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Prostaglandin E synthase

Prostaglandins & Other Lipid Mediators, 2002
Prostaglandin E synthase (PGES), which converts cyclooxygenase (COX)-derived prostaglandin (PG)H2 to PGE2, occurs in multiple forms with distinct enzymatic properties, modes of expression, cellular and subcellular localizations and intracellular functions.
Makoto, Murakami   +3 more
openaire   +2 more sources

Specific reduction of E prostaglandins to F.alpha. prostaglandins and prostaglandin E2 to prostaglandin E1

Journal of the American Chemical Society, 1971
This is an explanation of 2 highly specific reductive processes for the interconversion of primary PGs (prostaglandins). The laboratory procedures are described in detail and the chemical structures of substances involved in the process are diagrammed. A stereospecific reduction of PGE to PGFalpha is described.
E J, Corey, R K, Varma
openaire   +2 more sources

Prostaglandin E2-induced inflammation: Relevance of prostaglandin E receptors

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2015
Prostaglandin E2 (PGE2) is one of the most typical lipid mediators produced from arachidonic acid (AA) by cyclooxygenase (COX) as the rate-limiting enzyme, and acts on four kinds of receptor subtypes (EP1-EP4) to elicit its diverse actions including pyrexia, pain sensation, and inflammation.
Kohichi, Kawahara   +4 more
openaire   +2 more sources

Prostaglandin E receptors and the kidney

American Journal of Physiology-Renal Physiology, 2000
Prostaglandin E2is a major renal cyclooxygenase metabolite of arachidonate and interacts with four G protein-coupled E-prostanoid receptors designated EP1, EP2, EP3, and EP4. Through these receptors, PGE2modulates renal hemodynamics and salt and water excretion. The intrarenal distribution and function of EP receptors have been partially characterized,
M D, Breyer, R M, Breyer
openaire   +2 more sources

Prostaglandin e biosynthesis during cardiopulmonary bypass

Journal of Surgical Research, 1978
Abstract Initiation of cardiopulmonary bypass (CPB) causes immediate drop in blood pressure and peripheral vascular resistance (PVR) with activation of complex neurohumoral reflex mechanisms and redistribution of systemic blood flow. Prostaglandin E (PGE) is a potent vasodilator released during ischemia and low flow states. This study was designed to
C R, Saunders   +3 more
openaire   +2 more sources

Prostaglandin E in peptic ulcer disease

Prostaglandins, 1974
Abstract Prostaglandin E 1 and E 2 inhibit gastric secretion in vivo and in vitro under a variety of conditions. It is not known whether these compounds may play a role in normal gastric secretory physiology or in the pathophysiology of peptic ulcer disease.
J G, Hinsdale, J J, Engel, D E, Wilson
openaire   +2 more sources

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