Results 311 to 320 of about 236,875 (335)

The immunomodulatory actions of E-type prostaglandins

Expert Opinion on Investigational Drugs, 1997
Prostaglandins (PGs) have been recognised as modulators of immune responses. This has been proved by both in vitro studies and from observations in animals and humans. Administration of prostaglandins for therapeutic purposes, however, has been hampered by their limited bioavailability and their pleiotropic effects, with resultant toxicological profile.
J Rhodes, GW De Vries, A McLaughlin
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Prostaglandin E synthase in the pathophysiology of arthritis

Fundamental & Clinical Pharmacology, 2005
AbstractProstaglandin E synthase (PGES) is a recently identified terminal enzyme that acts downstream of cyclooxygenase and catalyzes the conversion of prostaglandin (PG) H2 to PGE2. At least three isozymes have been cloned so far, which are called membrane‐associated PGES (mPGES)‐1, mPGES‐2, and cytosolic PGES.
Shinichi Kawai, Shinichi Kawai, Soichiro Kato, Fumiaki Kojima   +3 more
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Depression, immunocompetence, and prostaglandins of the E series

Psychiatry Research, 1986
Plasma prostaglandin E1 and E2, and quantitative and qualitative measures of immune function, were determined in depressed patients and healthy controls. Prostaglandin E2 was significantly elevated in the depressed group, and prostaglandin E1 showed a trend in the same direction.
Neal E. Krupp, Rafael Valenzuela, Robert G. Skwerer, Joseph R. Calabrese, A. Dale Gulledge, Antanas Butkus, Steven Subichin, Barbara P. Barna   +7 more
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Measurement of prostaglandin E in crevicular fluid

Journal of Clinical Periodontology, 1981
Abstract A method for the detection of prostaglandin E (PGE) in crevicular fluid has been developed which provides a sensitive, noninvasive technique for measurement of local concentrations of this mediator of inflammation. Assay sensitivity sufficient for the detection of 4 picograms of PGE2; was achieved by utilizing a high‐affinity anti‐PGE2 ...
J. M. Goodson, D. H. Farr, S. Offenbacher   +2 more
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The content of prostaglandin E and prostaglandin F2α in the exudate of carrageenin granuloma of rats

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1976
1. Granuloma was made by the subcutaneous injection of 2% carrageenin solution on the dorsum of male rats. Eight, 16, 24 and 72 h after the injection. the exudate from each rat granuloma was withdrawn and extracted for rpstaglandins. 2. Extracted prostaglandins were separated prostaglandin E and prostaglandin F group by silicic acid mini-column ...
Hiroshi Sato, Kazuo Ohuchi, Susumu Tsurufuji   +2 more
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The glutathione conjugate of prostaglandin a, is a better substrate than prostaglandin E for partially purified avian prostaglandin E 9-ketoreductase

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1979
Abstract The reduction of the glutathione conjugate of prostaglandin A1 by avian prostaglandin E 9-ketoreductase occurs at a faster rate than reduction of its presumed natural substrates, prostaglandin E1 or E2.
Lauren M. Cagen, John J. Pisano
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Two Types of Microsomal Prostaglandin E Synthase: Glutathione-Dependent and -Independent Prostaglandin E Synthases

Biochemical and Biophysical Research Communications, 1997
Prostaglandin (PG) E synthase was found to be widely distributed in the microsomal fractions of rat organs. Among them, an extremely high activity was seen in the deferent duct (112 nmol/min x mg) and other genital accessory organs (10-20 nmol/min x mg). In non-genital organs, the kidney had the highest activity (8 nmol/min x mg).
Osamu Hayaishi, Kikuko Watanabe, Kayoko Kurihara, Yoshimitsu Tokunaga   +3 more
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Augmentation of Functional Prostaglandin E Levels on the Respiratory Epithelial Surface by Aerosol Administration of Prostaglandin E

American Review of Respiratory Disease, 1991
Prostaglandin E (PGE), a cyclooxygenase metabolite normally present in high concentrations in respiratory epithelial lining fluid (ELF), is capable of suppressing mesenchymal cell proliferation mediated by polypeptide-derived growth factors. Although PGE is normally abundant in respiratory ELF, PGE levels in ELF of individuals with idiopathic pulmonary
Toshio Ozaki, Stephen I. Rennard, Zea Borok, Adrian Gillissen, R C Hubbard, Roland Buhl, Ronald G. Crystal, Robert F. Hoyt   +7 more
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Pharmacocavernometry with Prostaglandin E(1)

European Urology, 1993
The aim of this study was to define the normal response of cavernometry parameters with high-dose pharmacostimulation, to investigate repeatability of the method and to find out the incidence of cavernovenous leakage in impotence. 82 consecutive impotent patients and 10 potent control subjects underwent pharmacocavernometry with 40 micrograms of ...
Nisén Ho, Ruutu Ml
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ChemInform Abstract: TOTAL SYNTHESIS OF PROSTAGLANDINS PART 7, ASYMMETRIC TOTAL SYNTHESIS OF (‐)‐PROSTAGLANDIN E(1) AND (‐)‐PROSTAGLANDIN E(2)

Chemischer Informationsdienst, 1975
AbstractMikrobiologische asymm. Reduktion der Triketone (I) mit Dipodascus uninucleatus liefert die (4R)‐Alkohole (II).
Sang Sook Lee, Rattan S. Sood, J. B. Heather, L. F. Hsu Lee, George Peruzzotti, Charles J. Sih, Philip Price   +6 more
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