Advanced Healthcare Materials, Volume 14, Issue 20, August 8, 2025.Engineered 3D‐Cad/IL6‐MSC, developed through synergistic hE/N‐cad‐Fc and IL‐6 preconditioning, show remarkable therapeutic potential for systemic sclerosis. These engineered MSC aggregates reduce pathogenic inflammatory cell infiltration and restore immune balance among CD4+ T‐cell populations, offering a promising approach to optimize MSC based ...
Yue Zhang +11 more
wiley +1 more source
Neural Stem Cell‐Derived Extracellular Vesicles for Advanced Neural Repair
Journal of Neurochemistry, Volume 169, Issue 8, August 2025.Neurodegenerative and neuroinflammatory diseases, such as Alzheimer's and multiple sclerosis (MS), are characterized by inflammation, nerve cell damage, and a limited capacity for natural repair, which worsens with aging. While neural stem cells (NSCs) show promise for brain repair, their clinical use is limited by safety and delivery challenges.
Eduardo H. Moretti +4 more
wiley +1 more source
Is there a role of genetics in acute and chronic urticaria—A systematic review and meta‐analysis
Clinical and Translational Allergy, Volume 15, Issue 7, July 2025.Abstract Background Chronic urticaria (CU) is a heterogeneous skin disorder whose genetic drivers are incompletely defined. Objective To systematically review and meta‐analyse genetic and epigenetic factors that influence susceptibility and treatment response in acute and CU.
George N. Konstantinou +2 more
wiley +1 more source
Ginger as a Potential Remedy for Periodontitis Treatment: A Review on the Present Evidence
Health Science Reports, Volume 8, Issue 7, July 2025.ABSTRACT Background Periodontitis is an oral inflammatory condition related to tooth‐supporting tissues (e.g., the gingiva, alveolar bone, and periodontal ligament) and affects 70%–80% of people globally. Periodontitis can be linked with some serious diseases, like cardiovascular disorders, oral cancer, and metabolic syndrome, and it has not been ...
Reza Arefnehzad +8 more
wiley +1 more source
Rapid Induction of Prostaglandin Endoperoxide Synthase in Rat Preovulatory Follicles by Luteinizing Hormone and cAMP is Blocked by Inhibitors of Transcription and Translation [PDF]
, 1989 Winona Y. L. Wong +3 more
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Human parathyroid hormone fragment stimulates the de novo synthesis of prostaglandin endoperoxide synthase in chick calvaria [PDF]
, 1993 Chin‐Yuh Yang +2 more
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Differential effects of thromboxane A2 synthase inhibition, singly or combined with thromboxane A2/prostaglandin endoperoxide receptor antagonism, on occlusive thrombosis elicited by endothelial cell injury or by deep vascular damage in canine coronary arteries. [PDF]
, 1991 G Vandeplassche +6 more
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Tyrosine 385 of prostaglandin endoperoxide synthase is required for cyclooxygenase catalysis
Journal of Biological Chemistry, 1990 There are spectral and biochemical data suggesting that a tyrosine group(s) is involved in the cyclooxygenase reaction catalyzed by prostaglandin endoperoxide (PGH) synthase. Treatment with tetranitromethane, a reagent which nitrates tyrosine residues, abolishes cyclooxygenase activity, but this inactivation can be largely prevented by competitive ...
David L. DeWitt +3 more
openaire +3 more sources
Detection of a higher oxidation state of manganese-prostaglandin endoperoxide synthase.
Journal of Biological Chemistry, 1992 Addition of arachidonic acid or 5-phenyl-4-pentenylhydroperoxide to manganese-prostaglandin endoperoxide synthase (Mn-PGH synthase) produced a species with an absorbance maximum at 418 nm. This maximum is distinct from those of resting enzyme (372 and 468 nm) or reduced enzyme (434 nm).
Krishna Rao Maddipati +2 more
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Rat Ovarian Prostaglandin Endoperoxide Synthase-1 and -2: Periovulatory Expression of Granulosa Cell-Based Interleukin-1-Dependent Enzymes [PDF]
, 1998 M. Ando
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