Results 61 to 70 of about 5,889,184 (390)

Prostate Cancer, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology.

The Journal of the National Comprehensive Cancer Network, 2019
The NCCN Guidelines for Prostate Cancer include recommendations regarding diagnosis, risk stratification and workup, treatment options for localized disease, and management of recurrent and advanced disease for clinicians who treat patients with prostate
J. Mohler, E. Antonarakis, A. Armstrong, A. D'Amico, B. Davis, T. Dorff, J. Eastham, C. Enke, T. Farrington, C. Higano, E. Horwitz, M. Hurwitz, J. Ippolito, C. Kane, M. Kuettel, J. Lang, J. McKenney, G. Netto, D. Penson, E. Plimack, J. Pow-Sang, T. Pugh, Sylvia S. Richey, M. Roach, Stan Rosenfeld, E. Schaeffer, A. Shabsigh, E. Small, D. Spratt, S. Srinivas, J. Tward, Dorothy Shead, Deborah A. Freedman-Cass   +32 more
semanticscholar   +1 more source

Outcomes of Observation vs Stereotactic Ablative Radiation for Oligometastatic Prostate Cancer

JAMA Oncology, 2020
This randomized clinical trial assesses whether treatment with stereotactic ablative radiotherapy vs observation improves oncologic outcomes in men with recurrent hormone-sensitive oligometastatic prostate cancer.
R. Phillips, W. Shi, M. Deek, N. Radwan, S. Lim, E. Antonarakis, S. Rowe, A. Ross, M. Gorin, C. Deville, S. Greco, Hailun Wang, S. Denmeade, C. Paller, S. Dipasquale, T. DeWeese, D. Song, Hao Wang, M. Carducci, K. Pienta, M. Pomper, A. Dicker, M. Eisenberger, Ash A. Alizadeh, M. Diehn, P. Tran   +25 more
semanticscholar   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Is birthweight associated with total and aggressive/lethal prostate cancer risks? A systematic review and meta-analysis [PDF]

, 2016
BACKGROUND: It has been hypothesised that intrauterine exposures are important for subsequent prostate cancer risk. Prior epidemiological studies have used birthweight as a proxy of cumulative intrauterine exposures to test this hypothesis, but results ...
Cook, Michael B, Hardy, Rebecca, Kuh, Diana, Mackinnon, Karen, Sutcliffe, Siobhan, Welsh, Judith, Zhou, Cindy Ke   +6 more
core   +3 more sources

MRI-Targeted, Systematic, and Combined Biopsy for Prostate Cancer Diagnosis.

New England Journal of Medicine, 2020
BACKGROUND The use of 12-core systematic prostate biopsy is associated with diagnostic inaccuracy that contributes to both overdiagnosis and underdiagnosis of prostate cancer.
M. Ahdoot, Andrew R Wilbur, Sarah E Reese, A. Lebastchi, Sherif Mehralivand, Patrick T. Gomella, Jonathan B Bloom, Sandeep Gurram, M. Siddiqui, P. Pinsky, H. Parnes, W. Linehan, M. Merino, P. Choyke, J. Shih, B. Turkbey, B. Wood, P. Pinto   +17 more
semanticscholar   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology

Nature Communications, 2021
The prognosis of castration-resistant prostate cancers remains dismal, but accurate preclinical models can lead to effective therapies. Here the Melbourne Urological Research Alliance establish prostate cancer patient-derived xenografts, use the tumors ...
Gail P. Risbridger, Ashlee K. Clark, Laura H. Porter, Roxanne Toivanen, Andrew Bakshi, Natalie L. Lister, David Pook, Carmel J. Pezaro, Shahneen Sandhu, Shivakumar Keerthikumar, Rosalia Quezada Urban, Melissa Papargiris, Jenna Kraska, Heather B. Madsen, Hong Wang, Michelle G. Richards, Birunthi Niranjan, Samantha O’Dea, Linda Teng, William Wheelahan, Zhuoer Li, Nicholas Choo, John F. Ouyang, Heather Thorne, Lisa Devereux, Rodney J. Hicks, Shomik Sengupta, Laurence Harewood, Mahesh Iddawala, Arun A. Azad, Jeremy Goad, Jeremy Grummet, John Kourambas, Edmond M. Kwan, Daniel Moon, Declan G. Murphy, John Pedersen, David Clouston, Sam Norden, Andrew Ryan, Luc Furic, David L. Goode, Mark Frydenberg, Mitchell G. Lawrence, Renea A. Taylor   +44 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Tyrol Prostate Cancer Demonstration Project : early detection, treatment, outcome, incidence and mortality [PDF]

, 2008
This study aimed to evaluate the effectiveness of a well-controlled programme of early detection and treatment of prostate cancer in the population of Tyrol, Austria, where such a programme of early detection and treatment was initiated in 1988 and where
Bartsch, Georg, Bektic, Jasmin, Boniol, Mathieu, Boyle, Peter, Frauscher, Ferdinand, Horninger, Wolfgang, Klocker, Helmut, Oberaigner, Wilhelm, Pelzer, Alexandre, Robertson, Chris, Schafer, Georg, Schennach, Harald, Severi, Gianluca, Tyrol Prostate Canc Screening Grp   +13 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source