Results 21 to 30 of about 9,740,708 (263)
Trypanosoma cruzi infection and endothelin-1 cooperatively activate pathogenic inflammatory pathways in cardiomyocytes. [PDF]
PLoS Neglected Tropical Diseases, 2013 Trypanosoma cruzi, the causative agent of Chagas' disease, induces multiple responses in the heart, a critical organ of infection and pathology in the host.
Ricardo S Corral +4 more
doaj +1 more source
Modeling of biological doses and mechanical effects on bone transduction [PDF]
Journal of Theoretical Biology 274, 1 (2011) 36-42, 2011 Shear stress, hormones like parathyroid and mineral elements like calcium mediate the amplitude of stimulus signal which affects the rate of bone remodeling. The current study investigates the theoretical effects of different metabolic doses in stimulus signal level on bone.
arxiv +1 more source
Journal of Biological Chemistry, 2001 Electrophilic eicosanoids of the J series, with their distinctive cross-conjugated α,β-unsaturated ketone, inactivate genetically wild type tumor suppressor p53 in a manner analogous to prostaglandins of the A series.
J. Mullally +3 more
semanticscholar +1 more source
Aldo-keto reductases 1B in adrenal cortex physiology
Frontiers in Endocrinology, 2016 Aldose reductase proteins are cytosolic monomeric enzymes, belonging to the aldo-keto reductase (AKR) superfamily. They perform oxidoreduction of carbonyl groups from a wide variety of substrates such as aliphatic and aromatic aldehydes or ketones.
Emilie PASTEL +3 more
doaj +1 more source
Inactivation of wild-type p53 tumor suppressor by electrophilic prostaglandins.
Proceedings of the National Academy of Sciences of the United States of America, 2000 The electrophilic eicosanoids prostaglandins A(1) or A(2) impaired p53-dependent transcription of endogenous genes and exogenous p53-luciferase reporter plasmids in RKO and HCT 116 colon cancer cells.
P. Moos, K. Edes, F. Fitzpatrick
semanticscholar +1 more source
Heliyon, 2023 Background: Most labor-related problems can be attributed to the uterine myometrium muscle, as this irritable tissue must suppress its irritability potential during pregnancy.
Farideh Zafari Zangeneh +1 more
doaj
Preparation of Prostaglandin F from Prostaglandin E. Prostaglandins and Related Factors. 6. [PDF]
Acta Chemica Scandinavica, 1962 Reduction of prostaglandin E (PGE) with sodium borohydride yielded 2 compounds 1 of which is identical with PGF isolated from the prostate of sheep and the other of which had different physical and biological properties but the same elementary composition. The former was designated PGF1 and the latter PGF2.
Olof Theander +5 more
openaire +2 more sources
Aldo keto reductase 1B7 and prostaglandin F2alpha are regulators of adrenal endocrine functions. [PDF]
PLoS ONE, 2009 Prostaglandin F(2alpha) (PGF(2alpha)), represses ovarian steroidogenesis and initiates parturition in mammals but its impact on adrenal gland is unknown.
Sarah Lambert-Langlais +13 more
doaj +1 more source
Endogenous prostaglandins in peptic ulcer disease.
Gut, 1979 Plasma concentrations of prostaglandins E and F have been measured by radioimmunoassay in patients undergoing diagnostic upper intestinal endoscopy. The results fail to support a previously reported deficiency of plasma PGE in duodenal ulcer patients ...
R. Baker, B. Jaffe, C. Venables
semanticscholar +1 more source
Molecules, 2018 Cyclooxygenase 2 (COX-2) is an inducible enzyme responsible for the conversion of arachidonic acid into the prostaglandins, PGG2 and PGH2. Expression of this enzyme increases in inflammation.
Michelle Y. Cortes-Salva +8 more
doaj +1 more source