Results 1 to 10 of about 394,079 (375)
Imbalance of endogenous prostanoids in moderate-to-severe asthma
Allergology International, 2017 Background: Inhalation studies suggested “protective” roles of exogenous prostaglandin E2, but the clinical relevance of endogenous prostanoids in asthma is poorly known. The objective of this study is to measure sputum levels of prostanoids in asthmatic
Masaya Takemura +8 more
doaj +2 more sources
Definitions, 2020 A prostaglandin with 2 double bonds that is generated by the action of prostaglandin E synthases on prostaglandin H2. Prostaglandin E2 is a mediator of active inflammation, and has important biologic effects including potent vasodilation, smooth muscle ...
openaire +2 more sources
Prostaglandin E2, an Immunoactivator
Journal of Pharmacological Sciences, 2010 Diseases caused by immune inflammation, such as rheumatoid arthritis, multiple sclerosis, and Crohn’s disease, are intractable diseases to which novel therapeutics are highly demanded.
Daiji Sakata +2 more
doaj +4 more sources
Prostaglandin E2 promotes features of replicative senescence in chronically activated human CD8+ T cells. [PDF]
, 2014 Prostaglandin E2 (PGE2), a pleiotropic immunomodulatory molecule, and its free radical catalyzed isoform, iso-PGE2, are frequently elevated in the context of cancer and chronic infection.
Chou, Jennifer P +4 more
core +13 more sources
Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium [PDF]
EMBO Journal, 2017 Adaptive cellular responses are often required during wound repair. Following disruption of the intestinal epithelium, wound‐associated epithelial (WAE) cells form the initial barrier over the wound.
Lai, Chin-Wen +7 more
core +3 more sources
Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts. [PDF]
Journal of Experimental Medicine, 1985 Cachectin/TNF (tumor necrosis factor), an endotoxin-induced murine macrophage hormone implicated in the pathogenesis of cachexia and shock, has been found capable of stimulating collagenase and prostaglandin E2 (PGE2) production by isolated human ...
Jean‐Michel Dayer +2 more
openalex +2 more sources
Prostaglandin E2 and the EP receptors in malignancy: possible therapeutic targets? [PDF]
British Journal of Pharmacology, 2015 Grace O’Callaghan, Aileen Houston
openalex +2 more sources
Frontiers in Physiology, 2022 Rotaviruses are one of the leading causes of severe dehydrating diarrhoea in infants and children under the age of five. Despite the introduction of vaccines, disease burden remains high in sub-Saharan Africa, with no known anti-viral treatments ...
Willem J. Sander +4 more
doaj +1 more source
Cyclooxygenase-2-Prostaglandin E2 pathway: A key player in tumor-associated immune cells
Frontiers in Oncology, 2023 Cyclooxygenases-2 (COX-2) and Prostaglandin E2 (PGE2), which are important in chronic inflammatory diseases, can increase tumor incidence and promote tumor growth and metastasis.
Kai-Yan Jin +3 more
semanticscholar +1 more source
Role of prostaglandin E2 in tissue repair and regeneration
Theranostics, 2021 Tissue regeneration following injury from disease or medical treatment still represents a challenge in regeneration medicine. Prostaglandin E2 (PGE2), which involves diverse physiological processes via E-type prostanoid (EP) receptor family, favors the ...
Hui Cheng +4 more
semanticscholar +1 more source