Results 201 to 210 of about 15,814 (254)
Some of the next articles are maybe not open access.
Ultrastructure of prostatic intraepithelial neoplasia
The Prostate, 1997Prostatic intraepithelial neoplasia (PIN) is the most likely precursor of prostatic adenocarcinoma. However, the ultrastructural features of PIN have not been defined in properly fixed tissues.In this study, we examined a total of 84 acini from 11 cases of high-grade PIN and matched benign epithelium and adenocarcinoma from patients undergoing radical ...
D G, Bostwick +2 more
openaire +2 more sources
Prostatic intraepithelial neoplasia and prostate-specific antigen
World Journal of Urology, 1993Prostatic intraepithelial neoplasia (PIN) is a putative premalignant lesion of the prostate gland. PIN has been demonstrated to share morphologic and phenotypic similarities to invasive carcinoma of the prostate. In addition, PIN is spatially related to invasive carcinoma and occurs with greater frequency in men whose prostates harbor carcinoma ...
J R, Porter, M K, Brawer
openaire +2 more sources
Follow-Up of Prostatic Intraepithelial Neoplasia
European Urology, 1996Biopsy or fine-needle aspiration cytology are the only appropriate methods for detection of prostatic intraepithelial neoplasia (PIN). PIN has been suggested to be a principal precursor of invasive carcinoma of the prostate. Most reports on an association of PIN and invasive prostatic cancer have a follow-up of less than 1 year, indicating that the ...
A, Berner, F J, Skjørten, S D, Fossà
openaire +2 more sources
Biomarker Expression in Prostatic Intraepithelial Neoplasia
European Urology, 1996This study was conducted to gain a better understanding of the underlying cellular events involved in the development of prostatic intraepithelial neoplasia (PIN) and to clarify the relationship of PIN to invasive prostatic adenocarcinoma (PCa).This article reviews previous studies from our laboratory and others of biomarker expression in PIN and PCa ...
R B, Myers, W E, Grizzle
openaire +2 more sources
Prostatic Intraepithelial Neoplasia
2009Two lesions have been regarded as putative prostatic cancer precursors-prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia (adenosis). PIN is confined within the epithelium without evidence of stromal invasion, although the basal cell layer may be discontinous and focally absent in high-grade PIN.
Guofeng Wang, Maode Lai, Guoping Ren
openaire +1 more source
Prostatic intraepithelial neoplasia: Animal models 2000
The Prostate, 2000Numerous animal models of preinvasive prostate cancer have been described in the past decade. Differences among models account for their variable applicability for answering specific research questions. The dog is the only known nonhuman spontaneous animal model of prostate cancer, but numerous transgenic and therapy-induced models have been generated ...
D G, Bostwick, D, Ramnani, J, Qian
openaire +2 more sources
Clinical Evolution of Prostatic Intraepithelial Neoplasia
European Urology, 1999High-grade prostatic intraepithelial neoplasia (PIN) is most likely a precursor of prostate cancer and is frequently associated with it whereas the direct link between low-grade PIN and cancer is not established. The clinical evolution of isolated high-grade PIN has been the object of much concern because of the possibility of undiagnosed prostate ...
Zlotta, Alexandre, Schulman, Claude
openaire +2 more sources
Prostatic Intraepithelial Neoplasia and Endocrine Manipulation
European Urology, 1999Prostatic intraepithelial neoplasia (PIN) is the most common precursor lesion of prostatic adenocarcinoma. In 50- to 70-year-old participants of a randomized screening program for prostate cancer (Rotterdam section of the ERSPC) the frequency of high-grade PIN as an isolated finding in sextant prostatic needle biopsies was estimated to be about 1%.
T H, van der Kwast, F, Labrie, B, Têtu
openaire +2 more sources
Cytological features of prostatic intraepithelial neoplasia
Diagnostic Cytopathology, 2006AbstractFine‐needle aspiration cytolotogy (FNAC) is an acknowledged method for diagnosing prostate cancer. False‐positive results are uncommon, but concerns have been raised that prostatic intraepithelial neoplasia (PIN) could be misinterpreted as carcinoma. Therefore, we attempted to describe cytological features of PIN.
Alexander, Valdman +3 more
openaire +2 more sources
Molecular biology of prostatic intraepithelial neoplasia
The Prostate, 1996High-grade PIN is the most likely precursor of prostatic adenocarcinoma, according to virtually all available evidence to date. The clinical importance of recognizing PIN is based on its strong association with prostatic carcinoma. PIN has a high predictive value as a marker for adenocarcinoma.
D G, Bostwick +2 more
openaire +2 more sources