Results 71 to 80 of about 10,722,374 (289)

A Molecular Shielding Strategy to Develop Low Protein Binding, Renal Clearable Pan‐Cancer Near‐Infrared Probes

Advanced Functional Materials, EarlyView.
A molecular shielding strategy to convert “protein‐sticky” and “non‐tumor specific” clinical ICG dye, into a “low protein binding” and “tumor‐targeting” dye with prolonged blood circulation and renal clearance is described. These shielded ICGs demonstrate strong tumor accumulation and optimal tissue clearance, resulting in high tumor‐to‐background ...
Li Xiang, Kailin Mooney, Mingchong Dai, Morgan R. Stewart, Samantha Holland, Michael I. Henderson, Samuel Drennan, Ramon F. Barajas Jr., Jared M. Fischer, Adem Yildirim   +9 more
wiley   +1 more source

A hospital-based study of prostate biopsy results in Indian males

Journal of Family Medicine and Primary Care
Introduction: The prostate is a gland belonging to the male reproductive system. Aging results in the dysfunction of the prostate that may present as inflammation, enlargement, and cancer.
Mohd Khalid, M Mustafa Khan, Qader Ahmed Jalily, Dinesh Eshwar Mummareddi, Saritha Sirangi, Sri N S. Avinash Dande   +5 more
doaj   +1 more source

The research progress on multi-omics analysis biomarkers of benign prostatic hyperplasia [PDF]

Yixue xinzhi zazhi
Benign prostatic hyperplasia (BPH) is one of the most common benign diseases among the ageing male population with increasing prevalence, which can cause lower urinary tract symptoms and seriously affect the quality of life of patients.
QIAN Xinhang, GU Jiamin, LU Peiwen, YANG Shisong, FANG Cheng, LI Xiaodong, ZENG Xiantao   +6 more
doaj   +1 more source

A Fully Human Engineered Bone Niche With Endogenous Osteoclastogenesis Reveals Osteoclast‐Dependent Osteomimicry in Prostate Cancer Cells

Advanced Healthcare Materials, EarlyView.
A human 3D bone niche integrating osteoblasts and osteoclasts enables co‐culture with prostate cancer cell lines and patient‐derived organoids. The engineered niche (i) models aspects of reciprocal phenotypic regulation between osteoblasts and cancer cells, (ii) captures osteoclast‐enhanced osteomimicry in tumor cells, and (iii) establishes a ...
Andrea Mazzoleni, Robin Dolgos, Thomas Menter, Boris Dasen, Arnaud Scherberich, Clémentine Le Magnen, Manuele G. Muraro, Ivan Martin   +7 more
wiley   +1 more source

Affinity‐Tuned Albumin Hitchhiking Extends the Bioorthogonal Capture Window in Pretargeting Radiotheranostics

Advanced Healthcare Materials, EarlyView.
Pharmacokinetic engineering of clickable radioligands was achieved via albumin hitchhiking approach within a pretargeted radiotheranostics delivery platform. This approach reduced rapid renal elimination, expanded bioorthogonal capture window, boosted tumor uptake by ∼3.5‐fold, and improved the tumor‐to‐liver ratio by ∼6‐fold.
Xie He, Nicholas L. Fletcher, Gayathri R. Ediriweera, Yifei Zhu, James Humphries, Christopher B. Howard, Jiazheng Wang, Craig A. Bell, Kristian Kempe, Kristofer J. Thurecht   +9 more
wiley   +1 more source

Xanthogranulomatous prostatitis with benign prostatic hyperplasia: A rare combination

CHRISMED Journal of Health and Research, 2017
Xanthogranulomatous prostatitis is a rare benign granulomatous inflammation of the prostate. Only ten cases of such pathology have been reported in literature. Patients usually present with symptoms of lower urinary tract symptoms.
Navjot Grewal, Amit Tuli, Francis K Sridhar, Kim John Mammen   +3 more
doaj   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

End‐to‐End Sensing Systems for Breast Cancer: From Wearables for Early Detection to Lab‐Based Diagnosis Chips

Advanced Materials Technologies, EarlyView.
This review explores advances in wearable and lab‐on‐chip technologies for breast cancer detection. Covering tactile, thermal, ultrasound, microwave, electrical impedance tomography, electrochemical, microelectromechanical, and optical systems, it highlights innovations in flexible electronics, nanomaterials, and machine learning.
Neshika Wijewardhane, Lyn I. Jones, Richard M. Martin, Helen Winter, Faezeh Arab Hassani   +4 more
wiley   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Advances in the identification of novel cell signatures in benign prostatic hyperplasia and prostate cancer using single-cell RNA sequencing

Frontiers in Immunology
Nowadays, chronic benign and malignant prostatic diseases are prevalent, costly, and impose a significant burden. Benign prostatic hyperplasia (BPH), a common condition in the aging population, often coexists with localized prostate cancer (PCa).
Yu Pan, Qingqing Song, Bingjie Lai, He Ma   +3 more
doaj   +1 more source