Molecular Carcinogenesis, EarlyView.ABSTRACT Hypoxia and nutrient deprivation are fundamental drivers of tumor aggressiveness and therapeutic resistance in hepatocellular carcinoma (HCC). While the involvement of neural components in the tumor microenvironment (TME) is increasingly recognized, the molecular transducers linking metabolic stress to neuron–tumor crosstalk remain elusive ...
Taehyun Park +5 more
wiley +1 more source
Discrepancies in volume: impact of Artemis segmented magnetic resonance imaging, ultrasound, and ExactVu measurements on prostate specific antigen density and National Comprehensive Cancer Network risk stratification. [PDF]
Cent European J UrolRabil MJ +5 more
europepmc +1 more source
Value of prostate-specific antigen density in negative or equivocal lesions on multiparametric magnetic resonance imaging. [PDF]
Turk J Urol, 2020 Rico L +5 more
europepmc +1 more source
Prevention of Early Onset of Breast Cancer With Ashwagandha
Molecular Carcinogenesis, EarlyView.ABSTRACT Prevention of breast cancer is feasible because many risk factors for this malignancy are known (e.g., family history, reproductive factors, etc.). Medicinal plants and/or their bioactive phytochemicals are attractive for the prevention of early onset of breast cancer due to their generally favorable safety profile.
Eun‐Ryeong Hahm +2 more
wiley +1 more source
AI‐Driven Rational Design of Nanotherapeutics for Pancreatic Ductal Adenocarcinoma
Medicinal Research Reviews, EarlyView.ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains a formidable malignancy characterized by late diagnosis, high recurrence rates, and pronounced chemoresistance. While nanoparticle‐based drug delivery systems (NDDS) offer theoretical advantages over conventional therapies, their clinical translation in PDAC has been severely limited.
Seohyun Choo +4 more
wiley +1 more source
Can lesion volume and prostate-specific antigen density play a role in detecting clinically significant prostate cancer in Prostate Imaging Reporting and Data System-3 lesions on multiparametric magnetic resonance imaging? [PDF]
Indian J UrolAgrawal S +3 more
europepmc +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT Targeted elimination of pathogenic proteins remains a fundamental challenge in therapeutic intervention, particularly for proteins considered “undruggable” by conventional inhibition‐based approaches. Aptamer–based targeted protein degradation (TPD) has emerged as a versatile strategy that leverages the high specificity, structural ...
Ambrin Malik +3 more
wiley +1 more source
PROTEOMICS, EarlyView.ABSTRACT Triple‐negative breast cancer (TNBC) represents the most aggressive subtype with limited therapeutic options and the poorest clinical outcomes. Using high‐resolution nUPLC‐QTOF‐MS/MS, we performed comprehensive proteomic profiling of TNBC cell lines representing disease progression stages: HCC‐1937 (stage IIB), HCC‐1599 (stage IIIA), and MDA ...
Claudia Sissely Chaviano‐Montes de Oca +7 more
wiley +1 more source
Reduction of false positives using zone-specific prostate-specific antigen density for prostate MRI-based biopsy decision strategies. [PDF]
Eur RadiolHamm CA +15 more
europepmc +1 more source