Results 111 to 120 of about 131,150 (281)
Cofactors in the biosynthesis of prostaglandins F and F .
Biochimica et Biophysica Acta, 1972 R. Lee, W. Lands
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Acta Ophthalmologica, EarlyView.Abstract Purpose This systematic review and meta‐analysis aim to evaluate the efficacy and safety of further lowering intraocular pressure (IOP) to single‐digit levels in treated patients with progressive normal‐tension glaucoma (NTG). Methods A literature search was conducted in MEDLINE (via PubMed), Scopus and Web of Science. We selected studies that
Beatriz Araújo‐Azevedo +2 more
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Interpreting the structure–function relationship in high myopia‐associated glaucoma: A review
Acta Ophthalmologica, EarlyView.Abstract Visual field (VF) interpretation in high myopia‐associated glaucoma (HMG) is challenging due to frequent structure–function discordance and coexisting myopia‐related changes. These changes may reduce the reliability of conventional structure–function mapping and increase the risk of misclassifying non‐glaucomatous VF abnormalities as ...
Ruby S. Chan +6 more
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Compartmentalisation in cAMP signalling: A phase separation perspective
British Journal of Pharmacology, EarlyView.Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
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Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
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British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Guanylate cyclase‐C (GC‐C) is the receptor for endogenous (uro)guanylin peptides, bacterial toxins and pharmacological analogues. Receptor activation leads to intestinal fluid loss, but also activates an antiproliferative pathway and is a promising target in colorectal cancer therapy.
Renjie Xiu +4 more
wiley +1 more source
In Vivo Effect of a Synthetic Amniotic Fluid on Fetal Lung and Gastrointestinal Tract: A Pre-Clinical Rodent Model. [PDF]
Prenat DiagnForde B, Finoti S, Oria M, Peiro JL.
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Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders
British Journal of Pharmacology, EarlyView.Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman +3 more
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Collision-Induced Gas-Phase Reactions of PFB-TMS Derivatives of F<sub>2</sub>-Prostaglandins in Quadrupole GC-NICI-MS/MS: A Mini-Review and a Meta-Analysis. [PDF]
MoleculesTsikas DS, Tsikas SA.
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