Results 161 to 170 of about 346,955 (321)

Developmental pharmacokinetics of indomethacin in preterm neonates: Severely decreased drug clearance in the first week of life

CPT: Pharmacometrics &Systems Pharmacology, Volume 12, Issue 1, Page 110-121, January 2023., 2023
Abstract Indomethacin is used commonly in preterm neonates for the prevention of intracranial hemorrhage and closure of an abnormally open cardiac vessel. Due to biomedical advances, the infants who receive this drug in the neonatal intensive care unit setting have become younger, smaller, and less mature (more preterm) at the time of treatment.
Wojciech Krzyzanski, Bradley Stockard, Andrea Gaedigk, Allison Scott, Whitney Nolte, Kim Gibson, J. Steven Leeder, Tamorah Lewis   +7 more
wiley   +1 more source

Effect of fatty acid modification on prostaglandin production by cultured 3T3 cells.

Journal of Lipid Research, 1982
We have investigated the extent to which modifications in the essential fatty acid content of mammalian cells can affect prostaglandin production.
G M Denning, P H Figard, A A Spector
doaj  

The microsomal prostaglandin E synthase-1/prostaglandin E2 axis induces recovery from ischaemia via recruitment of regulatory T cells. [PDF]

Cardiovasc Res, 2023
Amano H, Eshima K, Ito Y, Nakamura M, Kitasato H, Ogawa F, Hosono K, Iwabuchi K, Uematsu S, Akira S, Narumiya S, Majima M.   +11 more
europepmc   +1 more source

Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches

Epilepsia Open, EarlyView.
Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza, Greta Volpedo, Antonella Riva, Pasquale Striano, Annamaria Vezzani   +4 more
wiley   +1 more source

Dihydroartemisinin inhibits melanoma migration and metastasis by affecting angiogenesis

Phytotherapy Research, EarlyView., 2023
Abstract Tumor angiogenesis is critical for tumor metastasis by providing oxygen, nutrients, and metastatic pathways. As a potential anti‐angiogenic agent, Dihydroartemisinin (DHA) can effectively inhibit tumor metastasis. However, the mechanism how it regulates angiogenesis to affect tumor metastasis has not been fully clarified.
Zhaoxiang Li, Qi Zhang, Xinyuan Zhang, Quanxin Jin, Qi Yue, Na Li, Huan Liu, Manabu Fujimoto, Guihua Jin   +8 more
wiley   +1 more source

Harnessing prostaglandin E₂ signaling to ameliorate autoimmunity. [PDF]

Trends Immunol, 2023
Burkett JB, Doran AC, Gannon M.
europepmc   +1 more source

Drug delivery pathways to the central nervous system via the brain glymphatic system circumventing the blood‐brain barrier

Exploration, EarlyView.
The discovery of the glymphatic system has opened up a pathway for drug delivery to the brain by circumventing the blood‐brain barrier, which can effectively improve drug utilization. The methods of drug delivery through the glymphatic system include intrathecal injection, intranasal injection, and delivery through the meningeal lymphatic vessels.
Xiang Wang, Yue Yin, Huaijuan Zhou, Bowen Chi, Ling Guan, Pei Li, Jinhua Li, Yilong Wang   +7 more
wiley   +1 more source

E-type prostaglandins: a new emergency therapy for certain cyanotic congenital heart malformations. [PDF]

, 1976
Peter M. Olley, Flavio Coceani, E. Bodach   +2 more
openalex   +1 more source

Surface‐Anchored Ticagrelor Gelatin Nanoparticles‐Platelets System for Enhanced Anti‐PD‐L1 Therapy Response and Boosted Chemotherapeutic Efficacy of Nanomedicines

Exploration, EarlyView.
Ticagrelor nanoparticles modified platelets could adhere to tumor‐associated platelets by specific recruiting ability and responsively release ticagrelor under MMPs stimulation. The released ticagrelor could inhibit platelets activity, enhancing tumor treatment efficacy.
Qi Lu, Hao Ye, Jian Zhao, Xiaoyuan Fan, Kaiyuan Wang, Zeyu Han, Tian Liu, Lili Du, Jiaxuan Song, Helin Wang, Haotian Zhang, Zhonggui He, Jin Sun   +12 more
wiley   +1 more source

Inducible Prostaglandin E Synthase as a Pharmacological Target for Ischemic Stroke. [PDF]

Neurotherapeutics, 2022
Li L, Yasmen N, Hou R, Yang S, Lee JY, Hao J, Yu Y, Jiang J.   +7 more
europepmc   +1 more source