology, 2017 Activated microglia secrete an array of pro-inflammatory factors, such as prostaglandins, whose accumulation contributes to neuronal damages. Prostaglandin endoperoxide synthases or cyclooxygenases (COX-1 and COX-2), which play a critical role in the ...
Rosa Calvello +10 more
doaj +1 more source
Vasoconstrictor prostanoids [PDF]
, 2010 In cardiovascular diseases and during aging, endothelial dysfunction is due in part to the release of endothelium-derived contracting factors that counteract the vasodilator effect of the nitric oxide.
Félétou, M, Huang, Y, Vanhoutte, PM
core +1 more source
Induction of astrocytic cyclooxygenase-2 in epileptic patients with hippocampal sclerosis [PDF]
, 2003 Induction of cyclooxygenase-2 (COX-2) has been described in a wide range of neurological diseases including animal models of epilepsy. The present study was undertaken to assess COX-2 expression in hippocampal biopsies from patients with therapy ...
Bouthillier, Alain +6 more
core +1 more source
Effect of oleic acid supplementation on prostaglandin production in maternal endometrial and fetal allantochorion cells isolated from late gestation ewes [PDF]
, 2015 Elevated circulating non-esterified fatty acids including oleic acid (OA) are associated with many pregnancy related complications. Prostaglandins (PGs) play crucial roles during parturition.
Aardema +49 more
core +2 more sources
Steroid receptor co-activator interacting protein (SIP) mediates EGF-stimulated expression of the prostaglandin synthase COX2 and prostaglandin release in human myometrium [PDF]
, 2016 Study hypothesis Steroid receptor coactivator interacting protein (SIP/KANK2) is involved in regulating the expression of the prostaglandin (PG)-endoperoxide synthase 2 (PTGS2; also known as cyclo-oxygenase 2, COX2) and PG release in human myometrium ...
Hudson, Claire A +2 more
core +5 more sources
Prostaglandin pathway gene expression in human placenta, amnion and choriodecidua is differentially affected by preterm and term labour and by uterine inflammation [PDF]
, 2014 BACKGROUND: Elucidation of the biochemical pathways involved in activation of preterm and term human labour would facilitate the development of effective management and inform judgements regarding the necessity for preterm tocolysis and post-term ...
Andrés López Bernal +2 more
core +1 more source
Polyunsaturated fatty acid-derived lipid mediators and T cell function [PDF]
, 2014 Copyright © 2014 Nicolaou, Mauro, Urquhart and Marelli-Berg . This is an open- access article distributed under the terms of the Creative Commons Attribution License (CC BY) .
Marelli-Berg, F +3 more
core +3 more sources
Phorbol ester TPA modulates chemoresistance in the drug sensitive breast cancer cell line MCF-7 by inducing expression of drug efflux transporter ABCG2 [PDF]
, 2012 Recent studies have indicated a link between levels of cyclooxygenase-2 (COX-2) and development of the multidrug resistance (MDR) phenotype. The ATP-binding cassette sub-family G member 2 (ABCG2) is a major MDR-related transporter protein that is ...
Behravan, J. +4 more
core +1 more source
Cyclooxygenase and prostaglandins in somatic cell populations of the testis [PDF]
, 2015 rostaglandins (PGs) are synthesized through the action of the rate-limiting enzyme cyclooxygenase (COX) and further specific enzymes. The development of Cox-deficient mice in the 1990s gave insights into the reproductive roles of PGs. Female Cox-knockout
Calandra, Ricardo Saul +3 more
core +1 more source
A role for trypanosomatid aldo-keto reductases in methylglyoxal, prostaglandin and isoprostane metabolism [PDF]
, 2018 Trypanosomatid parasites are the infectious agents causing Chagas’ disease, visceral and cutaneous leishmaniasis and human African trypanosomiasis. Recent work of others has implicated an aldo-keto reductase (AKR) in susceptibility and resistance of ...
Adam J. Roberts +71 more
core +2 more sources