Results 121 to 130 of about 11,432 (184)

Vascular smooth muscle cell mechanotransduction: Pathways, phenotypes and emerging technologies

The Journal of Physiology, EarlyView.
Abstract figure legend Vascular smooth muscle cells are exposed to mechanical stimuli from the blood flow and the extracellular matrix. The cells sense the signals from cyclic stretch, shear stress, hydrostatic pressure and matrix stiffness through specialized mechanosensors, such as mechanosensitive ion channels or cell surface receptors including ...
Nivethitha Kota Lakshminaraasimulu, Rachel E. A. Smyth, Aishwarya Prakash, Thomas Iskratsch   +3 more
wiley   +1 more source

Thyroid antibody positivity in pregnancy is associated with altered reproductive hormone concentrations and placental growth in Lewis rats

The Journal of Physiology, EarlyView.
Abstract figure legend Thyroid antibody positivity (TAb+) in pregnancy is associated with adverse pregnancy outcomes, but the mechanisms are unclear. This study developed a rodent model of TAb+ in pregnancy, induced prior to mating so that TAb+ exposure occurred throughout the pregnancy. TAb+ did not alter thyroid hormone concentrations and had minimal
Rebecca L. Brady, Nykola L. Kent, Anna G. Reid, Liana P. Paszkowski, Ashley S. Meakin, Dayna A. Zimmerman, Dinithi T. Mahaliyanage, Elliott S. Neal, Michael D. Wiese, Helle Bielefeldt‐Ohmann, Janna L. Morrison, James S. M. Cuffe   +11 more
wiley   +1 more source

The Inflammatory Roles of n-3 and n-6 Polyunsaturated Fatty Acids in COPD: Clinical Implications and Underlying Mechanisms. [PDF]

J Inflamm Res
Wang Y, Bao Y, Liu B, Li H, Duan H, Wang Y, Zhang J, Wu W, Li P, Liu X.   +9 more
europepmc   +1 more source

Integrated Phytochemical Characterisation, Pharmacological Evaluation and Computational Investigation of Acampe papillosa Stem Extract

Analytical Science Advances, Volume 7, Issue 2, December 2026.
The pharmacological potential of the methanolic stem extract of Acampe papillosa is evaluated using in vivo and in silico approaches. The extract demonstrates significant anxiolytic, sedative, anti‐inflammatory, and antipyretic activities in experimental models, while molecular docking supports the observed biological effects through favorable ...
Qurratul Ain Sadia, Sadia Tamanna Tamim, Faruq Mohammed Tashriq, Nasir Uddin, Fatematus Zhohara Alam Hima, Ulfat Sobha Surat, Mily Khastagir, Muhammad Abdul Jalil, Md. Hossain Rasel, Arman Ullah Rafi, S. M. Moazzem Hossen   +10 more
wiley   +1 more source

Exploring the Anti-Nociceptive, Anti-Inflammatory, Anti-Pyretic, and Anti-Arthritic Activity of Methanolic Extract of <i>Desmos chinensis</i> and Its Different Solvent Fractions: In Vivo, In Vitro, and In Silico Intervention. [PDF]

Adv Pharmacol Pharm Sci
Prithy NS, Nahar A, Mamun MJI, Rasel MH, Akter F, Tahrim KS, Islam R, Emon MEH, Ihsan AB.   +8 more
europepmc   +1 more source

Inflammatory Factors in Allergic Rhinitis: A 20‐Year Bibliometric Mapping and Emerging Trends

Flavour and Fragrance Journal, Volume 41, Issue 5, Page 1076-1089, September 2026.
This figure illustrates the bibliometric process and results of research on inflammatory factors of allergic rhinitis from 2004 to 2024 including data screening, global distribution, collaborative networks and the evolution of research hotspots. ABSTRACT Allergic rhinitis (AR) is driven by a network of inflammatory mediators released by mast cells ...
Shanshan Jing, Fengying Zhang, Qiqi Liu
wiley   +1 more source

Allies or Enemies? The Power of Plant Hormones in Animals: Insights into Their Regulatory Roles. [PDF]

Molecules
Kućko A, Walczak A, Wilmowicz E, Wolski B, Wiktorska K.   +4 more
europepmc   +1 more source

Immunomodulatory and Cytotoxic Properties of Enniatin B1 in Porcine Alveolar Macrophages

Journal of Applied Toxicology, Volume 46, Issue 9, Page 3220-3231, September 2026.
ABSTRACT This study investigates the immunomodulatory effects of Enniatin B1 (ENNB1), an emerging mycotoxin, on porcine alveolar macrophages (PAMs), a species‐specific model relevant to human innate immunity. PAMs were exposed to increasing ENNB1 concentrations (0.5–6 μM) over 6, 24, and 48 h.
Sara Frazzini, Francesca Caloni, Paola Fossati, Giancarlo Ruffo, Luciana Rossi   +4 more
wiley   +1 more source

Lipid Metabolism and Obesity in Early Life: Drivers of Chronic Lung Disease From Development to Adulthood. [PDF]

Mol Nutr Food Res
Selle J, Mierswa N, Saschin L, Niehues J, Dötsch J, Nüsken E, Nüsken KD, Schipke J, Alejandre Alcazar MA.   +8 more
europepmc   +1 more source

A Porcine Model of Intervertebral Disc Injury Recapitulates Human Discogenic Pain Via Notochordal Cell Loss and Pain‐Inducing Nucleus Pulposus Cell Emergence

JOR SPINE, Volume 9, Issue 3, September 2026.
A porcine model of disc injury recapitulates key clinical, histological, and molecular features of human discogenic low back pain. Multi‐omics analyses identify a shift from notochordal cells to pain‐associated nucleus pulposus cells as a potential driver of disease progression. ABSTRACT Background Lower back pain (LBP) is one of the most common causes
Giselle Kaneda, Jacob T. Wechsler, Melissa Chavez, Julia Sheyn, Karandeep Cheema, Chushu Shen, Dante Rigo De Righi, Lixia Wang, Yin‐Chen Hsu, Pablo Avalos, Yibin Xie, Wafa Tawackoli, Candace Floyd, Debiao Li, Dmitriy Sheyn   +14 more
wiley   +1 more source