Results 31 to 40 of about 141,463 (194)

Peripheral zone prostate-specific antigen density: an effective parameter for prostate cancer prediction in men receiving 5α-reductase inhibitors

Prostate International, 2013
To evaluate the predictive performance of various parameters derived from volume-adjusted prostate-specific antigen (PSA) values in detecting prostate cancer (PCa) and high-grade (Gleason score≥7) PCa according to treatment with a 5α-reductase inhibitor (
Kyo Chul Koo, Dong Hoon Lee, Seung Hwan Lee, Byung Ha Chung   +3 more
doaj   +1 more source

Selective detection of histologically aggressive prostate cancer [PDF]

, 2012
BACKGROUND: Limited survival benefit and excess treatment because of prostate‐specific antigen (PSA) screening in randomized trials suggests a need for more restricted selection of prostate biopsy candidates by discerning risk of histologically ...
Andriole, Benson, Brassell, Bretton, Carroll, Carter, Carter, Cooperberg, Dall'Era, Dong, Ekwueme, Epstein, Epstein, Etzioni, Feliciano, Kapoor, Kattan, Kawachi, Klotz, Nam, Nam, Naya, Patel, Potosky, Roobol, Sanda, Schroder, Seaman, Steyerberg, Thompson, Warlick, Zietman   +31 more
core   +1 more source

Human prostate sphere-forming cells represent a subset of basal epithelial cells capable of glandular regeneration in vivo. [PDF]

, 2009
BackgroundProstate stem/progenitor cells function in glandular development and maintenance. They may be targets for tumor initiation, so characterization of these cells may have therapeutic implications.
Garraway, Isla P, Goldstein, Andrew S, Hahm, Scott A, Haider, Maahum, Head, Christian S, Perner, Sven, Reiter, Robert E, Rubin, Mark A, Sun, Wenyi, Tran, Chau P, Witte, Owen N, Zhang, Bao   +11 more
core   +1 more source

Advances in the design and development of oncolytic measles viruses. [PDF]

, 2015
A successful oncolytic virus is one that selectively propagates and destroys cancerous tissue without causing excessive damage to the normal surrounding tissue. Oncolytic measles virus (MV) is one such virus that exhibits this characteristic and thus has
Hutzen, Brian, Raffel, Corey, Studebaker, Adam W   +2 more
core   +1 more source

CUT-OFF VALUES OF PROSTATE SPECIFIC ANTIGEN DENSITY– AN EFFECTIVE SCREENING MARKER BEFORE PROSTATE BIOPSY

Khyber Medical University Journal, 2022
OBJECTIVE: To determine cut-off values for prostate specific antigen density (PSAD) in diagnosing prostate carcinoma in symptomatic patients. METHODS: This cross sectional, observational study conducted at Department of Chemical Pathology and ...
Zujaja Hina Haroon, Qamar Bashir, Azka Haroon, Usama Bin Khalid   +3 more
doaj   +1 more source

Trop2 and its overexpression in cancers: regulation and clinical/therapeutic implications. [PDF]

, 2014
Trop2 is a transmembrane glycoprotein encoded by the Tacstd2 gene. It is an intracellular calcium signal transducer that is differentially expressed in many cancers. It signals cells for self-renewal, proliferation, invasion, and survival.
Bonavida, Benjamin, Shvartsur, Anna
core   +5 more sources

AGE, TOTAL PSA, PSA DENSITY AND GLEASON SCORE, TAUS AS PREDICTIVE FACTORS IN PATIENTS WITH PROSTATE CANCER

Jurnal Urologi Indonesia, 2016
Objective: To find the factors related as predictive factors for Gleason score in prostate cancer patients. Material & methods: This study obtained a total sample of 144 patients with prostate cancer in Sardjito General Hospital Yogyakarta in 2009-2013 ...
Daruqutni Albar, Sungsang Rochadi
doaj   +1 more source

Peripheral zone PSA density: a predominant variable to improve prostate cancer detection efficiency in men with PSA higher than 4 ng ml-1

Asian Journal of Andrology, 2021
To improve the diagnostic efficiency of prostate cancer (PCa) and reduce unnecessary biopsies, we defined and analyzed the diagnostic efficiency of peripheral zone prostate-specific antigen (PSA) density (PZ-PSAD).
Cheng Wang, Yue-Yang Wang, Shi-Yuan Wang, Ji-Xiang Ding, Mao Ding, Yuan Ruan, Xiao-Hai Wang, Yi-Feng Jing, Bang-Min Han, Shu-Jie Xia, Chen-Yi Jiang, Fu-Jun Zhao   +11 more
doaj   +1 more source

The Impact of prostate – Specific Antigen Density In Predicting Prostate Cancer

Diyala Journal of Medicine, 2019
The objective of this study is to evaluate the impact of prostate-specific antigen density ( PSDA ) when serum levels of prostate-specific antigen ( PSA ) are less than 10 ng\ml in predicting prostate cancer. We retrospectively analyzed 134 patients who
Abdul-Kareem Sh. Al-Khafaji, Baha'a-Eladeen A. Al-Mujammaey   +1 more
doaj   +2 more sources

Targeting advanced prostate cancer with STEAP1 chimeric antigen receptor T cell and tumor-localized IL-12 immunotherapy

Nature Communications, 2023
Six transmembrane epithelial antigen of the prostate 1 (STEAP1) is a cell surface antigen for therapeutic targeting in prostate cancer. Here, we report broad expression of STEAP1 relative to prostate-specific membrane antigen (PSMA) in lethal metastatic ...
Vipul Bhatia, Nikhil V. Kamat, Tiffany E. Pariva, Li-Ting Wu, Annabelle Tsao, Koichi Sasaki, Huiyun Sun, Gerardo Javier, Sam Nutt, Ilsa Coleman, Lauren Hitchcock, Ailin Zhang, Dmytro Rudoy, Roman Gulati, Radhika A. Patel, Martine P. Roudier, Lawrence D. True, Shivani Srivastava, Colm M. Morrissey, Michael C. Haffner, Peter S. Nelson, Saul J. Priceman, Jun Ishihara, John K. Lee   +23 more
doaj   +1 more source