Results 11 to 20 of about 2,860 (168)
Hepatology, EarlyView., 2022 Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog +12 more
wiley +1 more source
Frontiers in Neurology, 2017 Activated microglia secrete an array of pro-inflammatory factors, such as prostaglandins, whose accumulation contributes to neuronal damages. Prostaglandin endoperoxide synthases or cyclooxygenases (COX-1 and COX-2), which play a critical role in the ...
Rosa Calvello +10 more
doaj +1 more source
Resolution of prostaglandin endoperoxide synthase and thromboxane synthase of human platelets. [PDF]
Proceedings of the National Academy of Sciences, 1977 Thromboxane synthase was localized to the microsomes of human platelets. The enzyme was insensitive to sulfhydryl reagents and thiols but was inhibited by 12L-hydroperoxy-5, 8, 10, 14-eicosatetraenoic acid (concentration for 50% inhibition = 0.1 mM).
Sven Hammarström, Pierre Falardeau
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Prostaglandin endoperoxide synthase. The aspirin acetylation region.
Journal of Biological Chemistry, 1992 Aspirin selectively acetylates Ser-530 of prostaglandin endoperoxide (PGH) synthase-1. This causes inactivation of the cyclooxygenase activity of the enzyme, but does not appreciably affect its peroxidase activity. Although the aspirin-acetylated enzyme is inactive, we found that PGH synthase-1 in which Ser-530 had been replaced with an alanine was ...
Teruhiko Shimokawa, William L. Smith
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An Atomically Dispersed Photocatalyst for Undirected para‐Selective C─H Bond Functionalizations
Angewandte Chemie, EarlyView.This study presents an atomically dispersed recyclable heterogeneous photocatalytic method for para‐selective trifluoromethylation of electron‐deficient arenes without directing groups. Unlike previous substrate‐dependent approaches, this recyclable, atomically dispersed photocatalyst enables scalable synthesis of bioactive trifluoromethylated ...
Suman Pradhan +16 more
wiley +2 more sources
Investigation of the role of cysteines in catalysis by prostaglandin endoperoxide synthase. [PDF]
Journal of Biological Chemistry, 1994 The importance of cysteine residues in the cyclooxygenase activity of prostaglandin endoperoxide synthase (PGHS) was investigated using cysteine-specific reagents and site-directed mutagenesis. N-(7-Dimethyl-amino-4-methyl-3-coumarinyl)maleimide (DACM), a hydrophobic maleimide, inactivated both cyclooxygenase and peroxidase activities of apoPGHS in a ...
Lawrence J. Marnett +2 more
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Advanced Science, EarlyView.Lysosomal redistribution occurs via extracellular vesicles in multi‐stem cell aggregates and controls iron homeostasis for safeguarding cell aggregation. These cell aggregate‐released extracellular vesicles (CA‐EVs) rescue lysosomal impairments and exert anti‐ferroptosis effects in recipient irradiated endothelial cells.
Yuan‐Yuan Li +20 more
wiley +1 more source
Advanced Science, EarlyView.Glioblastoma (GBM) is an aggressive brain cancer that often recurs and resists chemotherapy. This study found that a chemical called PGE2 causes surrounding brain cells (neurons) to become over‐excited, which makes GBM cells resistant to treatment. Researchers developed a new drug, “Compound 11,” which can cross into the brain and effectively block ...
Chih‐Jie Shen +14 more
wiley +1 more source
Arthritis &Rheumatology, EarlyView.Objective Chondrocytemetabolic dysfunction plays an important role in osteoarthritis (OA) development during aging and obesity. Protein posttranslational modifications (PTMs) have recently emerged as an important regulator of cellular metabolism. We aim to study one type of PTM, lysine malonylation (MaK), and its regulator sirtuin 5 (Sirt5) in OA ...
Huanhuan Liu +11 more
wiley +1 more source
Exploring Multi‐Organ Crosstalk via the TissUse HUMIMIC Chip System: Lessons Learnt So Far
Biotechnology and Bioengineering, EarlyView.ABSTRACT Three‐dimensional (3D) in vitro cell culture models have revolutionized biomedical research by mimicking the complex 3D in vivo environment in the human body. Different types of 3D models have been established, including heterotypic systems such as, organ‐on‐a‐chips which have been further developed into multiorgan‐on‐chip systems that ...
Filsan Ahmed Abokor +5 more
wiley +1 more source