Results 31 to 40 of about 257,390 (240)
Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer
Molecular Oncology, EarlyView.This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu +7 more
wiley +1 more source
Is the anti-filarial drug diethylcarbamazine useful to treat COVID-19? [PDF]
arXiv, 2020 The SARS-CoV-2 virus has resulted in a devastating pandemic of COVID-19. Exploring compounds that could offer a breakthrough in treatment is the need of the hour. Re-positioning cheap, freely available and safe drugs is a priority. The paper proposes evidence for the potential use of diethylcarbamazine (DEC) in the treatment of COVID-19.
arxiv
Improving the Effectiveness of Deep Generative Data [PDF]
arXiv, 2023 Recent deep generative models (DGMs) such as generative adversarial networks (GANs) and diffusion probabilistic models (DPMs) have shown their impressive ability in generating high-fidelity photorealistic images. Although looking appealing to human eyes, training a model on purely synthetic images for downstream image processing tasks like image ...
arxiv
Molecular Oncology, EarlyView.FOXL2 c.402C>G mutation drives granulosa cell tumors. Using CRISPR technology, we selectively corrected this mutation, reducing malignancy and increasing sensitivity to dasatinib and ketoconazole. Transcriptomic changes revealed potential therapeutic targets, demonstrating CRISPR's promise for treating this rare ovarian cancer.
Sandra Amarilla‐Quintana +17 more
wiley +1 more source
Understanding and measuring mechanical signals in the tumor stroma
FEBS Open Bio, EarlyView.This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz +3 more
wiley +1 more source
Advanced Materials Interfaces, EarlyView.This study investigates the impact of nanostructured surface modification on corrosion resistance, HUVEC functions, and platelet interactions of 316L SS for cardiovascular stents. Nanostructured surfaces enhanced HUVEC proliferation, migration, and angiogenesis‐related gene expression while reducing platelet adhesion and hemolysis.
Yasar Kemal Erdogan +2 more
wiley +1 more source
Organopalladium approaches to prostaglandins [PDF]
, 1991 Organopalladium chemistry has found considerable synthetic utility in organic chemistry. Advances in this chemistry led us to develop several efficient new synthetic routes to prostaglandins, hormones which have a host of regulatory functions in the ...
Lee, Nam Ho
core +2 more sources
Achieving Optimal Health With Host‐Directed Therapies (HDTs) in Infectious Diseases—A New Horizon
Advanced Therapeutics, EarlyView.Host‐directed therapies (HDTs) represent a transformative approach in infectious disease management by targeting host factors to enhance immune responses and inhibit viral replication. This innovative strategy leverages advanced genomics and gene editing technologies, offering promising avenues for improved patient outcomes and a new horizon in ...
Amol D. Gholap +10 more
wiley +1 more source
A new PCA-based utility measure for synthetic data evaluation [PDF]
arXiv, 2022 Data synthesis is a privacy enhancing technology aiming to produce realistic and timely data when real data is hard to obtain. Utility of synthetic data generators (SDGs) has been investigated through different utility metrics. These metrics have been found to generate conflicting conclusions making direct comparison of SDGs surprisingly difficult ...
arxiv
Involvement of leukotriene pathway in the pathogenesis of ischemia-reperfusion injury and septic and non-septic shock. [PDF]
, 2009 The 5-lipoxygenase (5-LO) pathway is responsible for the production of leukotrienes (LTs), inflammatory lipid mediators which play a role in innate immunity. More recently, a pivotal role of LTs in ischemia-reperfusion and shock injury has been suggested.
CUZZOCREA S +2 more
core +1 more source