Results 41 to 50 of about 18,922,836 (351)

Localization of the succinate receptor in the distal nephron and its signaling in polarized MDCK cells [PDF]

, 2009
When the succinate receptor (SUCNR1) is activated in the afferent arterioles of the glomerulus it increases renin release and induces hypertension.
Deen, Fenton, Francke, Gimenez, Goldsmith, Graeme Milligan, He, Hems, Henrich, Hochachka, Horst Schweer, Janos Peti-Peterdi, Jassem, Joris H. Robben, Kang, Leslie, May, Murdoch, Nordmann, Pajor, Peter M.T. Deen, Raman, Robben, Robert A. Fenton, Rohrwasser, Rohrwasser, Sadagopan, Sakai, Sapieha, Sarah L. Vargas, Schweer, Tamma, Toma, van Beest, Vargas, Weinberg, Wittenberger, Zelenina   +37 more
core   +1 more source

The induction of preterm labor in rhesus macaques is determined by the  strength of immune response to intrauterine infection.

PLoS Biology, 2021
Intrauterine infection/inflammation (IUI) is a major contributor to preterm labor (PTL). However, IUI does not invariably cause PTL. We hypothesized that quantitative and qualitative differences in immune response exist in subjects with or without PTL ...
Monica Cappelletti, Pietro Presicce, Ma Feiyang, Paranthaman Senthamaraikannan, Lisa A Miller, Matteo Pellegrini, Myung S Sim, Alan H Jobe, Senad Divanovic, Sing Sing Way, Claire A Chougnet, Suhas G Kallapur   +11 more
doaj   +1 more source

Recombinant interleukin-1β dilates steelhead trout coronary microvessels : effect of temperature and role of the endothelium, nitric oxide and prostaglandins [PDF]

, 2015
© 2015. Published by The Company of Biologists Ltd. Acknowledgements We thank Wenjuan Xu and Xin Xu (Hein Lab) for their excellent instruction in microvessel techniques, Dr David Heeley (Biochemistry Department, MUN) for assistance with selecting an ...
Amelio, Amelio, Andreakis, Bataillard, Beasley, Berne, Buonocore, Chilian, Chiu, Combes, Costa, Dinarello, Duling, Duncan, Fago, Farrell, Farrell, Farrell, Farrell, Fritsche, Gamperl, Gamperl, Gamperl, Gollock, González-Domenech, Graff, Gräns, Hein, Helwig, Hirafuji, Holland, Hong, Hong, Imbrogno, Ishizaka, Jedrzejowska-Szypulka, Jennings, Kanno, Kiceniuk, Kuo, Kuo, Kågström, Leon, Lepiller, Lin, Lüscher, Maher, Marceau, McKean, McNeill, Miller, Mollace, Mustafa, Mustafa, Nilsson, Oliveira, Olson, Olson, Olson, Olson, Osuka, Park, Peddie, Peddie, Perry, Proescholdt, Pérez-Casanova, Radin, Rossi, Salvemini, Schiltz, Shi, Shibata, Shimokawa, Taniguchi, Tsujino, Vassalle, Wang, Warner, Warner, Zou, Zou   +81 more
core   +3 more sources

Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids. [PDF]

, 2016
The beta amyloid (Aβ) and other aggregating proteins in the brain increase with age and are frequently found within neurons. The mechanistic relationship between intracellular amyloid, aging and neurodegeneration is not, however, well understood.
Currais, Antonio, Daugherty, Daniel, M Armando, Aaron, Maher, Pam, Quehenberger, Oswald, Schubert, David   +5 more
core   +2 more sources

Metabolism of prostaglandins E, A, and C in serum

Journal of Biological Chemistry, 1975
Three prostaglandin-metabolizing enzymes were detected in human serum. One enzyme was a dehydrase that converted prostaglandin E to prostaglandin A, the second was a prostaglandin A isomerase that converted prostaglandin A to prostaglandin C and the third was a prostaglandin C isomerase that converted prostaglandin C to prostaglandin B.
L Levine, H Polet
openaire   +3 more sources

Conserved and species-specific oxylipin pathways in the wound-activated chemical defense of the noninvasive red alga Gracilaria chilensis and the invasive Gracilaria vermiculophylla

Beilstein Journal of Organic Chemistry, 2012
Chemical defense of the invasive red alga Gracilaria vermiculophylla has been studied and compared to that of the noninvasive but related Gracilaria chilensis. Both species rely on a wound-activated chemical defense that makes them less attractive to the
Martin Rempt, Florian Weinberger, Katharina Grosser, Georg Pohnert   +3 more
doaj   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

METHOD FOR MODULATING EICOSANOID MEDIATED IMMUNE RESPONSES IN ARTHROPODS [PDF]

, 2000
The invention is directed to compositions which alter the health of invertebrate organisms by affecting eicosanoid mediated immune responses, and methods of using the compositions.
Stanley, David W.
core   +1 more source

Preparation of Prostaglandin F from Prostaglandin E. Prostaglandins and Related Factors. 6. [PDF]

Acta Chemica Scandinavica, 1962
Reduction of prostaglandin E (PGE) with sodium borohydride yielded 2 compounds 1 of which is identical with PGF isolated from the prostate of sheep and the other of which had different physical and biological properties but the same elementary composition. The former was designated PGF1 and the latter PGF2.
Olof Theander, Sune Bergström, Lennart Krabisch, Benny Samuelsson, H. Flood, J. Sjövall   +5 more
openaire   +2 more sources

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source