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Beyond the Number: Interpreting Prostate-Specific Antigen Elevation in the Context of Prostate Inflammation [PDF]

Urogenital Tract Infection
Prostate-specific antigen (PSA) is indispensable but not cancer specific; inflammation, benign prostatic hyperplasia, urinary retention, ejaculation, and instrumentation can all elevate PSA and complicate cancer risk assessment.
Byoungkyu Han, Ki-Hyuck Moon
doaj   +1 more source

Peripheral zone prostate-specific antigen density: an effective parameter for prostate cancer prediction in men receiving 5α-reductase inhibitors

Prostate International, 2013
To evaluate the predictive performance of various parameters derived from volume-adjusted prostate-specific antigen (PSA) values in detecting prostate cancer (PCa) and high-grade (Gleason score≥7) PCa according to treatment with a 5α-reductase inhibitor (
Kyo Chul Koo, Dong Hoon Lee, Seung Hwan Lee, Byung Ha Chung   +3 more
doaj   +1 more source

Correlation of Serum Gamma Glutamyl Transferase and Prostate Specific Antigen Level in Patients with Prostate Disorders

Pakistan Armed Forces Medical Journal
Objective: To correlate gamma-glutamyl transferase, prostate-specific antigen, and prostate-specific antigen density with ultrasound findings, including prostate-specific antigen volume and density, in patients with prostate disorders and to compare ...
Mehreen Aftab Khan, Ayesha Hafeez, Muhammad Younas, Syeda Binte Zahra Rizvi, Waqas Hanif, Syed Hurr   +5 more
doaj   +1 more source

CUT-OFF VALUES OF PROSTATE SPECIFIC ANTIGEN DENSITY– AN EFFECTIVE SCREENING MARKER BEFORE PROSTATE BIOPSY

Khyber Medical University Journal, 2022
OBJECTIVE: To determine cut-off values for prostate specific antigen density (PSAD) in diagnosing prostate carcinoma in symptomatic patients. METHODS: This cross sectional, observational study conducted at Department of Chemical Pathology and ...
Zujaja Hina Haroon, Qamar Bashir, Azka Haroon, Usama Bin Khalid   +3 more
doaj   +1 more source

The Impact of prostate – Specific Antigen Density In Predicting Prostate Cancer

Diyala Journal of Medicine, 2019
The objective of this study is to evaluate the impact of prostate-specific antigen density ( PSDA ) when serum levels of prostate-specific antigen ( PSA ) are less than 10 ng\ml in predicting prostate cancer. We retrospectively analyzed 134 patients who
Abdul-Kareem Sh. Al-Khafaji, Baha'a-Eladeen A. Al-Mujammaey   +1 more
doaj   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

AGE, TOTAL PSA, PSA DENSITY AND GLEASON SCORE, TAUS AS PREDICTIVE FACTORS IN PATIENTS WITH PROSTATE CANCER

Jurnal Urologi Indonesia, 2016
Objective: To find the factors related as predictive factors for Gleason score in prostate cancer patients. Material & methods: This study obtained a total sample of 144 patients with prostate cancer in Sardjito General Hospital Yogyakarta in 2009-2013 ...
Daruqutni Albar, Sungsang Rochadi
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Peripheral zone PSA density: a predominant variable to improve prostate cancer detection efficiency in men with PSA higher than 4 ng ml-1

Asian Journal of Andrology, 2021
To improve the diagnostic efficiency of prostate cancer (PCa) and reduce unnecessary biopsies, we defined and analyzed the diagnostic efficiency of peripheral zone prostate-specific antigen (PSA) density (PZ-PSAD).
Cheng Wang, Yue-Yang Wang, Shi-Yuan Wang, Ji-Xiang Ding, Mao Ding, Yuan Ruan, Xiao-Hai Wang, Yi-Feng Jing, Bang-Min Han, Shu-Jie Xia, Chen-Yi Jiang, Fu-Jun Zhao   +11 more
doaj   +1 more source