Results 281 to 290 of about 346,955 (321)

The anion exchanger slc26a3 regulates colonic mucus expansion during steady state and in response to prostaglandin E₂, while Cftr regulates de novo mucus release in response to carbamylcholine. [PDF]

Pflugers Arch
Ljungholm PL, Ermund A, Söderlund Garsveden MM, Pettersson VL, Gustafsson JK.   +4 more
europepmc   +1 more source

Negative Effect of Gst‐35 on the Health Span of Caenorhabditis elegans Through Lysosomal Dysfunction via the Pmk‐1 and Skr Genes

Aging Cell, EarlyView.
The overexpression of gst‐35, the mammalian orthologous genes GSTA1, GSTA2, and GSTA3, induces lysosomal dysfunction through the genes pmk‐1 and skr in C. elegans. This overexpression not only promotes an in vivo inflammatory response and accumulation of reactive oxygen species but also significantly shortens the nematode lifespan; inhibits its ...
Yehui Gao, Xinyun Zhang, Congmin Wei, Hongru Lin, Mengchen Wu, Botian Ma, Jinyun Jiang, Shan Li, Hongbing Wang   +8 more
wiley   +1 more source

The effect of aspirin and eicosapentaenoic acid on urinary biomarkers of prostaglandin E₂ synthesis and platelet activation in participants of the seAFOod polyp prevention trial. [PDF]

Int J Cancer
Sun G, Fuller H, Fenton H, Race AD, Downing A, Williams EA, Rees CJ, Brown LC, Loadman PM, Hull MA.   +9 more
europepmc   +1 more source

19-HydroxyIated E prostaglandins as the major prostaglandins of human semen [PDF]

Nature, 1974
ALMOST 30 years after the initial discovery of the prostaglandins, Bergstrom et al., succeeded in isolating and identifying prostaglandins (PGs) E1, E2, F1α and F2α from sources including human semen1. It was subsequently claimed2 that the 19-hydroxy derivatives of prostaglandins A and B were also present. These compounds were later found at an average
P. L. Taylor, R. W. Kelly
openaire   +2 more sources

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Specific reduction of E prostaglandins to F.alpha. prostaglandins and prostaglandin E2 to prostaglandin E1

Journal of the American Chemical Society, 1971
This is an explanation of 2 highly specific reductive processes for the interconversion of primary PGs (prostaglandins). The laboratory procedures are described in detail and the chemical structures of substances involved in the process are diagrammed. A stereospecific reduction of PGE to PGFalpha is described.
E. J. Corey, Ravi K. Varma
openaire   +3 more sources

Stability of prostaglandin E compounds in solution [PDF]

Lipids, 1973
AbstractIn the present paper the stability of prostaglandins E1, E2, and E3has been studied in two types of solvents: (a) solvents in which they can be used in clinical trials and (b) solvents which are commonly used for their isolation from biological systems.
K. C. Srivastava, J. Clausen
openaire   +2 more sources

Prostaglandin E synthase

Prostaglandins & Other Lipid Mediators, 2002
Prostaglandin E synthase (PGES), which converts cyclooxygenase (COX)-derived prostaglandin (PG)H2 to PGE2, occurs in multiple forms with distinct enzymatic properties, modes of expression, cellular and subcellular localizations and intracellular functions.
Yoshihito Nakatani, Toshihiro Tanioka, Makoto Murakami, Ichiro Kudo   +3 more
openaire   +2 more sources

Prostaglandin E receptors and the kidney

American Journal of Physiology-Renal Physiology, 2000
Prostaglandin E2is a major renal cyclooxygenase metabolite of arachidonate and interacts with four G protein-coupled E-prostanoid receptors designated EP1, EP2, EP3, and EP4. Through these receptors, PGE2modulates renal hemodynamics and salt and water excretion. The intrarenal distribution and function of EP receptors have been partially characterized,
Matthew D. Breyer, Richard M. Breyer
openaire   +3 more sources

Antidipsogenic role of the E-prostaglandins.

Journal of Comparative and Physiological Psychology, 1978
Prostaglandin E1 (PGE1) is antidipsogenic when administered into the lateral cerebral ventricle of the rat. In these experiments PGE1, at a dose of 1 microgram, suppressed water intake induced by centrally administered angiotensin II (AII) or carbachol, subcutaneously administered polyethylene glycol, and water deprivation. Even at this high dose, PGE1
Alan N. Epstein, Nancy J. Kenney
openaire   +3 more sources

Prostaglandin E2-induced inflammation: Relevance of prostaglandin E receptors

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2015
Prostaglandin E2 (PGE2) is one of the most typical lipid mediators produced from arachidonic acid (AA) by cyclooxygenase (COX) as the rate-limiting enzyme, and acts on four kinds of receptor subtypes (EP1-EP4) to elicit its diverse actions including pyrexia, pain sensation, and inflammation.
Kohichi Kawahara, Tomoaki Inazumi, Yukihiko Sugimoto, Soken Tsuchiya, Hirofumi Hohjoh   +4 more
openaire   +3 more sources