Results 91 to 100 of about 1,302,201 (345)

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity

FEBS Open Bio, EarlyView.
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda, Melissa Montrose, Akinori Takahashi, Risa Ishida, Sandrine Burriel, Nao Ohmine, Tohru Natsume, Shungo Adachi, Minsoo Kim, Tadashi Yamamoto   +9 more
wiley   +1 more source

Clonal hematopoiesis in metastatic urothelial and renal cell carcinoma

npj Precision Oncology
Clonal hematopoiesis (CH) is an age-related expansion of white blood cell (WBC) progenitors linked to risk of hematological malignancy. Patients with cancer have increased CH prevalence compared to healthy populations, but the characteristics and ...
Aslı D. Munzur, Jack V. W. Bacon, Francine Fishbein, Cameron Herberts, Gráinne Donnellan, Cecily Q. Bernales, Karan Parekh, Gillian Vandekerkhove, David C. Müller, Yi Jou Ruby Liao, Maria Stephenson, Lucia Nappi, Daniel Khalaf, Corinne Maurice-Dror, Kim N. Chi, Bernhard J. Eigl, Christian Kollmannsberger, Maryam Soleimani, Alexander W. Wyatt   +18 more
doaj   +1 more source

Computer-Aided Discovery of Small Molecules Targeting the RNA Splicing Activity of hnRNP A1 in Castration-Resistant Prostate Cancer

Molecules, 2019
The heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is a versatile RNA-binding protein playing a critical role in alternative pre-mRNA splicing regulation in cancer.
Lavinia A. Carabet, Eric Leblanc, Nada Lallous, Helene Morin, Fariba Ghaidi, Joseph Lee, Paul S. Rennie, Artem Cherkasov   +7 more
doaj   +1 more source

The long tail of oncogenic drivers in prostate cancer

Nature Genetics, 2018
Comprehensive genomic characterization of prostate cancer has identified recurrent alterations in genes involved in androgen signaling, DNA repair, and PI3K signaling, among others.
J. Armenia, Stephanie A. M. Wankowicz, David Liu, Jianjiong Gao, Ritika Kundra, Ed Reznik, W. Chatila, D. Chakravarty, G. Han, Ilsa M Coleman, B. Montgomery, C. Pritchard, C. Morrissey, C. Barbieri, H. Beltran, A. Sboner, Z. Zafeiriou, S. Miranda, C. Bielski, A. Penson, C. Tolonen, F. Huang, D. Robinson, Yi Mi Wu, R. Lonigro, L. Garraway, F. Demichelis, P. Kantoff, M. Taplin, W. Abida, B. Taylor, H. Scher, P. Nelson, J. Bono, M. Rubin, C. Sawyers, A. Chinnaiyan, N. Schultz, E. V. Van Allen, PCFSU2C International Prostate Cancer Dream Team   +39 more
semanticscholar   +1 more source

Prostate Cancer [PDF]

The Scientific World JOURNAL, 2011
Prostate cancer continues to be a significant public health issue worldwide, particularly in countries where men have life expectancies long enough to clinically manifest the disease. In many countries, it remains one of the leading causes of cancer-related morbidity and mortality.Although significant progress has been made over the past few decades ...
openaire   +3 more sources

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Genetics and biology of prostate cancer

Genes & Development, 2018
Here, Wang et al. review available prostate cancer model systems, the prostate cancer genome atlas, cellular and functional heterogeneity in the tumor microenvironment, tumor-intrinsic and tumor-extrinsic mechanisms underlying therapeutic resistance, and
Guocan Wang, Di Zhao, D. Spring, R. DePinho   +3 more
semanticscholar   +1 more source

High LRIG1 expression predicts lymph node metastasis in patients with uterine cervical cancer

FEBS Open Bio, EarlyView.
Lymph node status is crucial in determining treatment for women with early‐stage cervical cancer. We demonstrate that high LRIG1 protein expression in primary tumors can predict lymph node metastases. Our findings support further investigation of LRIG1 as a biomarker to improve staging accuracy and guide treatment decisions in cervical cancer patients.
Pernilla Israelsson, Lisa Lif, Husam Oda, Alexandra Lorenzzi de Melo, David Lindquist, Håkan Hedman   +5 more
wiley   +1 more source

Electrical pulse stimulation reflecting the episodic nature of real‐life exercise modulates metabolic and secretory profile of primary human myotubes

FEBS Open Bio, EarlyView.
Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová, Tímea Kurdiová, Daria Barkova, Natália Pálešová, Jana Babulicová, Silvia Tyčiaková, Marta Novotová, Mária Balážová, Miroslav Sabo, Václav Pustka, Jozef Ukropec, Barbara Ukropcová   +11 more
wiley   +1 more source

Evaluating different methods for kidney recellularization

Scientific Reports
This study explores a potential solution to the shortage of kidneys for transplantation in end-stage renal disease (ESRD). Currently, kidney transplantation stands as the optimal option, yet the scarcity of organs persists.
Ana C. Luque-Badillo, Cesar U. Monjaras-Avila, Hans Adomat, Alan So, Claudia Chavez-Muñoz   +4 more
doaj   +1 more source