Results 231 to 240 of about 87,504 (302)

A dose‐finding population pharmacokinetic/pharmacodynamic model of ginisortamab, an anti‐gremlin‐1 monoclonal antibody, in patients with solid tumours

British Journal of Clinical Pharmacology, EarlyView.
Aims Ginisortamab, a first‐in‐class human monoclonal antibody for the treatment of advanced solid tumours, binds to gremlin‐1 and restores bone morphogenetic protein signalling. We used pharmacokinetic/pharmacodynamic (PK/PD) modelling to characterize the relationship between ginisortamab dose and serum gremlin‐1 binding, using model‐based simulations ...
Yin Cheong Wong, Luisa Rojas Chavarro, Paul Jones, David Egging, Wanchana Ungphakorn, Marta Valle, Ivan Matthews   +6 more
wiley   +1 more source

Diagnostic value of plasma heat shock protein 90α and inflammatory markers in prostate cancer. [PDF]

Front Oncol
Zhang W, Miao Y, Liu L.
europepmc   +1 more source

The interplay between molecular architecture, pharmacology, and suspected adverse drug reactions associated with nonsteroidal androgen antagonists in the United Kingdom

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to correlate potential links between the suspected adverse drug reaction (ADR) profile of licensed nonsteroidal androgen receptor antagonists (NSARA) with their unique chemical properties and known off‐target polypharmacology. Methods Physicochemical and polypharmacology data were curated from the Electronic Medicines Compendium ...
Simrit Dhillon, Albert A. Antolin, Alan M. Jones   +2 more
wiley   +1 more source

Insights into the impact of neuropsychiatric disorders on prostate diseases: A 2-sample Mendelian randomization study. [PDF]

Medicine (Baltimore)
Xie H, Geng W.
europepmc   +1 more source

Exploring the potential mechanism of Huang'e capsule against spontaneous benign prostatic hyperplasia in beagle dogs using high-performance liquid chromatography-quadrupole-time-of-flight tandem mass spectrometry, gas chromatography-mass spectrometry, and network pharmacology. [PDF]

J Tradit Chin Med
Aicui MA, Qi P, Dingshi C, Zhonghui W, Chiyang Z, Junfang Z, Jianyan Y, Lei LI, Han Y, Shunheng Y, Jun G, Zuyue S.   +11 more
europepmc   +1 more source

Disease Progression and Outcomes in Patients With Benign Prostatic Hyperplasia: Protocol for a Multicenter Retrospective Cohort Study.

JMIR Res Protoc
Lv Z, Liu J, Lu Y, Zhang X, Gao F, Guo B, Zhang H, Li H, Lv C.   +8 more
europepmc   +1 more source

Evaluating the relationship between educational attainment, obesity-related indicators, and prostate diseases: A univariable and multivariable Mendelian randomization study. [PDF]

Medicine (Baltimore)
Ji WT, Wang YK, Jin XF, Wang SQ, Wang Y.
europepmc   +1 more source

Management of clinical failure after minimally invasive surgical therapies (MIST) for BPH: repeat MIST versus resection, enucleation or ablation-a narrative review from EAU endourology. [PDF]

World J Urol
Bogatova S, Morozov A, Gauhar V, Lifshitz D, Sukhanov R, Ehrlich Y, Asali M, Krupinov G, Golan S, Somani BK, Herrmann TRW, Enikeev D.   +11 more
europepmc   +1 more source

Mechanisms of prostatic inflammation-mediated male lower urinary tract symptoms. [PDF]

Am J Clin Exp Urol
Scharpf BR, Vezina CM.
europepmc   +1 more source