Results 51 to 60 of about 15,910 (222)

Fluorescent nanodiamonds for FRET-based monitoring of a single biological nanomotor FoF1-ATP synthase [PDF]

, 2009
Color centers in diamond nanocrystals are a new class of fluorescence markers that attract significant interest due to matchless brightness, photostability and biochemical inertness. Fluorescing diamond nanocrystals containing defects can be used as markers replacing conventional organic dye molecules, quantum dots or autofluorescent proteins. They can
arxiv   +1 more source

Uncovering the Effects and Molecular Mechanisms of Shaoyao Decoction Against Colorectal Cancer Using Network Pharmacology Analysis Coupled With Experimental Validation and Gut Microbiota Analysis

Cancer Medicine, Volume 14, Issue 6, March 2025.
ABSTRACT Background Chronic gut inflammation and dysbiosis contribute significantly to colorectal cancer (CRC) development. Shaoyao decoction (SYD) is a well‐established Chinese medicine prescription. Besides ameliorating CRC via anti‐inflammatory effects, SYD modulates gut microbiota (GM) to improve inflammatory responses in ulcerative colitis (UC ...
Yaojun Rong, Guiyu Zhang, Wenhao Ye, Linhua Qi, Xiaojiang Hao, Xiaolin Li, Wuhong Zhang, Yangfa Chao, Shaodong Gu   +8 more
wiley   +1 more source

Flipping the cyclooxygenase (Ptgs) genes reveals isoform-specific compensatory functions1,2[S]

Journal of Lipid Research, 2018
Two prostaglandin (PG) H synthases encoded by Ptgs genes, colloquially known as cyclooxygenase (COX)-1 and COX-2, catalyze the formation of PG endoperoxide H2, the precursor of the major prostanoids.
Xinzhi Li, Liudmila L. Mazaleuskaya, Chong Yuan, Laurel L. Ballantyne, Hu Meng, William L. Smith, Garret A. FitzGerald, Colin D. Funk   +7 more
doaj  

Monitoring transient elastic energy storage within the rotary motors of single FoF1-ATP synthase by DCO-ALEX FRET [PDF]

, 2012
The enzyme FoF1-ATP synthase provides the 'chemical energy currency' adenosine triphosphate (ATP) for living cells. Catalysis is driven by mechanochemical coupling of subunit rotation within the enzyme with conformational changes in the three ATP binding sites.
arxiv   +1 more source

Characterizing the Role of Endocannabinoid Receptor Cnr1 in Mouse Ovarian Granulosa Cells

Cell Biochemistry and Function, Volume 43, Issue 3, March 2025.
ABSTRACT The endocannabinoid receptors Cnr1 and Cnr2 have been found in reproductive organs such as the oviduct and uterus. These receptors bind to endocannabinoids, the arachinodoylethanolamine (AEA) and arachinodoylglycerol (2‐AG), respectively. Both cannbinoid receptors have been investigated for their role in implantation and fertilization. However,
Jasmine Randhawa, Ejimedo Madogwe, Aire McCall, Jaswinder Singh, Raj Duggavathi   +4 more
wiley   +1 more source

Wilms' tumor 1‐associated protein aggravates ischemic stroke by promoting M1 polarization of microglia by enhancing PTGS2 mRNA stability in an m6A‐dependent manner

Cell Biology International, Volume 49, Issue 3, Page 288-302, March 2025.
Abstract Mounting evidence indicates the involvement of N6‐methyladenosine (m6A) alterations in diverse neurological disorders and the activation of microglia. However, the role of m6A methyltransferase Wilms' tumor 1‐associated protein (WTAP) in regulating microglial polarization during ischemic stroke (IS) remains unknown. We performed bioinformatics
Haijing Sui, Chang Liu, Zhenyu Sun, Hongjie Xi   +3 more
wiley   +1 more source

Targeting Zfp36 to combat cardiac hypertrophy: Insights into ferroptosis pathways

Clinical and Translational Medicine, Volume 15, Issue 3, March 2025.
Zinc finger protein 36 bounds to the 3′ untranslated region of Ythdc2 mRNA, facilitating its degradation. Ythdc2 can bind to SLC7A11 mRNA to accelerate its decay, thereby reducing glutathione levels and aggravating ferroptosis‐induced cardiac hypertrophy.
Mingyu Zhang, Xiaoxiang Guan, Zheng Dong, Chenxu Yang, Chao Xiong, Wenzheng Cheng, Aijing Shang, Yaru Liu, Xiaofei Guo, Bowen Zhang, Bo Zhang, Saidi Jin, Wenyi Qi, Berezhnova Tatjana Alexandrovna, Yuan Jiang, Zhimin Du, Chaoqian Xu   +16 more
wiley   +1 more source

Observing single FoF1-ATP synthase at work using an improved fluorescent protein mNeonGreen as FRET donor [PDF]

, 2016
Adenosine triphosphate (ATP) is the universal chemical energy currency for cellular activities provided mainly by the membrane enzyme FoF1-ATP synthase in bacteria, chloroplasts and mitochondria. Synthesis of ATP is accompanied by subunit rotation within the enzyme.
arxiv   +1 more source

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

E74‐like ETS transcription factor 3 expression and regulation in human intervertebral disc

JOR SPINE, Volume 8, Issue 1, March 2025.
This research unveils, for the first time, the role of ELF3 in intervertebral disc degeneration (IVDD). It sheds light on the intricate interplay between ELF3 expression and the inflammatory as well as degenerative processes inherent to IVDD. Understanding the role of ELF3 in disc pathophysiology may hold potentials in developing therapies aimed at ...
María González‐Rodríguez, Djedjiga Ait Eldjoudi, Alfonso Cordero‐Barreal, Mariam Farrag, María Varela‐García, Clara Ruiz‐Fernández, Carlos Torrijos‐Pulpón, Francisca Lago, Lucía García‐Caballero, Yousof Farrag, Javier Conde‐Aranda, Jesus Pino, Oreste Gualillo   +12 more
wiley   +1 more source