Results 31 to 40 of about 3,945 (108)

Platelet‐Rich Fibrin Mediates Beneficial Effects on Adipose‐Derived Stem Cells via Increased Levels of Key Cytokines

open access: yesWound Repair and Regeneration, Volume 33, Issue 3, May/June 2025.
ABSTRACT Recent studies showcased the regenerative potential of Platelet‐Rich Fibrin (PRF) combined with Adipose‐Derived Stem Cells (ASC). PRF enhances cellular proliferation through sustained growth factor secretion which are continuously released to surrounding cells. However, its regulatory mechanisms remain unclear.
Nikolaus Wachtel   +7 more
wiley   +1 more source

Therapeutic targeting of TGF‐β in lung cancer

open access: yesThe FEBS Journal, Volume 292, Issue 7, Page 1520-1557, April 2025.
Here, we discuss how lung cancer treatment can be transformed by targeting TGF‐β for better outcomes. Inhibiting TGF‐β signaling halts tumor growth, boosts immune response, and enhances treatment efficacy. By tackling TGF‐β's role in epithelial–mesenchymal transition (EMT) and immune evasion, this approach opens new avenues for more effective lung ...
Sajjad Aftabi   +9 more
wiley   +1 more source

Metabolism and signaling crosstalk in glioblastoma progression and therapy resistance

open access: yesMolecular Oncology, Volume 19, Issue 3, Page 592-613, March 2025.
Glioblastoma is one of the most lethal human cancers with no effective treatment nowadays. Here, we review the increasing amount of evidence supporting the connection between cell signaling deregulation and metabolic reprogramming as a key event in glioblastoma resistance to cancer therapy.
Laura Zarzuela   +2 more
wiley   +1 more source

An antihypertensive lactoferrin hydrolysate inhibits angiotensin I-converting enzyme, modifies expression of hypertension-related genes and enhances nitric oxide production in cultured human endothelial cells [PDF]

open access: yes, 2014
This study was aimed to explore whether an antihypertensive lactoferrin hydrolysate (LFH) can inhibit angiotensin I-converting enzyme (ACE) activity and modify the expression of genes related to hypertension in human umbilical vein endothelial cells ...
Alonso, Eulalia   +5 more
core   +1 more source

Uncovering the Effects and Molecular Mechanisms of Shaoyao Decoction Against Colorectal Cancer Using Network Pharmacology Analysis Coupled With Experimental Validation and Gut Microbiota Analysis

open access: yesCancer Medicine, Volume 14, Issue 6, March 2025.
ABSTRACT Background Chronic gut inflammation and dysbiosis contribute significantly to colorectal cancer (CRC) development. Shaoyao decoction (SYD) is a well‐established Chinese medicine prescription. Besides ameliorating CRC via anti‐inflammatory effects, SYD modulates gut microbiota (GM) to improve inflammatory responses in ulcerative colitis (UC ...
Yaojun Rong   +8 more
wiley   +1 more source

Characterizing the Role of Endocannabinoid Receptor Cnr1 in Mouse Ovarian Granulosa Cells

open access: yesCell Biochemistry and Function, Volume 43, Issue 3, March 2025.
ABSTRACT The endocannabinoid receptors Cnr1 and Cnr2 have been found in reproductive organs such as the oviduct and uterus. These receptors bind to endocannabinoids, the arachinodoylethanolamine (AEA) and arachinodoylglycerol (2‐AG), respectively. Both cannbinoid receptors have been investigated for their role in implantation and fertilization. However,
Jasmine Randhawa   +4 more
wiley   +1 more source

Neuronal and glial prostaglandin D synthase isozymes in chick dorsal root ganglia: a light and electron microscopic immunocytochemical study. [PDF]

open access: yes, 1995
Homogenates of chick dorsal root ganglia (DRG) and in vitro cultures of DRG neurons are known to synthesize prostaglandin (PG) D2. To specify the PGD synthase isozymes controlling PGD2 synthesis in DRG and to identify the DRG cells responsible for this ...
Droz, B.   +3 more
core   +1 more source

Wilms' tumor 1‐associated protein aggravates ischemic stroke by promoting M1 polarization of microglia by enhancing PTGS2 mRNA stability in an m6A‐dependent manner

open access: yesCell Biology International, Volume 49, Issue 3, Page 288-302, March 2025.
Abstract Mounting evidence indicates the involvement of N6‐methyladenosine (m6A) alterations in diverse neurological disorders and the activation of microglia. However, the role of m6A methyltransferase Wilms' tumor 1‐associated protein (WTAP) in regulating microglial polarization during ischemic stroke (IS) remains unknown. We performed bioinformatics
Haijing Sui   +3 more
wiley   +1 more source

Targeting Zfp36 to combat cardiac hypertrophy: Insights into ferroptosis pathways

open access: yesClinical and Translational Medicine, Volume 15, Issue 3, March 2025.
Zinc finger protein 36 bounds to the 3′ untranslated region of Ythdc2 mRNA, facilitating its degradation. Ythdc2 can bind to SLC7A11 mRNA to accelerate its decay, thereby reducing glutathione levels and aggravating ferroptosis‐induced cardiac hypertrophy.
Mingyu Zhang   +16 more
wiley   +1 more source

E74‐like ETS transcription factor 3 expression and regulation in human intervertebral disc

open access: yesJOR SPINE, Volume 8, Issue 1, March 2025.
This research unveils, for the first time, the role of ELF3 in intervertebral disc degeneration (IVDD). It sheds light on the intricate interplay between ELF3 expression and the inflammatory as well as degenerative processes inherent to IVDD. Understanding the role of ELF3 in disc pathophysiology may hold potentials in developing therapies aimed at ...
María González‐Rodríguez   +12 more
wiley   +1 more source

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