Полиморфизм гена циклооксигеназы-1 и аспиринорезистентность [PDF]
, 2012 Приведены данные литературы о структуре циклооксигеназы1 человека – ключевого фермента биосинтеза простагландинов и основной мишени антитромбоцитарной терапии с использованием ацетилсалициловой кислоты.
Бондарь, Т.Н. +1 more
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Selective Cyclooxygenase-2 Inhibitor Prevents Cisplatin-induced Tumorigenesis in A/J Mice [PDF]
, 2012 Cisplatin is used to treat lung cancer;however, it is also a known carcinogen. Cyclooxygenase-2 (COX-2) inhibitors have been shown to prevent carcinogen-induced experimental tumors. We investigated the effect of a COX-2 inhibitor, celecoxib, on cisplatin-
Katayama, Hideki +9 more
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Indobufen versus Warfarin in the secondary prevention of major vascular events in nonrheumatic atrial fibrillation [PDF]
, 1997 ..Background and Purpose The results of a large prospective randomized trial have shown the efficacy of oral anticoagulation in the secondary prevention of major vascular events in patients with nonrheumatic atrial fibrillation (NRAF); less well ...
C. Morocutti +3 more
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Exploration of binding site pattern in arachidonic acid metabolizing enzymes, Cyclooxygenases and Lipoxygenases [PDF]
, 2015 BACKGROUND: Cyclooxygenase (COXs) and Lipoxygenase (LOXs) pathways are the two major enzymatic pathways in arachidonic acid (AA) metabolism. The term eicosanoid is used to describe biologically active lipid mediators including prostaglandins ...
Ashish Gupta +4 more
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Disruption of the prostaglandin metabolome and characterization of the pharmaceutical exposome in fish exposed to wastewater treatment works effluent as revealed by nanoflow-nanospray mass spectrometry-based metabolomics [PDF]
, 2016 Fish can be exposed to a complex mixture of chemical contaminants, including pharmaceuticals, present in discharges of wastewater treatment works (WwTWs) effluents.
Alaa Abdul-Sada +6 more
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Selective Inhibition of Vascular Endothelial Growth Factor–mediated Angiogenesis by Cyclosporin A: Roles of the Nuclear Factor of Activated T Cells and Cyclooxygenase 2 [PDF]
, 2001 Cyclosporin A (CsA) is an immunosuppressive drug that inhibits the activity of transcription factors of the nuclear factor of activated T cells (NFAT) family, interfering with the induction of cytokines and other inducible genes required for the immune ...
Fresno, Manuel +7 more
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Growth Factor Regulation of Prostaglandin-Endoperoxide Synthase 2 (Ptgs2) Expression in Colonic Mesenchymal Stem Cells [PDF]
, 2009 Monica R. Walker +4 more
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Expression and Function of Prostaglandin E2 Receptors in Human Myometrium
, 2011 Preterm labour occurs in approximately 10 % of pregnancies and shows no signs of abating. Prostaglandin E2 (PGE2) synthesis plays a regulatory role in a number of important processes that are necessary for successful labour.
Kandola, Mandeep Kaur +1 more
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Prostaglandin E2 Is a Product of Induced Prostaglandin-endoperoxide Synthase 2 and Microsomal-type Prostaglandin E Synthase at the Implantation Site of the Hamster [PDF]
, 2004 Xiaohong Wang +6 more
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