Results 41 to 50 of about 1,247,684 (370)

A microsatellite repeat in PCA3 long non-coding RNA is associated with prostate cancer risk and aggressiveness

Scientific Reports, 2017
Short tandem repeats (STRs) are repetitive sequences of a polymorphic stretch of two to six nucleotides. We hypothesized that STRs are associated with prostate cancer development and/or progression. We undertook RNA sequencing analysis of prostate tumors
John Lai, Leire Moya, Jiyuan An, Andrea Hoffman, Srilakshmi Srinivasan, Janaththani Panchadsaram, Carina Walpole, Joanna L. Perry-Keene, Suzanne Chambers, Australian Prostate Cancer BioResource, Melanie L. Lehman, Colleen C. Nelson, Judith A. Clements, Jyotsna Batra   +13 more
doaj   +1 more source

Abiraterone for Prostate Cancer Not Previously Treated with Hormone Therapy

New England Journal of Medicine, 2017
Background Abiraterone acetate plus prednisolone improves survival in men with relapsed prostate cancer. We assessed the effect of this combination in men starting long‐term androgen‐deprivation therapy (ADT), using a multigroup, multistage trial design.
N. James, J. D. de Bono, M. Spears, N. Clarke, M. Mason, D. Dearnaley, A. Ritchie, C. Amos, C. Gilson, Robert J. Jones, D. Matheson, R. Millman, G. Attard, S. Chowdhury, W. Cross, S. Gillessen, C. Parker, M. Russell, D. Berthold, C. Brawley, F. Adab, San Aung, A. Birtle, J. Bowen, S. Brock, P. Chakraborti, C. Ferguson, J. Gale, E. Gray, M. Hingorani, P. Hoskin, J. Lester, Z. Malik, F. McKinna, N. McPhail, J. Money-Kyrle, J. O’Sullivan, O. Parikh, A. Protheroe, A. Robinson, N. Srihari, Carys W Thomas, J. Wagstaff, J. Wylie, A. Zarkar, M. Parmar, M. Sydes   +46 more
semanticscholar   +1 more source

Improvement of quality of life and symptom burden after robot-assisted radical prostatectomy in patients with moderate to severe LUTS

Scientific Reports, 2021
The aim of this study was to assess clinically meaningful differences of preoperative lower urinary tract symptoms (LUTS) and quality of life (QoL) before and after robot-assisted radical prostatectomy (RARP).
Sami-Ramzi Leyh-Bannurah, Christian Wagner, Andreas Schuette, Nikolaos Liakos, Theodoros Karagiotis, Mikolaj Mendrek, Pawel Rachubinski, Katarina Urbanova, Matthias Oelke, Jorn H. Witt   +9 more
doaj   +1 more source

Dosimetric and Deformation Effects of Image-Guided Interventions during Stereotactic Body Radiation Therapy of the Prostate using an Endorectal Balloon [PDF]

Medical Physics 39, 3080 (2012), 2013
During Stereotactic Body Radiotherapy (SBRT) for the treatment of prostate cancer, an inflatable endorectal balloon (ERB) may be used to reduce motion of the target and reduce the dose to the posterior rectal wall. This work assessed the dosimetric impact of manual interventions on ERB position in patients receiving prostate SBRT and investigated the ...
arxiv   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Feasibility of radical cardiac‐sparing, treatment planning strategies for patients with locally advanced, non‐small cell lung cancer

Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract Purpose A set of treatment planning strategies were designed and retrospectively implemented for locally advanced, non‐small cell lung cancer (NSCLC) patients in order to minimize cardiac dose without compromising target coverage goals. Methods Retrospective analysis was performed for 20 NSCLC patients prescribed to 60–66 Gy that received a ...
Joshua P. Kim, Jake Dewalt, Aharon Feldman, Khaled Adil, Benjamin Movsas, Indrin J. Chetty   +5 more
wiley   +1 more source

Evaluating whether Prostate Cancer UK’s risk checker is a help or hindrance to prostate-specific antigen testing policy: a mixed-methods study

BJGP Open
Background: The UK has an informed choice testing policy for prostate cancer. The prostate-specific antigen (PSA) blood test is available for free to any man aged ≥50 years who requests it and has been informed of the harms and benefits.
Natalia Norori, Chiara de Biase, Yui Hang Wong, Sadie Robson Crabtree, Matt Cox, Esther Appleby, Andrew Seggie, Rachel Brown, Amy Rylance   +8 more
doaj   +1 more source

Enzalutamide in metastatic prostate cancer before chemotherapy.

New England Journal of Medicine, 2014
BACKGROUND Enzalutamide is an oral androgen-receptor inhibitor that prolongs survival in men with metastatic castration-resistant prostate cancer in whom the disease has progressed after chemotherapy.
T. Beer, A. Armstrong, D. Rathkopf, Y. Loriot, Cora N. Sternberg, C. Higano, P. Iversen, S. Bhattacharya, J. Carles, S. Chowdhury, Ian D. Davis, J. D. de Bono, Christopher P Evans, K. Fizazi, Anthony M. Joshua, Choung-Soo Kim, G. Kimura, P. Mainwaring, H. Mansbach, K. Miller, S. Noonberg, F. Perabo, D. Phung, F. Saad, H. Scher, M. Taplin, P. Venner, B. Tombal   +27 more
semanticscholar   +1 more source

Flow‐based immunomagnetic enrichment of circulating tumor cells from diagnostic leukapheresis product

Molecular Oncology, EarlyView.
The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens, Anouk Mentink, Frank A. W. Coumans, Eshwari Dathathri, Khrystany T. Isebia, Jaco Kraan, Ronald de Wit, John W. M. Martens, Leon W. M. M. Terstappen   +8 more
wiley   +1 more source

A small footprint couch‐top support device for image‐guided radiotherapy of heavy patients

Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract Purpose Patients with body weights close to or above 400 lbs present unique challenges in radiation therapy since the weight limit of most treatment couches decreases as the couch‐top extends toward the treatment gantry. The purpose of this work was to develop a small footprint couch‐top support platform to safely perform image‐guided ...
Huixiao Chen, Kevin Morley, Ronnie Rodriguez, Emily Draeger, Muhammad Shafiq ul Hassan, Zhe (Jay) Chen   +5 more
wiley   +1 more source