Results 81 to 90 of about 105,659 (312)

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Correlation of Transrectal Ultrasonography Guided Prostate Biopsy Gleason Score Results with Prostate Volume in Patients with Prostate Specific Antigen Level Between 2.5-10 ng/mL [PDF]

Objective: To investigate the correlation between prostate volume (PV) and Gleason score (GS) results obtained by systematic transrectal prostate biopsy in patients with a prostate-specific antigen value between 2.5 and 10 ng/mL.
Kazım Erdem, Coşkun Bostancı
core   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

Non-infectious complications following transrectal prostate needle biopsy – Outcomes from over 8000 procedures

, 2022
BACKGROUND: Prostate needle biopsy (PNB) remains the referent standard for diagnosing prostate cancer. Contemporary data highlight an increase in PNB-related infections particularly when performed transrectally. Non-infectious complications, however, may
Kaynaat Syed, Eric A. Singer, Thomas Guzzo, Claudette Fonshell, Gregory Diorio, Jacobs, Bruce, Guzzo, Thomas, Reese, Adam, John Danella, Singer, Eric A., Jay D. Raman, Owens, Russell G., Raman, Jay D., Adrian Sosenko, Fonshell, Claudette, Diorio, Gregory, Tomaszewski, Jeffrey, Adam Reese, Danella, John, Sosenko, Adrian, Ae Lim Yang, Serge Ginzburg, Syed, Kaynaat, Smaldone, Marc, Ahmad Alzubaidi, Yang, Ae Lim, Russell G. Owens, Ginzburg, Serge, Alzubaidi, Ahmad, Marc Smaldone, Trabulsi, Edouard, Jeffrey Tomaszewski, Bruce Jacobs, Edouard Trabulsi   +33 more
core   +1 more source

A Bioinspired Three‐Dimensional High‐Curvature Nano‐Interface Integrated Microfluidic Chip for Small Extracellular Vesicles Enrichment and Machine Learning‐Assisted Prostate Cancer Precision Diagnosis

Advanced Science, EarlyView.
A biotin‐modified artificial insertion peptide functionalized three‐dimensional high‐curvature‐TiO2 nano‐interface was engineered in a microfluidic chip to improve the isolation efficiency of small extracellular vesicles (sEVs). This chip balanced affinity, releasability, and extendibility, enabling high‐throughput recovery of sEVs for downstream ...
Le Wang, Yizhong Liang, Manan Sulaiman, Jiaqi Du, Ming Jiang, Zhihua Wang, Xu Yu, Li Xu   +7 more
wiley   +1 more source

Роль и значение мультипараметрической магнитно-резонансной томографии в диагностике рака предстательной железы

, 2017
The problem of timely diagnosis and malignancy grade evaluation of prostate cancer is especially urgent considering continuous and progredient increase in morbidity and mortality caused by this nosology, as well as difficulty of diagnostics.
I. E. Turin, Б. Ш. Камолов, Ю. В. Буйденок, В. Б. Матвеев, B. Sh. Kamolov, G. I. Akhverdieva, И. И. Абдуллин, В. О. Панов, V. B. Matveev, V. A. Chernyaev, V. O. Panov, Yu. V. Buydenok, В. А. Черняев, И. Е. Тюрин, Ph. A. Kossov, I. I. Abdullin, Ф. А. Коссов, Г. И. Ахвердиева   +17 more
core   +1 more source

MRI-guided biopsy of the prostate: correlation between the cancer detection rate and the number of previous negative TRUS biopsies [PDF]

, 2013
PURPOSEWe aimed to investigate prostate cancer detection rate of magnetic resonance imaging (MRI)-guided biopsy and to elucidate possible relations to the number of prior negative transrectal ultrasonography (TRUS)-guided biopsies.MATERIALS AND ...
Alexander Huppertz,, Bernd Hamm,, Uta Reichelt,, Dirk Beyersdorff,, Tahir Durmuş,, Tobias Franiel   +5 more
core   +1 more source

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

SERS Facemask for Rapid and Portable Sensing Mycobacterium Tuberculosis Antigens for TB Screening

Advanced Science, EarlyView.
Our study introduced an Au─Ag embedded covalent organic framework (U@COF) ‐mediated facemask for sensing TB antigen ESAT‐6/CFP‐10 complex in clinical droplet samples toward TB screening. Practical analysis of clinical samples demonstrated the availability of our facemask, which is capable of identifying the TB subjects (N = 17) from healthy candidates (
Lingzhi Chen, Jiaqi Yu, Jing Xu, Lingqi Chen, Ninghao Zhang, Wenrui Li, Runmin Zeng, Xiaomin Luo, Yiqun Chang, Jiayin Lai, Wenshi Huang, Xiaochen Liang, Ting Zhao, Shanze Chen, Huaihong Cai, Yanguang Cong, Pinghua Sun, Jiang Pi, Xueqin Huang, Haibo Zhou, Junxia Zheng   +20 more
wiley   +1 more source

Toward Prostate Cancer Early Warning with a Self‐Powered Wearable Biosensing Platform Integrated with Machine Learning

Advanced Science, EarlyView.
ABSTRACT Current prostate cancer detection methods remain limited in non‐invasiveness and specificity, prompting interest in urinary biomarkers such as sarcosine. Here, we report a urine‐powered wearable platform for non‐invasive sarcosine detection as a proof‐of‐concept for decentralized early warning.
Jing Xu, Hanxiao Chen, Qichen Yuan, Liucun Yin, Yifang Tao, Hong Wang, Yuquan Xue, Delai Fu, Huan Pang, Tie Chong, Li Xue   +10 more
wiley   +1 more source