Results 31 to 40 of about 57,355 (265)

Role of magnetic resonance imaging, magnetic resonance spectroscopy and transrectal ultrasound in evaluation of prostatic pathologies with focus on prostate cancer [PDF]

, 2017
Background: Prostate cancer (PC) is an important medical and socio-economical problem due to its increasing incidence. The development of the prostate specific antigen (PSA) test, and a continuing decrease in the rates of other common neoplasms, such as ...
Chandak, Nihar Umakant, Dhok, Avinash Parshuram, Lahoti, Amol Madanlal, Rantnaparkhi, Chetana Ramesh, Rawat, Jitesh Subhash, Tawari, Hitesh Sharad   +5 more
core   +1 more source

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source

Urinary cholesterol: its association with a macromolecular protein- lipid complex [PDF]

, 1984
The cholesterol-containing complexes in the urine of normal subjects and patients with diseases accompanied by hyperexcretion of urinary cholesterol were characterized. In normal subjects, the major portion of the recovered urinary cholesterol was eluted
Jüngst, Dieter, Karl, Hans Josef, Siess, E., Weiser, H.   +3 more
core  

Mapping of succinate dehydrogenase losses in 2258 epithelial neoplasms. [PDF]

, 2014
Losses in the succinate dehydrogenase (SDH) complex characterize 20% to 30% of extra-adrenal paragangliomas and 7% to 8% of gastric GISTs, and rare renal cell carcinomas.
Biernat, Wojciech, Czapiewski, Piotr, Langfort, Renata, Lasota, Jerzy, McCue, Peter, Miettinen, Markku, Sarlomo-Rikala, Maarit, Waloszczyk, Piotr, Wang, Zengfeng, Wazny, Krzysztof   +9 more
core   +1 more source

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

Cathepsin D expression levels in nongynecological solid tumors: Clinical and therapeutic implications [PDF]

, 2004
Cathepsin D is a lysosomal acid proteinase which is involved in the malignant progression of breast cancer and other gynecological tumors. Clinical investigations have shown that in breast cancer patients cathepsin D overexpression was significantly ...
Crescimanno, M., Flandina, C., Gebbia, N., Leto, G., Tumminello, F.   +4 more
core   +1 more source

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

Molecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

Frequency of primary solid malignant neoplasms in both sexes, as seen in our practice [PDF]

, 2007
Background: To determine the frequency of various histologic types of primary solid malignant neoplasms in males and females, in our practice, in a large series of surgical biopdies.
Ahmad, Zubair, Ahmed, Rashida, Ahsan, Aamir, Azad, Najamul Sahar, Hassan, Sheema H., Husain, Akhtar, Kayani, Naila, Khan, Ambreen Nasir, Pervez, Shahid, Yaqoob, Nausheen   +9 more
core   +1 more source

Transcriptional regulation of prostate kallikrein-like genes by androgen. [PDF]

, 1992
Using gene-specific synthetic oligonucleotides the expression and regulation of kallikrein-like genes in the human prostatic cancer cell line LNCaP were studied.
Fittler, Friedrich, Schulz, Peter, Wolf, Dieter A.   +2 more
core   +1 more source

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source