Results 1 to 10 of about 1,302,201 (345)

Lutetium-177-PSMA-617 for Metastatic Castration-Resistant Prostate Cancer.

New England Journal of Medicine, 2021
BACKGROUND Metastatic castration-resistant prostate cancer remains fatal despite recent advances. Prostate-specific membrane antigen (PSMA) is highly expressed in metastatic castration-resistant prostate cancer.
O. Sartor, J. D. de Bono, K. Chi, K. Fizazi, K. Herrmann, K. Rahbar, S. Tagawa, L. Nordquist, N. Vaishampayan, G. El-Haddad, Chandler Park, T. Beer, A. Armour, Wendy J Pérez-Contreras, M. Desilvio, E. Kpamegan, G. Gericke, R. Messmann, M. Morris, B. Krause   +19 more
semanticscholar   +1 more source

Prostate Cancer, Version 4.2023, NCCN Clinical Practice Guidelines in Oncology.

The Journal of the National Comprehensive Cancer Network, 2023
The NCCN Guidelines for Prostate Cancer provide a framework on which to base decisions regarding the workup of patients with prostate cancer, risk stratification and management of localized disease, post-treatment monitoring, and treatment of recurrence ...
E. Schaeffer, Sandy Srinivas, N. Adra, Yi An, Daniel L Barocas, Rhonda L. Bitting, Alan H Bryce, B. Chapin, Heather H. Cheng, A. D'Amico, Neil Desai, Tanya B. Dorff, James A. Eastham, T. Farrington, Xin Gao, Shilpa Gupta, Thomas Guzzo, Joseph E Ippolito, M. Kuettel, J. Lang, T. Lotan, Rana R. McKay, Todd Morgan, George Netto, J. Pow‐Sang, Robert Reiter, M. Roach, Tyler Robin, Stan Rosenfeld, Ahmad Shabsigh, Daniel Spratt, Benjamin A. Teply, J. Tward, R. Valicenti, J. K. Wong, Dorothy Shead, Jenna Snedeker, Deborah A. Freedman-Cass   +37 more
semanticscholar   +1 more source

Androgen receptor (AR) antagonism triggers acute succinate‐mediated adaptive responses to reactivate AR signaling

EMBO Molecular Medicine, 2021
Treatment‐induced adaptive pathways converge to support androgen receptor (AR) reactivation and emergence of castration‐resistant prostate cancer (PCa) after AR pathway inhibition (ARPI). We set out to explore poorly defined acute adaptive responses that
Neetu Saxena, Eliana Beraldi, Ladan Fazli, Syam Prakash Somasekharan, Hans Adomat, Fan Zhang, Chidi Molokwu, Anna Gleave, Lucia Nappi, Kimberly Nguyen, Pavn Brar, Nicholas Nikesitch, Yuzhuo Wang, Colin Collins, Poul H Sorensen, Martin Gleave   +15 more
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Translating the prostate cancer survivorship essentials framework into clinical practice: a participatory research process analysis

Cancer Survivorship Research & Care, 2023
Purpose: Accessible cancer survivorship care is a key tenet of quality cancer care. However, prostate cancer survivorship care is often fragmented with best practice models of care largely undefined. The Prostate Cancer Survivorship Essentials Framework (
Nicole Heneka, Helen Crowe, Suzanne K. Chambers, Anthony Costello, Jane Crowe, Phil Dundee, Rachel Heerey, Elles Stijnen, Chris Bolger, Isabelle Schaefer, Jeff Dunn   +10 more
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Examining the influence of illness perception and financial toxicity on the quality of life of prostate cancer patients

African Journal of Urology, 2021
Background Cancer of the prostate (CaP) is a public health problem that affects the male genitourinary system causing a significant threat to men’s quality of life (QoL).
Elizabeth O. Akin-Odanye, Chidiebere N. Ogo, Faoziyat A. Sulaiman, Lawal Suleiman, Motolani E. Ogunsanya, Folakemi T. Odedina   +5 more
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Dependency of Tamoxifen Sensitive and Resistant ER⁺ Breast Cancer Cells on Semaphorin 3C (SEMA3C) for Growth

