Results 101 to 110 of about 1,482,586 (339)

Racial/Ethnic Patterns in Prostate Cancer Outcomes in an Active Surveillance Cohort

Prostate Cancer, 2011
Introduction. Concern regarding overtreatment of prostate cancer (CaP) is leading to increased attention on active surveillance (AS). This study examined CaP survivors on AS and compared secondary treatment patterns and overall survival by race/ethnicity.
Jennifer Cullen, Stephen A. Brassell, Yongmei Chen, Christopher Porter, James L'Esperance, Timothy Brand, David G. McLeod   +6 more
doaj   +1 more source

Exosomal αvβ6 integrin is required for monocyte M2 polarization in prostate cancer [PDF]

, 2018
Therapeutic approaches aimed at curing prostate cancer are only partially successful given the occurrence of highly metastatic resistant phenotypes that frequently develop in response to therapies.
Altieri, Dario C., Bowler, Nicholas, Craig Hooper, D., Dutta, Anindita, Ertel, Adam, Fedele, Carmine, Forsberg, Flemming, Fortina, Paolo, Gabrilovich, Dmitry I., Harshyne, Larry A., Kean, Rhonda B., Kelly, William K., Kossenkov, Andrew V., Krishn, Shiv Ram, Kurtoglu, Senem, Languino, Lucia R., Liu, Qin, Lu, Huimin, Speicher, David W., Stanczak, Maria, Tang, Hsin-Yao, Wang, Kerith, Weinreb, Paul H., Yu, Lei   +23 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Editorial Comment to Safety and efficacy of apalutamide in Japanese patients with metastatic castration‐sensitive prostate cancer receiving androgen deprivation therapy: Final report for the Japanese subpopulation analysis of the randomized, placebo‐controlled, phase III TITAN study

, 2022
Zhijiang Zang, Ziting Wang, Edmund Chiong   +2 more
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Prostate cancer screening: well intentioned initiatives may use up resources but not improve health outcomes

, 2023
Sonya H Bushell, David Spitzer, Phil Whittaker, Avril Nexus, Neal Maskrey, Maggie Helliway, Nick Price, Lindsey Pope, Clare Etherington, James Larcombe, Julie Grigg, Susan Bewley, David Taylor   +12 more
openalex   +2 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Evaluating different methods for kidney recellularization

Scientific Reports
This study explores a potential solution to the shortage of kidneys for transplantation in end-stage renal disease (ESRD). Currently, kidney transplantation stands as the optimal option, yet the scarcity of organs persists.
Ana C. Luque-Badillo, Cesar U. Monjaras-Avila, Hans Adomat, Alan So, Claudia Chavez-Muñoz   +4 more
doaj   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Clonal hematopoiesis in metastatic urothelial and renal cell carcinoma

npj Precision Oncology
Clonal hematopoiesis (CH) is an age-related expansion of white blood cell (WBC) progenitors linked to risk of hematological malignancy. Patients with cancer have increased CH prevalence compared to healthy populations, but the characteristics and ...
Aslı D. Munzur, Jack V. W. Bacon, Francine Fishbein, Cameron Herberts, Gráinne Donnellan, Cecily Q. Bernales, Karan Parekh, Gillian Vandekerkhove, David C. Müller, Yi Jou Ruby Liao, Maria Stephenson, Lucia Nappi, Daniel Khalaf, Corinne Maurice-Dror, Kim N. Chi, Bernhard J. Eigl, Christian Kollmannsberger, Maryam Soleimani, Alexander W. Wyatt   +18 more
doaj   +1 more source