ABSTRACT Recent studies showcased the regenerative potential of Platelet‐Rich Fibrin (PRF) combined with Adipose‐Derived Stem Cells (ASC). PRF enhances cellular proliferation through sustained growth factor secretion which are continuously released to surrounding cells. However, its regulatory mechanisms remain unclear.
Nikolaus Wachtel+7 more
wiley +1 more source
Therapeutic targeting of TGF‐β in lung cancer
Here, we discuss how lung cancer treatment can be transformed by targeting TGF‐β for better outcomes. Inhibiting TGF‐β signaling halts tumor growth, boosts immune response, and enhances treatment efficacy. By tackling TGF‐β's role in epithelial–mesenchymal transition (EMT) and immune evasion, this approach opens new avenues for more effective lung ...
Sajjad Aftabi+9 more
wiley +1 more source
Metabolism and signaling crosstalk in glioblastoma progression and therapy resistance
Glioblastoma is one of the most lethal human cancers with no effective treatment nowadays. Here, we review the increasing amount of evidence supporting the connection between cell signaling deregulation and metabolic reprogramming as a key event in glioblastoma resistance to cancer therapy.
Laura Zarzuela+2 more
wiley +1 more source
An antihypertensive lactoferrin hydrolysate inhibits angiotensin I-converting enzyme, modifies expression of hypertension-related genes and enhances nitric oxide production in cultured human endothelial cells [PDF]
This study was aimed to explore whether an antihypertensive lactoferrin hydrolysate (LFH) can inhibit angiotensin I-converting enzyme (ACE) activity and modify the expression of genes related to hypertension in human umbilical vein endothelial cells ...
Alonso, Eulalia+5 more
core +1 more source
ABSTRACT Background Chronic gut inflammation and dysbiosis contribute significantly to colorectal cancer (CRC) development. Shaoyao decoction (SYD) is a well‐established Chinese medicine prescription. Besides ameliorating CRC via anti‐inflammatory effects, SYD modulates gut microbiota (GM) to improve inflammatory responses in ulcerative colitis (UC ...
Yaojun Rong+8 more
wiley +1 more source
Characterizing the Role of Endocannabinoid Receptor Cnr1 in Mouse Ovarian Granulosa Cells
ABSTRACT The endocannabinoid receptors Cnr1 and Cnr2 have been found in reproductive organs such as the oviduct and uterus. These receptors bind to endocannabinoids, the arachinodoylethanolamine (AEA) and arachinodoylglycerol (2‐AG), respectively. Both cannbinoid receptors have been investigated for their role in implantation and fertilization. However,
Jasmine Randhawa+4 more
wiley +1 more source
Neuronal and glial prostaglandin D synthase isozymes in chick dorsal root ganglia: a light and electron microscopic immunocytochemical study. [PDF]
Homogenates of chick dorsal root ganglia (DRG) and in vitro cultures of DRG neurons are known to synthesize prostaglandin (PG) D2. To specify the PGD synthase isozymes controlling PGD2 synthesis in DRG and to identify the DRG cells responsible for this ...
Droz, B.+3 more
core +1 more source
Abstract Mounting evidence indicates the involvement of N6‐methyladenosine (m6A) alterations in diverse neurological disorders and the activation of microglia. However, the role of m6A methyltransferase Wilms' tumor 1‐associated protein (WTAP) in regulating microglial polarization during ischemic stroke (IS) remains unknown. We performed bioinformatics
Haijing Sui+3 more
wiley +1 more source
Targeting Zfp36 to combat cardiac hypertrophy: Insights into ferroptosis pathways
Zinc finger protein 36 bounds to the 3′ untranslated region of Ythdc2 mRNA, facilitating its degradation. Ythdc2 can bind to SLC7A11 mRNA to accelerate its decay, thereby reducing glutathione levels and aggravating ferroptosis‐induced cardiac hypertrophy.
Mingyu Zhang+16 more
wiley +1 more source
E74‐like ETS transcription factor 3 expression and regulation in human intervertebral disc
This research unveils, for the first time, the role of ELF3 in intervertebral disc degeneration (IVDD). It sheds light on the intricate interplay between ELF3 expression and the inflammatory as well as degenerative processes inherent to IVDD. Understanding the role of ELF3 in disc pathophysiology may hold potentials in developing therapies aimed at ...
María González‐Rodríguez+12 more
wiley +1 more source