Results 201 to 210 of about 9,980,667 (237)

Harnessing Aggregation‐Induced Emission for Advanced Disease Diagnosis: Mechanisms, Strategies and Future Perspectives

Medicine Bulletin, EarlyView.
The figure was created in BioRender.com. ABSTRACT Accurate and early diagnosis remains a key challenge in modern disease management. Conventional diagnostic methods often suffer from limitations in sensitivity, spatial resolution, and practical usability.
Zizhuo Du, Li Song, Xingrui Chen, Jun Jing, Yingchen Wang, Yue Jiang, Jiahui Gao, Dan Li, Feiran Xie, Peihong Xiao, Ben Zhong Tang   +10 more
wiley   +1 more source

Evaluation of Cutoff Point Prostate Specific Antigen (PSA) and Prostate Specific Antigen Density (PSAD) in Patients with Suspected Prostate Cancer. [PDF]

Med Arch
Daryanto B, Trianto R, Seputra KP, Purnomo AF.   +3 more
europepmc   +1 more source

Dedifferentiation in endometrial cancer is associated with HLA‐I silencing that may be restored by IFN‐γ

The Journal of Pathology, EarlyView.
Abstract Dedifferentiated endometrial carcinoma occurs when a prognostically favorable low‐grade endometrial carcinoma transforms into a highly aggressive undifferentiated carcinoma following genomic inactivation of core SWItch/Sucrose Non‐Fermentable (SWI/SNF) complex protein(s).
Antonio De Leo, Madison Wickenberg, Marco Grillini, Camelia Alexandra Coadǎ, Pooja Praveen Kumar, Annie Tong, James Key, Hannah Kim, Felix Kommoss, Mark Carey, Yangxin Fu, Claudio Ceccarelli, Giovanni Tallini, Paul LaPointe, Martin Köbel, Cheng‐Han Lee   +15 more
wiley   +1 more source

Epigenetic Regulation of Liver Fibrosis: Mechanisms and Therapeutic Implications

Portal Hypertension &Cirrhosis, EarlyView.
This review synthesizes the epigenetic mechanisms—DNA methylation, histone modifications, and non‐coding RNAs—that drive hepatic stellate cell activation and the progression of liver fibrosis. It further evaluates emerging therapeutic strategies targeting these epigenetic regulators, including DNA methyltransferase and histone deacetylase inhibitors ...
Maryam Jadid Tavaf, Mahboobeh Ebrahimi Varkiani, Saeid Abroun, Pedram Asadi‐Sarabi, Shukoofeh Torabi, Elham Rismani, Mohammad Majd Hammour, Andreas K. Nüssler, Massoud Vosough   +8 more
wiley   +1 more source

Precision in prostate cancer detection: integrating prostate-specific antigen density (PSAD) and the Prostate Imaging Reporting and Data System (PI-RADS) to provide additional risk stratification for a more accurate diagnostic decision. [PDF]

Ir J Med Sci
Hrubá T, Kubas V, Franko M, Baláž V, Spurný M, Mištinová JP.   +5 more
europepmc   +1 more source

Primary BPH Stromal Cell Cultures Exhibit Heightened Androgen‐Responsiveness

The Prostate, EarlyView.
ABSTRACT Background Benign prostatic hyperplasia (BPH) is the most common disease in aging males. BPH growth is androgen‐dependent, and it appears that androgens preferentially stimulate the growth of BPH as compared to normal prostate. The mechanism of preferential androgen stimulation of BPH growth is not clear.
Wei Chen, Fulu Dong, Mohammad Reza Askarpour, Laura E. Pascal, Rajiv Dhir, Uma Chandran, Bruce L. Jacobs, Donald B. DeFranco, Naoki Yoshimura, Zhou Wang   +9 more
wiley   +1 more source

Natural History of PI‐RADS 3 Lesions on Serial Prostate mpMRI

The Prostate, EarlyView.
ABSTRACT Objective PI‐RADS 3 lesions on prostate multiparametric MRI (mpMRI) are indeterminate findings with debated management. We evaluated their radiologic evolution on follow‐up mpMRI and correlated imaging changes with biopsy outcomes. Methods We retrospectively identified 166 men with at least one PI‐RADS 3 lesion on initial mpMRI and at least ...
Tomer Bashi, Yanai Rubinstein, Adi Kidron, Ron Marom, Yuval Rand, Meitar Atias, Sophie Barnes, Ibrahim Fahoum, Gal Keren‐Paz, Mario Sofer, Ofer Yossepowitch, Snir Dekalo, Avi Beri, Roy Mano   +13 more
wiley   +1 more source

Prognostic Value of MRI‐Derived Apparent Diffusion Coefficient in Intermediate‐Risk Prostate Cancer Treated With Definitive Radiotherapy

The Prostate, EarlyView.
ABSTRACT Background Intermediate‐risk prostate cancer (IR‐PCa) is a heterogeneous disease with variable clinical outcomes despite established risk classification. We evaluated whether pretreatment tumor apparent diffusion coefficient (ADC) derived from multiparametric MRI was associated with long‐term outcomes and provided additional prognostic ...
Cem Onal, Gurcan Erbay, Aysenur Elmali, Birhan Demirhan, Ozan Cem Guler   +4 more
wiley   +1 more source

Immunomodulatory Properties of Withania somnifera: Regulation of Innate Immune Cells and Clinical Implications

Phytotherapy Research, EarlyView.
ABSTRACT Withania somnifera (L.) Dunal (WS), commonly known as Ashwagandha, is a prominent medicinal herb in Ayurveda, with extensive therapeutic potential attributed to its diverse phytochemical profile. This review critically examines the immunomodulatory properties of WS, focusing on innate immune cell populations, including neutrophils, eosinophils,
Rana Yukta, Sonalika Gupta, Gagandeep Kaur, Partha Sarathi Mondal, Milirani Das, Anagha Ranade, Alok Kumar Srivastava, Sachin Kumar, Manoj Kumar Barthwal, Madhu Dikshit   +9 more
wiley   +1 more source

Catechins and Their Effect on the Gut Microbiome in Health and Cancer

Phytotherapy Research, EarlyView.
ABSTRACT Catechins are a group of flavonoids found primarily in green tea, fruits, and berries; they play a significant role in the modulation of the gut microbiota, thereby having an impact on gut health and cancer prevention. Owing to their low bioavailability, catechins are transformed by the gut microbiota into various bioactive metabolites such as
Prakash Monika, Bindu Sadanandan, Honnamachanahalli Ramachandraiah Tejashree, Maitreyi Darbha, Kirti Gupta, Srinivas Reneeka   +5 more
wiley   +1 more source