Results 31 to 40 of about 4,092 (168)

Prostaglandin endoperoxide synthase. The aspirin acetylation region.

Journal of Biological Chemistry, 1992
Aspirin selectively acetylates Ser-530 of prostaglandin endoperoxide (PGH) synthase-1. This causes inactivation of the cyclooxygenase activity of the enzyme, but does not appreciably affect its peroxidase activity. Although the aspirin-acetylated enzyme is inactive, we found that PGH synthase-1 in which Ser-530 had been replaced with an alanine was ...
T, Shimokawa, W L, Smith
openaire   +2 more sources

Characterization of the PGE2 pathway in arthritis and inflammation : mPGES-1 as a therapeutic target [PDF]

, 2013
The inducible prostaglandin (PG) E2 pathway is defined by the concerted activities of the enzymes cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase (mPGES)-1 in producing PGE2.
Leclerc, Patrick
core   +1 more source

Hematopoietic-Prostaglandin D2 synthase through PGD2 production is involved in the adult ovarian physiology [PDF]

, 2011
International audienceBackground : The prostaglandin D2 (PGD2) pathway is involved in numerous biological processes and while it hasbeen identified as a partner of the embryonic sex determining male cascade, the roles it plays in ovarian functionremain ...
Andalib Farhat, Pascal Philibert, Charles Sultan, Francis Poulat, Brigitte Boizet-Bonhoure   +4 more
core   +2 more sources

Acetylsalicylic acid interferes with embryonic kidney growth and development by a prostaglandin-independent mechanism [PDF]

, 2017
AIM: To evaluate the effects of the non-selective, non-steroidal anti-inflammatory drug (NSAID) acetylsalicylic acid (ASA), on ex vivo embryonic kidney growth and development.
Elmes, Matthew J., Gardner, David S., Sparrow, Alexander J., Welham, Simon J.M.   +3 more
core   +2 more sources

Effects of Litchi chinensis fruit isolates on prostaglandin E2 and nitric oxide production in J774 murine macrophage cells [PDF]

, 2012
Background Litchi chinensis is regarded as one of the 'heating' fruits in China, which causes serious inflammation symptoms to people.
Yang Zhou, Hong Wang, Ruili Yang, Hui Huang, Yuanming Sun, Yudong Shen, Hongtao Lei, Hong Gao   +7 more
core   +1 more source

Eicosanoids in skin inflammation. [PDF]

, 2012
NoEicosanoids play an integral part in homeostatic mechanisms related to skin health and structural integrity. They also mediate inflammatory events developed in response to environmental factors, such as exposure to ultraviolet radiation, and ...
Agarwal, Albanesi, Andersen, Andoh, Andoh, Anna Nicolaou, Baer, Baer, Baron, Bergers, Black, Boeglin, Boguniewicz, Boyce, Brash, Bray, Bryniarski, Burke, Burr, Calder, Calder, Carlson, Carsberg, Chapkin, Chen, Chene, Church, Colombe, Crespy, De Nucci, Dennis, Doepping, Du, Epp, Fincham, Fisher, Fogh, Fogh, Fogh, Ford-Hutchinson, Gledhill, Goetzl, Gonzalez, Grabbe, Grabbe, Grant, Gresham, Grundmann, Gueck, Hansen, Harris, Honda, Honda, Honma, Hruza, Ikai, Ikai, Ikai, Janssen-Timmen, Jisaka, Judson, Judson, Kanda, Keeney, Keeney, Kolgen, Konger, Kragballe, Kragballe, Krieg, Kudo, Kuhn, Ladd, Leong, Levy, Lowes, Lu, Lu, Martin, Masoodi, Massey, Matsushima, Mayer, Mayser, McCusker, McDaniel, Millard, Miller, Miller, Milne, Muller, Nakajima, Narayanan, Nichols, Nicolaou, Nicolaou, Oka, Oyoshi, Parekh, Pentland, Pietrzak, Pilkington, Proksch, Rhodes, Rhodes, Ricketts, Rijken, Ruzicka, Sato, Satoh, Schafer, Schweiger, Scott, Scott, Scott, Serhan, Serhan, Shimura, Singh, Sjursen, Spanbroek, Stark, Straus, Sugimoto, Tai, Takeda, Ueno, Watanabe, Weber, Xi, Yoo, Zheng, Zhou, Ziboh, Ziboh, Ziboh, Ziboh, Ziboh, Zulfakar, Zuo   +139 more
core   +1 more source

Regional distribution of the prostaglandin E2 receptor EP1 in the rat brain: accumulation in Purkinje cells of the cerebellum [PDF]

, 2005
Prostaglandin E2 (PGE2), is a major prostanoid produced by the activity of cyclooxygenases (COX) in response to various physiological and pathological stimuli. PGE2 exerts its effects by activating four specific E-type prostanoid receptors (EP1, EP2, EP3
Akundi, Ravi S., Candelario-Jalil, Eduardo, Fiebich, Bernd L., Hull, Michael, Ridelis, Ingrid, Slawik, Helen, Waschbisch, Anne   +6 more
core  

Involvement of PGE2 and cyclic AMP signaling pathway in the up-regulation of COX-2and mPGES-1 expression in LPS -activated macrophages [PDF]

, 2012
The final version of record is available at /http://www.biochemj.org ...
Díaz Muñoz, Manuel, Fresno, Manuel, Osma García, Inés Claire   +2 more
core   +2 more sources

mRNA expression pattern of selected candidate genes differs in bovine oviductal epithelial cells in vitro compared with the in vivo state and during cell culture passages [PDF]

, 2016
Background The mammalian oviduct provides the optimal environment for gamete maturation including sperm capacitation, fertilization, and development of the early embryo.
Einspanier, Ralf, Gabler, Christoph, Mesgaran, Sadjad Danesh, Sharbati, Jutta   +3 more
core   +1 more source

Полиморфизм гена циклооксигеназы-1 и аспиринорезистентность [PDF]

, 2012
Приведены данные литературы о структуре циклооксигеназы­1 человека – ключевого фермента биосинтеза простагландинов и основной мишени антитромбоцитарной терапии с использованием ацетилсалициловой кислоты.
Бондарь, Т.Н., Кравченко, Н.А.   +1 more
core   +2 more sources