Results 81 to 90 of about 27,427 (303)

Exacerbation of Intracranial Aneurysm and Aortic Dissection in Hypertensive Rat Treated With the Prostaglandin F–Receptor Antagonist AS604872

Journal of Pharmacological Sciences, 2014
.: Intracranial aneurysm (IA) and aortic dissection are both complications of hypertension and characterized by degeneration of the media. Given the involvement of prostaglandin F2α and its receptor, FP, in extracellular matrix remodeling in a mouse ...
Miyuki Fukuda, Tomohiro Aoki, Toshiaki Manabe, Akiko Maekawa, Takayuki Shirakawa, Hiroharu Kataoka, Yasushi Takagi, Susumu Miyamoto, Shuh Narumiya   +8 more
doaj   +1 more source

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source

IRF‐1 modulates hepatic ferroptosis and aggravates liver ischemia/reperfusion injury via DYRK1α

Animal Models and Experimental Medicine, EarlyView.
IRF‐1 modulates hepatic ferroptosis and aggravates liver ischemia/reperfusion injury via DYRK1α. Abstract Background The purpose is to define the contribution of the interferon regulatory factor‐1–dual‐specificity tyrosine phosphorylation‐regulated kinase 1α (IRF‐1–DYRK1α) axis to hepatocellular ferroptosis during liver ischemia/reperfusion injury ...
Jinping Zhang, Jinming Zhang, Siyuan Song, Mingyang Li, Liying Sun, Zhijun Zhu, Dongdong Lin   +6 more
wiley   +1 more source

Prostanoid receptor antagonists: development strategies and therapeutic applications [PDF]

, 2009
Identification of the primary products of cyclo-oxygenase (COX)/prostaglandin synthase(s), which occurred between 1958 and 1976, was followed by a classification system for prostanoid receptors (DP, EP1, EP2 …) based mainly on the pharmacological actions
MA Giembycz, Jones, R.L., Woodward, D.F., DF Woodward, RL Jones, Giembycz, M.A.   +5 more
core   +1 more source

Anti-Inflammatory Effects by Pharmacological Inhibition or Knockdown of Fatty Acid Amide Hydrolase in BV2 Microglial Cells

Cells, 2019
Fatty acid amide hydrolase (FAAH) has been recognized as a therapeutic target for several neurological diseases because its inhibition can exert neuroprotective and anti-inflammatory effects by boosting the endogenous levels of N-acylethanolamines ...
Mikiei Tanaka, Kazuya Yagyu, Scott Sackett, Yumin Zhang   +3 more
doaj   +1 more source

Enhancing Meat Quality Through Dietary Fiber: Insights Into the Gut Microbiota‐Derived Short‐Chain Fatty Acids‐Muscle Axis

Animal Research and One Health, EarlyView.
Dietary fiber (DF) modulates meat quality through the gut‐muscle axis by reshaping gut microbiota, improving intestinal integrity, reducing inflammation, and regulating muscle metabolism. These mechanisms influence muscle fiber characteristics and post‐mortem biochemistry, thereby enhancing tenderness, juiciness, color, flavor, and nutritional value of
Zeshan Zulfiqar, Muhammad Arslan Asif, Layla Al‐Mitib, Nabeela Ashiq, Haojie Wang, Yalei Cui, Boshuai Liu, Shucheng Huang, Yinghua Shi   +8 more
wiley   +1 more source

Caracterização farmacológica e molecular dos mecanismos envolvidos no edema de pata induzido pela prostaglandina E2 (PGE2) [PDF]

, 2006
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas.
Claudino, Rafaela Franco
core  

Prostaglandin receptors mediate effects of substances released from ischaemic rat hearts on non-ischaemic cardiomyocytes [PDF]

, 2008
Background: After ischaemia and during reperfusion, rat hearts release cardiodepressive substances that are putatively cyclooxygenase-2-dependent. The present study analyses the mechanisms by which these substances mediate their effect downstream of ...
Felix, S.B., Landsberger, M., Schunck, W.H., Trimpert, C., Völker, U., Schunck, W. H., Krieg, T., Birkenmeier, K., Janke, I., Felix, S. B., Staudt, A., Voelker, U.   +11 more
core   +1 more source

Effect of prostaglandin D2 on VEGF release by nasal polyp fibroblasts

Allergology International, 2016
Background: Vascular endothelial growth factor (VEGF) is known to be associated with the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP). VEGF is produced by a variety of cells including fibroblasts.
Kengo Kanai, Mitsuhiro Okano, Tazuko Fujiwara, Shin Kariya, Takenori Haruna, Ryotaro Omichi, Sei-ichiro Makihara, Yuji Hirata, Kazunori Nishizaki   +8 more
doaj   +1 more source

Photobiomodulation Enhances Tendon Regeneration: A Systematic Review and Meta‐analysis of Preclinical Studies

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To evaluate the preclinical evidence supporting the efficacy of photobiomodulation therapies in tendon regeneration. Methods A comprehensive literature search was conducted in MEDLINE, ScienceDirect, and Google Scholar to identify in vivo animal studies evaluating photobiomodulation therapies for tendon healing.
Yose Waluyo, Diah Nurul Islami Muchsin, Muthiah Nur Afifah, Yaldi Rosadi, M. Salas Al Aldi   +4 more
wiley   +1 more source