Cytoprotection by prostaglandins
Prostaglandins (PG) are a group of ZO-carbon oxy- genated fatty acids that are present in most mamma- lian cells and tissues. Approximately 20 of these chemicals have been identified in tissues and body fluids, whereas hundreds have been synthesized as analogs or derivatives of the natural PG.
A. Robert
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Lactones in the Synthesis of Prostaglandins and Prostaglandin Analogs [PDF]
In the total stereo-controlled synthesis of natural prostaglandins (PGs) and their structural analogs, a vast class of compounds and drugs, known as the lactones, are encountered in a few key steps to build the final molecule, as: δ-lactones, γ-lactones, and 1,9-, 1,11-, and 1,15-macrolactones.
Constantin Tănase+2 more
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Observations from 1930 to 1934 have indicated autopharmacological effects of human seminal fluid. The active principle was shown to be an unsaturated lipid‐soluble acid. After isolation in 1960 of two closely related compounds, the chemical constitution was established.
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Prostaglandins and prostaglandin receptor antagonism in migraine [PDF]
Human models of headache may contribute to understanding of prostaglandins' role in migraine pathogenesis. The current thesis investigated the migraine triggering effect of prostaglandin E2 (PGE2) in migraine patients without aura, the efficacy of a novel EP4 receptor antagonist, BGC20-1531, in prevention of PGE2-induced headache and the ability of ...
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Biosynthesis of Prostaglandins [PDF]
Highly purified cyclooxygenase from sheep vesicular glands is stimulated by the presence of protoporphyrin IX compounds. This stimulation may be due to the conversion of an apoenzyme to the holoenzyme, and full activity is achieved when half of the enzyme subunits (70,000 daltons) bind heme.
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Expression of Concern: Assessing clinical and morphological features of megalotrichosis induced by Tyrosine kinase inhibitors versus Prostaglandins analogues. [PDF]
PLOS One Editors.
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Exploring Oxylipins in Host-Microbe Interactions and Their Impact on Infection and Immunity. [PDF]
Neff RJ, Radka CD.
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Author Correction: Serum vitamin D levels and their correlation with pro-inflammatory prostaglandins in Acute myeloid leukemia: a cross-sectional analysis. [PDF]
Moghaddam HG+4 more
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Uterotonic agents for preventing postpartum haemorrhage: a network meta-analysis. [PDF]
Gallos ID+7 more
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Changes in microbial and metabolic profiles of mice fed with long-term high salt diet. [PDF]
Tian H, Gao X, Du H, Lin Z, Huang X.
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