Results 91 to 100 of about 2,211,291 (297)

Differential expression of 5-alpha reductase isozymes in the prostate and its clinical implications

Asian Journal of Andrology, 2014
The development of human benign or malignant prostatic diseases is closely associated with androgens, primarily testosterone (T) and dihydrotestosterone (DHT). T is converted to DHT by 5-alpha reductase (5-AR) isozymes.
Kai Wang, Dong-Dong Fan, Song Jin, Nian-Zeng Xing, Yi-Nong Niu   +4 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

A hospital-based study of prostate biopsy results in Indian males

Journal of Family Medicine and Primary Care
Introduction: The prostate is a gland belonging to the male reproductive system. Aging results in the dysfunction of the prostate that may present as inflammation, enlargement, and cancer.
Mohd Khalid, M Mustafa Khan, Qader Ahmed Jalily, Dinesh Eshwar Mummareddi, Saritha Sirangi, Sri N S. Avinash Dande   +5 more
doaj   +1 more source

The research progress on multi-omics analysis biomarkers of benign prostatic hyperplasia [PDF]

Yixue xinzhi zazhi
Benign prostatic hyperplasia (BPH) is one of the most common benign diseases among the ageing male population with increasing prevalence, which can cause lower urinary tract symptoms and seriously affect the quality of life of patients.
QIAN Xinhang, GU Jiamin, LU Peiwen, YANG Shisong, FANG Cheng, LI Xiaodong, ZENG Xiantao   +6 more
doaj   +1 more source

Extending Service Beyond Active Duty: Generalizability of Rheumatoid Arthritis Research Conducted Among US Veterans

Arthritis Care &Research, EarlyView.
Biomedical research involving US veterans continues to advance health care beyond the Veterans Health Administration. This is particularly true in rheumatoid arthritis (RA), where veteran‐centric research has uncovered novel insights into pathogenesis, risk factors, and disease manifestations, informing clinical care and research across both veteran ...
Austin M. Wheeler, Joshua F. Baker, Jennifer L. Barton, Maria I. Danila, Tate M. Johnson, Kamini Kuchinad, Kaleb Michaud, Amir A. Razmjou, J. Steuart Richards, Namrata Singh, Isaac D. Smith, Katherine D. Wysham, Grant W. Cannon, Bryant R. England, Amy Joseph, Deana Lazaro, Katherine P. Liao, Courtney Loecker, Andreas Reimold, Beth I. Wallace, Ted R. Mikuls   +20 more
wiley   +1 more source

ORIGINAL ARTICLE p63 as a Complimentary Basal Cell Specific Marker to High Molecular Weight-Cytokeratin in Distinguishing Prostatic Carcinoma from Benign

, 2014
The diagnosis of prostatic carcinoma (Pca) on routine biopsies may be challenging, and to date the commonly used marker to distinguish prostate carcinoma from benign prostatic lesions has been High Molecular Weight-Cytokeratin (HMW-CK).
Prostatic Lesions
core  

3-Year results following treatment with the second generation of the temporary implantable nitinol device in men with LUTS secondary to benign prostatic obstruction

, 2020
Background: To report the 3-year results of a prospective, single arm, multicenter, international clinical study with the second generation of the temporary implantable nitinol device (iTIND; Medi-Tate Ltd®, Israel) on men suffering lower urinary tract ...
Schulman, Claude, Kadner, G., Kadner, Gregor, De Cillis, S., Porpiglia, Francesco, Fiori, C., Valerio, M., De Cillis, Sabrina, Amparore, Daniele, Valerio, Massimo, Porpiglia, F., Giannakis, Ioannis, Giannakis, I., Fiori, Cristian, Amparore, D., Schulman, C.   +15 more
core   +1 more source

The relationship between angiogenesis and cyclooxygenase-2 expression in prostate cancer [PDF]

, 2005
<b>OBJECTIVE</b>: To test the hypothesis that angiogenesis in prostate cancer is associated with tumour invasion and metastasis, and that this is mediated through increased cyclooxygenase-2 (COX-2) expression.
Mukherjee, R., Underwood, M.A., Edwards, J., Bartlett, J.M.S.   +3 more
core   +1 more source

Associations of Frailty With the Risk of Incident Cancer and Cancer‐Related Mortality in Veterans With Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective This study investigated the association between frailty and cancer incidence and mortality in patients with rheumatoid arthritis (RA). It aimed to identify how frailty influences cancer risk and cancer‐specific outcomes. Methods This retrospective cohort study analyzed data from the Veterans’ Affairs Rheumatoid Arthritis Registry (2002–2023).
Bhavik Bansal, Aaron Baraff, Katherine Wysham, James S. Andrews, Bryant R. England, Ted R. Mikuls, Joshua Baker, Kaleb Michaud, Alexa Meara, Una Makris, Carolyn Presley, Ariela Orkaby, Namrata Singh   +12 more
wiley   +1 more source