Results 61 to 70 of about 373,954 (298)
Journal of Dairy Science, 2022 : Prostaglandins are involved in multiple processes important for fertility, with previous work in mice highlighting a potential role for the HSD17B12 gene in prostaglandin biosynthesis.
J.L. Juengel +7 more
doaj
Scientific Reports, 2021 Mesenchymal stem cells (MSCs) administered for therapeutic purposes can be activated by interferon-γ (IFN-γ) secreted from natural killer cells in injured tissues and exert anti-inflammatory effects.
Ryo Kanai +11 more
doaj +1 more source
‘Antiflammins’: Two nonapeptide fragments of uteroglobin and lipocortin I have no phospholipase A2 -inhibitory and anti-inflammatory activity [PDF]
, 1990 The ‘antiflammin’ nonapeptides P1 and P2 [(1988) Nature 335, 726-730] were synthesized and tested for inhibition of phospholipase A2 and release of prostaglandin E2, and leukotriene C4 in stimulated cells in vitro, and in vivo for anti-inflammatory ...
Marki, F. +3 more
core +1 more source
Novel contraceptive targets to inhibit ovulation: the prostaglandin E2 pathway.
Human Reproduction Update, 2015 BACKGROUND Prostaglandin E2 (PGE2) is an essential intrafollicular regulator of ovulation. In contrast with the one-gene, one-protein concept for synthesis of peptide signaling molecules, production and metabolism of bioactive PGE2 requires controlled ...
D. Duffy
semanticscholar +1 more source
Reversal of the Transcriptome by Prostaglandin E2 during Myofibroblast Dedifferentiation.
American Journal of Respiratory Cell and Molecular Biology, 2015 Myofibroblasts, the major effector cells in pathologic fibrosis, derive from the differentiation of fibroblasts driven by mediators such as transforming growth factor-β1 (TGF-β1) and biomechanical signals.
S. Wettlaufer +4 more
semanticscholar +1 more source
Bronchoprotective role for endogenous prostaglandin E2
The Lancet, 1995 The possibility that impaired production of bronchoprotective factors contributes to the pathogenesis of asthma cannot be excluded. Prostaglandin E2 (PGE2) could be such a factor. It is a dominant cyclo-oxygenase product of airway epithelium and smooth muscle; it has inhibitory effects on inflammatory cells and pathways involved in bronchoconstriction ...
Pavord, I, Tattersfield, A
openaire +4 more sources
Sulforaphane inhibits prostaglandin E2 synthesis by suppressing microsomal prostaglandin E synthase 1. [PDF]
PLoS ONE, 2012 Sulforaphane (SFN) is a dietary cancer preventive with incompletely characterized mechanism(s) of cancer prevention. Since prostaglandin E2 (PGE2) promotes cancer progression, we hypothesized that SFN may block PGE2 synthesis in cancer cells.
Jiping Zhou +3 more
doaj +1 more source
Prostaglandin E2 and the EP receptors in malignancy: possible therapeutic targets?
British Journal of Pharmacology, 2015 Elevated expression of COX‐2 and increased levels of PGE2 are found in numerous cancers and are associated with tumour development and progression.
G. O’Callaghan, A. Houston
semanticscholar +1 more source
The Effects of Bee Venom on PLA2, COX-2, iNOS, AA and PG in RAW 264.7 Cells
Journal of Pharmacopuncture, 2002 Objectives : The purpose of this study was to investigate the effect of Bee Venom on the lipopolysaccharide-induced expression phospholipase A2, cyclooxygenase-2 and inducible nitrogen oxide synthase, and the generation of arachidonic acid, prostaglandin
Hyun-Chul Jo +3 more
doaj +1 more source
Is the anti-filarial drug diethylcarbamazine useful to treat COVID-19? [PDF]
arXiv, 2020 The SARS-CoV-2 virus has resulted in a devastating pandemic of COVID-19. Exploring compounds that could offer a breakthrough in treatment is the need of the hour. Re-positioning cheap, freely available and safe drugs is a priority. The paper proposes evidence for the potential use of diethylcarbamazine (DEC) in the treatment of COVID-19.
arxiv