Results 111 to 120 of about 670,718 (407)

Examining the Efficacy of Screening with Prostate-Specific Antigen Testing in Reducing Prostate Cancer Mortality [PDF]

, 2012
Prostate cancer is a prevalent, worldwide problem among male adults. This literature review, “Examining the Efficacy of Screening with Prostate-Specific Antigen Testing in Reducing Prostate Cancer Mortality,” focuses on a safe and effective screening ...
Leake, Rachel
core   +1 more source

Baseline Prostate-Specific Antigen Levels in Midlife Predict Lethal Prostate Cancer.

Journal of Clinical Oncology, 2016
PURPOSE Prostate-specific antigen (PSA) level in midlife predicted future prostate cancer (PCa) mortality in an unscreened Swedish population. Our purpose was to determine if a baseline PSA level during midlife predicts lethal PCa in a US population with
M. Preston, Julie L. Batista, K. Wilson, S. Carlsson, T. Gerke, D. Sjoberg, D. Dahl, H. Sesso, A. Feldman, P. Gann, A. Kibel, A. Vickers, L. Mucci   +12 more
semanticscholar   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Developing a consensus statement for psychosocial support in active surveillance for prostate cancer

BJUI Compass, Volume 4, Issue 1, Page 104-113, January 2023., 2023
Abstract Purpose Our objective was to prioritise the psychosocial support needs of men on active surveillance for prostate cancer and to develop a consensus statement to provide guidance on best practice psychosocial support for men choosing active surveillance and their families.
Kerri Beckmann, Declan Cahill, Christian Brown, Mieke Van Hemelrijck, Netty Kinsella   +4 more
wiley   +1 more source

Comparison of the Diagnostic Performance of Multiparametric Prostate Magnetic Resonance Imaging Results with Classical Parameters for Prostate Carcinoma in Gray Zone Patients

Journal of Urological Surgery
Objective: To compare the diagnostic value of prostate imaging-reporting and data system (mpMRI) version 2.0 with classical parameters for prostate cancer detection in gray zone patients with ultrasonography-guided prostate biopsy as a reference point ...
Coşkun Bostancı, Demirhan Örsan Demir
doaj   +1 more source

Discrimination of Membrane Antigen Affinity by B cells Requires Dominance of Kinetic Proofreading over Serial Triggering [PDF]

arXiv, 2010
B cells receptor (BCR) signaling in response to membrane-bound antigen increases with antigen affinity, a process known as affinity discrimination. We use computational modeling to show that B cell affinity discrimination requires that kinetic proofreading predominate over serial engagement.
arxiv  

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Combining PSA and PET features to select candidates for salvage lymph node dissection in recurrent prostate cancer

BJUI Compass, Volume 4, Issue 1, Page 123-129, January 2023., 2023
Abstract Objective To evaluate the relationship between pre‐operative PSA value, 68Ga‐prostate‐specific‐membrane‐antigen (PSMA) PET performance and oncologic outcomes after salvage lymph node dissection (sLND) for biochemical recurrent prostate cancer (PCa).
Carlo A. Bravi, Axel Heidenreich, Nicola Fossati, Giorgio Gandaglia, Nazareno Suardi, Elio Mazzone, Armando Stabile, Vito Cucchiara, Daniar Osmonov, Klaus‐Peter Juenemann, R. Jeffrey Karnes, Alexander Kretschmer, Alexander Buchner, Christian Stief, Andreas Hiester, Peter Albers, Gaëtan Devos, Steven Joniau, Hendrik Van Poppel, Bernhard Grubmüller, Shahrokh Shariat, Derya Tilki, Markus Graefen, Inderbir S. Gill, Alexander Mottrie, Pierre I. Karakiewicz, Francesco Montorsi, Alberto Briganti, David Pfister   +28 more
wiley   +1 more source

Review article: Prostate cancer screening using prostate specific antigen: Controversies and recommendations [PDF]

, 2016
Background: Prostate cancer is the commonest cancer among men in Nigeria and early detection is key to cure and survival but its screening through prostate specific antigen (PSA) has remain controversial in literature.
Agbo, CA, Shuaibu, SI
core   +2 more sources

Linker Modification Strategies To Control the Prostate-Specific Membrane Antigen (PSMA)-Targeting and Pharmacokinetic Properties of DOTA-Conjugated PSMA Inhibitors.

Journal of Medicinal Chemistry, 2016
Since prostate-specific membrane antigen (PSMA) is up-regulated in nearly all stages of prostate cancer (PCa), PSMA can be considered as a viable diagnostic biomarker and treatment target in PCa.
M. Benešová, U. Bauder-Wüst, M. Schäfer, K. Klika, W. Mier, U. Haberkorn, K. Kopka, M. Eder   +7 more
semanticscholar   +1 more source