Prostaglandin endoperoxide synthase. The aspirin acetylation region.
Journal of Biological Chemistry, 1992 Aspirin selectively acetylates Ser-530 of prostaglandin endoperoxide (PGH) synthase-1. This causes inactivation of the cyclooxygenase activity of the enzyme, but does not appreciably affect its peroxidase activity. Although the aspirin-acetylated enzyme is inactive, we found that PGH synthase-1 in which Ser-530 had been replaced with an alanine was ...
T, Shimokawa, W L, Smith
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Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.ABSTRACT Type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD) frequently coexist, exacerbating disease burden. However, the molecular mechanisms underlying the progression from T2DM to T2DM‐associated NAFLD remain unclear. This study investigated the regulatory function of FOS‐mediated PTGS2 activation in this transition.
Rong Lin +7 more
wiley +1 more source
Cyclooxygenase activity is important for efficient replication of mouse hepatitis virus at an early stage of infection [PDF]
, 2007 Cyclooxygenases (COXs) play a significant role in many different viral infections with respect to replication and pathogenesis. Here we investigated the role of COXs in the mouse hepatitis coronavirus (MHV) infection cycle.
Raaben, M. +10 more
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Acetylsalicylic acid interferes with embryonic kidney growth and development by a prostaglandin-independent mechanism [PDF]
, 2017 AIM: To evaluate the effects of the non-selective, non-steroidal anti-inflammatory drug (NSAID) acetylsalicylic acid (ASA), on ex vivo embryonic kidney growth and development.
Elmes, Matthew J. +3 more
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Validación de los datos obtenidos en un análisis genómico y metabolómico de un modelo animal de sobreexpresión de la COX-2 en hígado [PDF]
, 2013 Trabajo final de Master: "Aproximaciones Moleculares en ciencias de la salud": 42 p. figuras y tablas[EN] Expression of cyclooxygenase 2 (COX-2) in hepatocytes is limited to those situations where occurs dedifferentiation or proliferation as regeneration
Ovejero Martínez, Tamara
core
Selective Cyclooxygenase-2 Inhibitor Prevents Cisplatin-induced Tumorigenesis in A/J Mice [PDF]
, 2012 Cisplatin is used to treat lung cancer;however, it is also a known carcinogen. Cyclooxygenase-2 (COX-2) inhibitors have been shown to prevent carcinogen-induced experimental tumors. We investigated the effect of a COX-2 inhibitor, celecoxib, on cisplatin-
Katayama, Hideki +9 more
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Prostaglandin Endoperoxide H Synthases [PDF]
Journal of Biological Chemistry, 2007 Jiayan Liu +5 more
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Expression and Function of Prostaglandin E2 Receptors in Human Myometrium
, 2011 Preterm labour occurs in approximately 10 % of pregnancies and shows no signs of abating. Prostaglandin E2 (PGE2) synthesis plays a regulatory role in a number of important processes that are necessary for successful labour.
Kandola, Mandeep Kaur +1 more
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Comparison of PGH2 binding site in prostaglandin synthases [PDF]
, 2010 Padmapriya Paragi-Vedanthi, Mukesh Doble
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Prostaglandin Endoperoxide H Synthase-1 [PDF]
Journal of Biological Chemistry, 2001 Elizabeth D. Thuresson +9 more
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