Results 291 to 300 of about 346,955 (321)

Role of seminal prostaglandins in male fertility. I. Relationship of prostaglandin E and 19-OH prostaglandin E with seminal parameters

Journal of Endocrinological Investigation, 1980
Prostaglandin (PG) E and 19-OH PGE, now considered to be the most important of the human seminal prostaglandins, were assayed in infertile and normal men. In the 15 volunteers PGE and 19-OH PGE levels were 23-89 microgram/ml, respectively. In the 4 groups of infertile patients in whom either PGE or 19-OH PGE levels were increased or decreased with ...
A. Isidori, D Conte, G. Laguzzi, P. Giovenco, F. Dondero   +4 more
openaire   +3 more sources

Prostaglandin E and cancer Growth

Cancer Immunology, Immunotherapy, 1980
This paper reviews the evidence linking prostaglandin E (PGE) with the growth of neoplastic tissue. PGE 2 is present in high concentrations in many natural and experimentally produced cancers. The immunosuppressive effect of some tumors in mice is due at least in part to a prostaglandin mechanism.
Ralph C. Williams, James S. Goodwin, G. Husby   +2 more
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ChemInform Abstract: STEREOSELECTIVE REDUCTION OF PROSTAGLANDINS E TO PROSTAGLANDINS F

Chemischer Informationsdienst, 1980
AbstractDie Prostaglandine E (I) gehen bei der Reduktion mit Li in Tetrahydrofuran und flüssigem Ammoniak in die Prostaglandine Fß(II) über.
K. K. Pivnitskii, V. I. Mel'nikova
openaire   +2 more sources

Difference in Haemodynamic Response to Prostaglandins A and E

Nature, 1971
PROSTAGLANDINS A and E are vasodepressor substances, the effect of which has been attributed to direct vasodilator action on peripheral arteriolar smooth muscle1–7. The mechanism of the hypotensive effect of the two prostaglandins may not, however, be identical.
Hartmut Kannegiesser, James B. Lee
openaire   +3 more sources

Prostaglandin E in peptic ulcer disease

Prostaglandins, 1974
Abstract Prostaglandin E 1 and E 2 inhibit gastric secretion in vivo and in vitro under a variety of conditions. It is not known whether these compounds may play a role in normal gastric secretory physiology or in the pathophysiology of peptic ulcer disease.
Juan J. Engel, James G. Hinsdale, Donald E. Wilson   +2 more
openaire   +3 more sources

Stability of E-Type Prostaglandins in Triacetin

Journal of Pharmaceutical Sciences, 1979
A drug delivery system for E-type prostaglandins is described. In this system, consisting of drug dissolved in triacetin and filled into soft gelatin capsules, normally unstable prostaglandins show excellent stability at room temperature.
T.J. Roseman, Samuel H. Yalkowsky
openaire   +3 more sources

The immunomodulatory actions of E-type prostaglandins

Expert Opinion on Investigational Drugs, 1997
Prostaglandins (PGs) have been recognised as modulators of immune responses. This has been proved by both in vitro studies and from observations in animals and humans. Administration of prostaglandins for therapeutic purposes, however, has been hampered by their limited bioavailability and their pleiotropic effects, with resultant toxicological profile.
J Rhodes, GW De Vries, A McLaughlin
openaire   +3 more sources

Depression, immunocompetence, and prostaglandins of the E series

Psychiatry Research, 1986
Plasma prostaglandin E1 and E2, and quantitative and qualitative measures of immune function, were determined in depressed patients and healthy controls. Prostaglandin E2 was significantly elevated in the depressed group, and prostaglandin E1 showed a trend in the same direction.
Neal E. Krupp, Rafael Valenzuela, Robert G. Skwerer, Joseph R. Calabrese, A. Dale Gulledge, Antanas Butkus, Steven Subichin, Barbara P. Barna   +7 more
openaire   +3 more sources

Prostaglandin E synthase in the pathophysiology of arthritis

Fundamental & Clinical Pharmacology, 2005
AbstractProstaglandin E synthase (PGES) is a recently identified terminal enzyme that acts downstream of cyclooxygenase and catalyzes the conversion of prostaglandin (PG) H2 to PGE2. At least three isozymes have been cloned so far, which are called membrane‐associated PGES (mPGES)‐1, mPGES‐2, and cytosolic PGES.
Shinichi Kawai, Shinichi Kawai, Soichiro Kato, Fumiaki Kojima   +3 more
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Measurement of prostaglandin E in crevicular fluid

Journal of Clinical Periodontology, 1981
Abstract A method for the detection of prostaglandin E (PGE) in crevicular fluid has been developed which provides a sensitive, noninvasive technique for measurement of local concentrations of this mediator of inflammation. Assay sensitivity sufficient for the detection of 4 picograms of PGE2; was achieved by utilizing a high‐affinity anti‐PGE2 ...
J. M. Goodson, D. H. Farr, S. Offenbacher   +2 more
openaire   +3 more sources