Results 61 to 70 of about 27,427 (303)

Androgenetic alopecia risk in allergic rhinitis: A cohort study of immune and antihistamine effects

World Allergy Organization Journal
Background: Androgenetic alopecia (AGA), though traditionally attributed to androgens and genetics, is increasingly linked to immune and inflammatory pathways.
Han-Wei Zhang, MD, PhD, Ya-Ting Chang, MD, PhD, Yi-Jie Kuo, MD, PhD, Yu-Pin Chen, MD, PhD, Yu-Shan Lin, BS, Fuu-Jen Tsai, PhD   +5 more
doaj   +1 more source

Ginkgolide B inhibits the neurotoxicity of prions or amyloid-β_1-42

Journal of Neuroinflammation, 2004
Background Neuronal loss in Alzheimer's or prion diseases is preceded by the accumulation of fibrillar aggregates of toxic proteins (amyloid-β1-42 or the prion protein).
Williams Alun, Salmona Mario, Bate Clive
doaj   +1 more source

Intrahypothalamic Injections of Prostaglandins and Prostaglandin Antogonists and Feeding in Sheep

Journal of Dairy Science, 1974
Abstract Prostaglandins are thought to play a role in neural transmission, and we have considered the possibility that they may act as feedbacks from fat depots to the central nervous system for maintenance of energy balance. To test for direct prostaglandin effects on the hypothalamus, sheep were implanted with guides directed toward the hypothalamus.
C A, Baile, F H, Martin, J M, Forbes, R L, Webb, W, Kingsbury   +4 more
openaire   +2 more sources

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan, Qian Zheng, Deng Liu, Ruichao Nie, Menglin Yao, Xiaolong Tang, Renjie Xu, Jinghong Xian, Wenjun Meng, Wenxin Luo, Dan Liu, Guiyi Ji   +11 more
wiley   +1 more source

Synthesis and Biological Activity of Various Derivatives of a Novel Class of Potent, Selective, and Orally Active Prostaglandin D₂ Receptor Antagonists. 2. 6,6-Dimethylbicyclo[3.1.1]heptane Derivatives [PDF]

, 2016
In an earlier paper, we reported that novel prostaglandin D2 (PGD2) receptor antagonists having the bicyclo[2.2.1]heptane ring system as a prostaglandin skeleton were a potent new class of antiallergic agents and suppressed various allergic inflammatory ...
Tatsuo Tsuri (3015510), Shiro Kida (3015513), Susumu Mitsumori (2336905), Tsunetoshi Honma (2336902), Yoshiharu Hiramatsu (2336911), Fujio Asanuma (3015498), Junji Kishino (354556), Hiroshi Hashizume (188480), Mitsuaki Ohtani (3015495), Toshihiko Okada (548701), Akinori Arimura (3015507), Kiyoshi Yasui (3015504), Masanao Inagaki (3015501)   +12 more
core   +1 more source

Ginkgolides protect against amyloid-β_1–42-mediated synapse damage in vitro

Molecular Neurodegeneration, 2008
Background The early stages of Alzheimer's disease (AD) are closely associated with the production of the Aβ1–42 peptide, loss of synapses and gradual cognitive decline.
Williams Alun, Tayebi Mourad, Bate Clive
doaj   +1 more source

T2T Genome Assembly and Multi‐Omics Data Reveal Terrestrial Adaptation and Mucus Biosynthesis in Tropical Leatherleaf Slug (Laevicaulis alte)

Advanced Science, EarlyView.
A gap‐free genome assembly and multi‐omics comparison of the terrestrial slug Laevichaulis alte with an aquatic relative reveal that expansion of the VEGF family orchestrates mucus production, lipid metabolism, and immune defense—highlighting key molecular innovations for conquering life on land.
Gang Wang, Shaofang He, Zhongkai Wang, Aobo Pang, Xiaoli Sun, Rongchen Liu, Fang Wang, Sisi Chen, Zhijuan Bian, Dongcheng Wei, Liuhan Wu, Siyao Zhao, Qiuting Ji, Yiqi Sun, Niying Sun, Yushinta Fujaya, Boping Tang, Kianann Tan, Daizhen Zhang, Lianfu Chen   +19 more
wiley   +1 more source

Prostaglandin E Receptor 4 Antagonist in Cancer Immunotherapy: Mechanisms of Action

Frontiers in Immunology, 2020
A highly expressed prostaglandin E2 (PGE2) in tumor tissues suppresses antitumor immunity in the tumor microenvironment (TME) and causes tumor immune evasion leading to disease progression.
Yukinori Take, Shinichi Koizumi, Atsushi Nagahisa, Atsushi Nagahisa   +3 more
doaj   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Chemokine-induced secretion of gelatinase B in primary human monocytes [PDF]

, 2001
Chemokines help control normal leukocyte trafficking as well as their infiltration into tissues during acute and chronic inflammation. Matrix metalloproteinases (MMPs) help support the extravasation and infiltration of leukocytes through limited ...
Nelson, EL, Nelson, P. J., Schlöndorff, D, C.D. Cohen, D. Schlöndorff, C.M. Klier, Horuk, R, P.J. Nelson, Schlöndorff, D., Klier, C. M., E.L. Nelson, Nelson, PJ, Cohen, CD, Horuk, R., Cohen, C. D., R. Horuk, Klier, CM, Nelson, E. L.   +17 more
core   +1 more source