Results 111 to 120 of about 11,432 (184)

Combining biocatalytic and radical retrosynthesis for efficient chemoenzymatic synthesis of natural products.

Chem Soc Rev
Renata H.
europepmc   +1 more source

The biological functions of monoacylglycerol lipase (MAGL) in cancer. [PDF]

Saudi Pharm J
Almutairi F.
europepmc   +1 more source

NSAID ingestion augments training‐induced muscle hypertrophy and differentially affects muscle mRNA expression, but not strength gains, in trained men

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the impact of NSAID ingestion on resistance exercise training‐induced changes in muscle morphology, function and gene networks relative to placebo ingestion in trained males. Abstract Non‐steroidal anti‐inflammatory drugs (NSAIDs) are widely overused in sports.
Joanne E. Mallinson, Tariq Taylor, Dumitru Constantin‐Teodosiu, Despina Constantin, Martino V. Franchi, Dorothee Auer, Paul L. Greenhaff   +6 more
wiley   +1 more source

A concise and scalable chemoenzymatic synthesis of prostaglandins. [PDF]

Nat Commun
Yin Y, Wang J, Li J.
europepmc   +1 more source

Glucocorticoids modulate drug transporter function in human fetal brain endothelial cells

The Journal of Physiology, EarlyView.
Abstract figure legend P‐glycoprotein and breast cancer resistance protein are the most prominent drug transporters at the fetal blood–brain barrier. We isolated primary human fetal brain endothelial cells from early and mid‐gestation cerebral microvessels and exposed them to glucocorticoids cortisol and dexamethasone in vitro.
Nikola Ivanovski, Phetcharawan Lye, Enrrico Bloise, Stephen G. Matthews   +3 more
wiley   +1 more source

Chemical Profiling and Multimodal Anti-Inflammatory Activity of <i>Eugenia pyriformis</i> Leaves Essential Oil. [PDF]

Molecules
Ribeiro LS, Lourenço VG, de Souza KG, Sardinha YC, Miranda KC, Machado FP, Franchini RAA, Pereira MTM, Rocha L, Pascoal VDB, Pascoal ACRF.   +10 more
europepmc   +1 more source

Treating age‐related loss of muscle mass and function: Where should we be focusing?

The Journal of Physiology, EarlyView.
Abstract figure legend Perturbations contributing to the age‐related loss of muscle mass and strength. A, in the spinal cord, self‐reinforcing cycles of oxidative stress, mitochondrial dysfunction and inflammation mediated by cells, including microglia, contribute to motor neuron degeneration.
Daniel J. Ham, Christopher S. Fry, Avnika Ashok Ruparelia, Shyuan T. Ngo, Séverine Lamon   +4 more
wiley   +1 more source

Phospholipases A₂ (PLA₂s) and Related Peptides from <i>Bothrops</i> Snake Venoms: History, Structure, Pharmacology, and Inhibitors. [PDF]

Biomolecules
Santos ICD, Romanazzi M, Malachias-Pires GM, Aragão AR, Filardi ETM, Melo-Dos-Santos G, Salvador LC, Cerveja MF, Rocha AM, Magalhães A, de Oliveira IS, Almeida JR, Santos-Filho NA, Pucca MB.   +13 more
europepmc   +1 more source

TRIP8bnano peptide prevents cAMP binding to HCN2 channels alleviating pain‐like behaviors in rats with neuropathic pain

The Journal of Physiology, EarlyView.
Abstract figure legend We tested the hypothesis that cAMP binding to HCN2 channels in nociceptors is a causal driver of neuropathic pain by using TRIP8bnano, a synthetic peptide we previously developed as a selective antagonist of cAMP in HCN channels. TRIP8bnano effectively abolishes cAMP potentiation of HCN2 currents in small‐diameter DRG neurons and
Santiago I. Loya‐Lopez, Kimberly Gomez, Alessandro Porro, Gerhard Thiel, Anna Moroni, Heather N. Allen, Rajesh Khanna, Andrea Saponaro   +7 more
wiley   +1 more source

NRF2 as a Therapeutic Target in Dermatological Disorders: Mechanisms and Molecules. [PDF]

Pharmaceuticals (Basel)
Khiar-Fernández I, Khiar-Fernández N, Pereyra-Rodríguez JJ, Fernández I.   +3 more
europepmc   +1 more source