Results 111 to 120 of about 576,362 (247)

Plateau effect of prostate cancer risk‐associated SNPs in discriminating prostate biopsy outcomes

, 2013
BACKGROUND Additional prostate cancer (PCa) risk-associated single nucleotide polymorphisms (SNPs) continue to be identified. It is unclear whether addition of newly identified SNPs improves the discriminative performance of biopsy outcomes over ...
Shancheng Ren, Jianfeng Xu, Yinghao Sun, Wu, Yishuo, Bo Yang, Na, Rong, Zheng, S. Lilly, Haowen Jiang, Fang Liu, Haitao Chen, Gao, Xu, Xu Gao, Xu, Jianfeng, S. Lilly Zheng, Sun, Jielin, Liu, Fang, Ding, Qiang, Ren, Shancheng, Sun, Yinghao, Jiang, Haowen, Qiang Ding, Zhang, Limin, Xu, Chuanliang, Limin Zhang, Yishuo Wu, Tie Zhou, Zhou, Tie, Yang, Bo, Jielin Sun, Chuanliang Xu, Rong Na, Chen, Haitao   +31 more
core   +1 more source

Living at genetic risk: The patient experience of Lynch syndrome

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome is a germline cancer predisposition syndrome caused by a variant in one of four genes. Lynch syndrome places individuals at significantly higher risk for a range of cancers, especially colorectal and endometrial. Depending on which gene is affected, the risk of ovarian, gastric, small bowel, pancreatic, biliary urothelial, brain,
Nicola Reents, Georgina Hoffmann, Kelly Kohut   +2 more
wiley   +1 more source

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source

Epigenetic Dysregulation of Somatostatin Receptors (SSTR) 1–5 and Therapeutic Implications in Neuroendocrine and Non‐Neuroendocrine Malignancies

International Journal of Cancer, EarlyView.
ABSTRACT Somatostatin receptors (SSTR) mediate the antiproliferative, antisecretory, and proapoptotic effects of somatostatin and its synthetic analogs. Their surface expression on neuroendocrine tumor (NET) cells is required for somatostatin analog therapy and radiopharmaceutical therapy (RPT).
Neeraj Kumari, Pablo Hoffmann, Laura Reichl, Maximilian Schmutz, Nina Fischer, Thi Tuong Vi Dang, Fulvia Ferrazzi, Pascal Johann, Michaela Kuhlen, Constantin Lapa, Rainer Claus   +10 more
wiley   +1 more source

To investigate using morphometric and immunohistochemical criteria the relationship between prostatic intra-epithelial neoplasia and prostate cancer. [PDF]

, 2006
Prostatic Intraepithelial Neoplasia (PIN) is a putatitive precursor of prostate carcinoma (CaP). PIN is defined as an abnormal proliferation where the cellular changes exhibit the cytological changes of cancer, but retain a basal cell layer.
Sandhu, Sarbjinder Singh, Sandhu, S.S.
core  

Performance of serum prostate-specific antigen isoform [-2]proPSA (p2PSA) and the prostate health index (PHI) in a Chinese hospital-based biopsy population

, 2014
BACKGROUND. The use of serum [-2]proPSA (p2PSA) and its derivative, the prostate health index (PHI), in detecting prostate cancer (PCa) have been consistently shown to have better performance than total prostate-specific antigen (tPSA) in discriminating ...
Ding, Qiang, Wu, Yishuo, Ren, Shancheng, Sun, Yinghao, Jiang, Haowen, Wang, Meilin, Zhang, Guiming, Na, Rong, Ye, Dingwei, Zheng, S. Lilly, Yu, Guopeng, Qi, Jun, Zhu, Yao, Xu, Jianfeng, Chen, Haitao, Sun, Jielin, Wang, Wenying, Liu, Fang   +17 more
core   +1 more source

The Association Between Human Papillomavirus and Prostate Cancer: A Systematic Review and Meta‐Analysis

International Journal of Cancer, EarlyView.
ABSTRACT Human papillomavirus (HPV), the necessary cause of cervical cancer, is associated with an increased risk of other anogenital cancers. While HPV has frequently been detected in prostate specimens, its role in prostate carcinogenesis remains controversial. We synthesized and meta‐analyzed the epidemiological literature on the association between
Sarah Botting‐Provost, Kristy Ng, Cassandra Laurie, Rodrigo Noorani, Mariam El‐Zein, Eduardo L. Franco   +5 more
wiley   +1 more source

Clinical Translation of Patient‐Derived Organoids: Perspectives for Personalized Therapy in Cancer

International Journal of Cancer, EarlyView.
ABSTRACT Patient‐derived organoids (PDO) are accelerating precision medicine. These biological platforms allow for the autologous in vitro expansion of material from cancer patients in a considerably short period of time. These three‐dimensional models can faithfully recapitulate aspects of tissue heterogeneity, architecture, and relevant cellular ...
Haiyan Yue, Daniele Carchidi, Philipp Schmucker, Roland Seiler, Bernhard Kiss, Catarina Macedo‐Silva, Marianna Kruithof‐de Julio   +6 more
wiley   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source