Cells, 2023
Estrogen receptor positive (ER+) breast cancer (BCa) accounts for the highest proportion of breast cancer-related deaths. While endocrine therapy is highly effective for this subpopulation, endocrine resistance remains a major challenge and the ...
Satyam Bhasin, Christopher Dusek, James W. Peacock, Artem Cherkasov, Yuzhuo Wang, Martin Gleave, Christopher J. Ong   +6 more
doaj   +1 more source

Prostate Cancer Review: Genetics, Diagnosis, Treatment Options, and Alternative Approaches

Molecules, 2022
Simple Summary Prostate cancer affects men of all racial and ethnic groups and leads to higher rates of mortality in those belonging to a lower socioeconomic status due to late detection of the disease.
M. Sekhoacha, Keamogetswe Riet, Paballo Motloung, Lemohang Gumenku, A. Adegoke, S. Mashele   +5 more
semanticscholar   +1 more source

BAP1 haploinsufficiency predicts a distinct immunogenic class of malignant peritoneal mesothelioma

Genome Medicine, 2019
Background Malignant peritoneal mesothelioma (PeM) is a rare and fatal cancer that originates from the peritoneal lining of the abdomen. Standard treatment of PeM is limited to cytoreductive surgery and/or chemotherapy, and no effective targeted ...
Raunak Shrestha, Noushin Nabavi, Yen-Yi Lin, Fan Mo, Shawn Anderson, Stanislav Volik, Hans H. Adomat, Dong Lin, Hui Xue, Xin Dong, Robert Shukin, Robert H. Bell, Brian McConeghy, Anne Haegert, Sonal Brahmbhatt, Estelle Li, Htoo Zarni Oo, Antonio Hurtado-Coll, Ladan Fazli, Joshua Zhou, Yarrow McConnell, Andrea McCart, Andrew Lowy, Gregg B. Morin, Tianhui Chen, Mads Daugaard, S. Cenk Sahinalp, Faraz Hach, Stephane Le Bihan, Martin E. Gleave, Yuzhuo Wang, Andrew Churg, Colin C. Collins   +32 more
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The diagnostic accuracy of multiparametric MRI for detection and localization of prostate cancer depends on the affected region

BJUI Compass, 2021
Objectives To determine the diagnostic accuracy of 3T multiparametric magnetic resonance imaging (mpMRI) for detecting and locating prostate cancer (PCa) on Dickinson's 27‐sector map, using histopathology specimens from radical prostatectomy (RP) as the ...
Martina Martins, Stefano Regusci, Stephane Rohner, Ildiko Szalay‐Quinodoz, Georges‐Antoine De Boccard, Louise Strom, Gerjon Hannink, Sonia Ramos‐Pascual, Charles Henry Rochat   +8 more
doaj   +1 more source

SEMA3C drives cancer growth by transactivating multiple receptor tyrosine kinases via Plexin B1

EMBO Molecular Medicine, 2018
Growth factor receptor tyrosine kinase (RTK) pathway activation is a key mechanism for mediating cancer growth, survival, and treatment resistance. Cognate ligands play crucial roles in autocrine or paracrine stimulation of these RTK pathways.
James W Peacock, Ario Takeuchi, Norihiro Hayashi, Liangliang Liu, Kevin J Tam, Nader Al Nakouzi, Nastaran Khazamipour, Tabitha Tombe, Takashi Dejima, Kevin CK Lee, Masaki Shiota, Daksh Thaper, Wilson CW Lee, Daniel HF Hui, Hidetoshi Kuruma, Larissa Ivanova, Parvin Yenki, Ivy ZF Jiao, Shahram Khosravi, Alice L‐F Mui, Ladan Fazli, Amina Zoubeidi, Mads Daugaard, Martin E Gleave, Christopher J Ong   +24 more
doaj   +1 more source