Hepatology, EarlyView., 2022 Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario +12 more
wiley +1 more source
Improved homology modeling of the human & rat EP4 prostanoid receptors
BMC Molecular and Cell Biology, 2019 Background The EP4 prostanoid receptor is one of four GPCRs that mediate the diverse actions of prostaglandin E2 (PGE2). Novel selective EP4 receptor agonists would assist to further elucidate receptor sub-type function and promote development of ...
Melissa C. Holt +4 more
doaj +1 more source
Prostaglandin E2 in apical tissue fluid and postoperative pain in intact and teeth with large restorations in two endodontic treatment visits [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2013 Introduction. Acute periapical inflammation is the most common cause of postoperative pain developing as a result of mechanical, chemical and/or microbial injury of periapical tissue.
Grga Đurica +3 more
doaj +1 more source
Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production. [PDF]
, 2006 Inhibition of neuronal cyclooxygenase-2 (COX-2) and hence prostaglandin E2 (PGE2) synthesis by non-steroidal anti-inflammatory drugs has been suggested to protect neuronal cells in a variety of pathophysiological situations including Alzheimer's disease ...
Akundi, Ravi S. +7 more
core +1 more source
Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis
Nature Communications, 2019 Whether sensory nerve can sense bone density or metabolic activity to control bone homeostasis is unknown. Here we found prostaglandin E2 (PGE2) secreted by osteoblastic cells activates PGE2 receptor 4 (EP4) in sensory nerves to regulate bone formation ...
Hao Chen +21 more
semanticscholar +1 more source
Molecular mechanisms underlying prostaglandin E2-exacerbated inflammation and immune diseases.
International Immunology, 2019 Prostaglandins (PGs) are the major lipid mediators in animals and which are biosynthesized from arachidonic acid by the cyclooxygenases (COX-1 or COX-2) as the rate-limiting enzymes.
Kyoshiro Tsuge +3 more
semanticscholar +1 more source
Mediators of Inflammation, 1998 Lipopolysaccharide is an inflammatory agent and interleukin-1 is a cytokine. Their pro-inflammatory effects may be mediated by prostanoids produced by inducible cyclooxygenase-2.
W. E. Longo +5 more
doaj +1 more source
Polyunsaturated fatty acid-derived lipid mediators and T cell function [PDF]
, 2014 Copyright © 2014 Nicolaou, Mauro, Urquhart and Marelli-Berg . This is an open- access article distributed under the terms of the Creative Commons Attribution License (CC BY) .
Marelli-Berg, F +3 more
core +3 more sources
Prostaglandin E2/EP Signaling in the Tumor Microenvironment of Colorectal Cancer
International Journal of Molecular Sciences, 2019 The number of colorectal cancer (CRC) patients is increasing worldwide. Accumulating evidence has shown that the tumor microenvironment (TME), including macrophages, neutrophils, and fibroblasts, plays an important role in the development and progression
Rei Mizuno, K. Kawada, Y. Sakai
semanticscholar +1 more source
Evidence that the E2-isoprostane, 15-E2t-isoprostane (8-iso-prostaglandin E2) is formed in vivo
Journal of Lipid Research, 1998 D2/E2-isoprostanes are prostaglandin D2/E2-like compounds that are produced in vivo as non-enzymatic products of free radical catalyzed peroxidation of arachidonic acid.
Jason D. Morrow +4 more
doaj +1 more source