Results 31 to 40 of about 18,716,571 (404)

Bromoenol Lactone, an Inhibitor of Calcium-Independent Phospholipase A2, Suppresses Carrageenan-Induced Prostaglandin Production and Hyperalgesia in Rat Hind Paw

open access: yesMediators of Inflammation, 2015
Prostaglandin (PG) E2 and PGI2 are essential to hyperalgesia in inflammatory tissues. These prostaglandins are produced from arachidonic acid, which is cleaved from membrane phospholipids by the action of phospholipase A2 (PLA2). Which isozyme of PLA2 is
Keiichiro Tsuchida   +2 more
doaj   +1 more source

Prostaglandins and related factors: XIX. Thin-layer chromatography of prostaglandins

open access: yesJournal of Lipid Research, 1964
Methods are described for separation of all known prostaglandins and some derivatives as free acids and methyl esters by thin-layer chromatography both on analytical and preparative scales. The use of silica gel containing silver nitrate was required for
Krister Gréen, Bengt Samuelsson
doaj   +1 more source

Biochemical warfare on the reef: the role of glutathione transferases in consumer tolerance of dietary prostaglandins. [PDF]

open access: yesPLoS ONE, 2010
BACKGROUND: Despite the profound variation among marine consumers in tolerance for allelochemically-rich foods, few studies have examined the biochemical adaptations underlying diet choice. Here we examine the role of glutathione S-transferases (GSTs) in
Kristen E Whalen   +3 more
doaj   +1 more source

Choline Glycerophospholipid-Derived Prostaglandins Attenuate TNFα Gene Expression in Macrophages via a cPLA2α/COX-1 Pathway

open access: yesCells, 2021
Macrophages are professional antigen presenting cells with intense phagocytic activity, strategically distributed in tissues and cavities. These cells are capable of responding to a wide variety of innate inflammatory stimuli, many of which are signaled ...
Alma M. Astudillo   +5 more
doaj   +1 more source

Effects of prostaglandins on LDL receptor activity and cholesterol synthesis in freshly isolated human mononuclear leukocytes.

open access: yesJournal of Lipid Research, 1988
The effects of prostaglandin (PG) E1, PGE2, the stable prostacyclin analogue Iloprost, and PGF2 alpha on low density lipoprotein (LDL) receptor activity and cholesterol synthesis were investigated in freshly isolated human mononuclear leukocytes ...
W Krone   +4 more
doaj   +1 more source

Preparation of Prostaglandin F from Prostaglandin E. Prostaglandins and Related Factors. 6. [PDF]

open access: yesActa Chemica Scandinavica, 1962
Reduction of prostaglandin E (PGE) with sodium borohydride yielded 2 compounds 1 of which is identical with PGF isolated from the prostate of sheep and the other of which had different physical and biological properties but the same elementary composition. The former was designated PGF1 and the latter PGF2.
Sune Bergström   +5 more
openaire   +1 more source

Upregulation of prostaglandin E2 by inducible microsomal prostaglandin E synthase-1 in colon cancer [PDF]

open access: yesAnnals of Coloproctology, 2022
Purpose: Prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) is known to promote carcinogenesis and cancer progression in colon cancer. Enzymes involved in the metabolism of PGE<sub>2</sub> include cyclooxygenase (COX)-2, microsomal prostaglandin E synthase-1 (mPGES-1), and 15-prostaglandin dehydrogenase (15-PGDH).
Young Hun Kim, Kyung Jong Kim
openaire   +2 more sources

Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission. [PDF]

open access: yes, 2017
Linoleic acid (LA; 18:2 n-6), the most abundant polyunsaturated fatty acid in the US diet, is a precursor to oxidized metabolites that have unknown roles in the brain.
Bazinet, Richard P   +11 more
core   +1 more source

Initiation of bone resorption by the classical and alternative C pathways and its mediation by prostaglandins.

open access: yesJournal of Immunology, 1977
Activation of C by immunoglobulins reactive with cell surface antigens stimulated synthesis of prostaglandin E and resultant release of 45Ca from organ cultures of fetal rat bones labeled in utero.
A. Sandberg   +4 more
semanticscholar   +1 more source

Expression and clinical implication of cyclooxygenase-2 and E-cadherin in oral squamous cell carcinomas

open access: yesCancer Biology & Therapy, 2020
Epithelial-Mesenchymal Transition (EMT) and angiogenesis are crucial events for development of aggressive and often fatal Oral Squamous Cell Carcinomas (OSCCs).
Angela Santoro   +12 more
doaj   +1 more source

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